The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL

CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets

(2012) I. N. Shalova et al.   JOURNAL OF IMMUNOLOGY

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis

(2012) Shunxing Rong et al.   JOURNAL OF LIPID RESEARCH

Monocyte subpopulations and cardiovascular risk in chronic kidney disease

(2012) Gunnar H. Heine et al.   Nature Reviews Nephrology

Spleen Tyrosine Kinase Regulates AP-1 Dependent Transcriptional Response to Minimally Oxidized LDL

(2012) Soo-Ho Choi et al.   PLoS One

Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist

(2012) W. S. Bowen et al.   Science Signaling

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

(2012) Rongze Lu et al.   PLoS Pathogens

Protein tyrosine kinases in neutrophil activation and recruitment

(2011) Alexander Zarbock et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MyD88 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-Like Receptors 2 and 4

(2011) A. Phillip Owens et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Oral Spleen Tyrosine Kinase Inhibitor Fostamatinib Attenuates Inflammation and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice

(2011) Ingo Hilgendorf et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monocyte and Macrophage Dynamics During Atherogenesis

(2011) Klaus Ley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Rip2 Deficiency Leads to Increased Atherosclerosis Despite Decreased Inflammation

(2011) Malin C. Levin et al.   CIRCULATION RESEARCH

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes

(2011) T. Shibata et al.   INTERNATIONAL IMMUNOLOGY

Protein kinase Cδ is a critical component of Dectin-1 signaling in primary human monocytes

(2011) Deena H. Elsori et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Electrospray MS/MS reveals extensive and nonspecific oxidation of cholesterol esters in human peripheral vascular lesions

(2011) Patrick M. Hutchins et al.   JOURNAL OF LIPID RESEARCH

Different dimerisation mode for TLR4 upon endosomal acidification?

(2011) Monique Gangloff   TRENDS IN BIOCHEMICAL SCIENCES

Syk-coupled C-type lectins in immunity

(2011) Ann M. Kerrigan et al.   TRENDS IN IMMUNOLOGY

Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice

(2010) Mie Higashimori et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation

(2010) Fabienne Laugerette et al.   BIOCHIMIE

Toll-Like Receptor 4 Immunohistochemical Expression Is Enhanced in Macrophages of Symptomatic Carotid Atherosclerotic Plaques

(2010) Athanasios Katsargyris et al.   CEREBROVASCULAR DISEASES

Low Doses of Lipopolysaccharide and Minimally Oxidized Low-Density Lipoprotein Cooperatively Activate Macrophages via Nuclear Factor κB and Activator Protein-1

(2010) Philipp Wiesner et al.   CIRCULATION RESEARCH

Localisation and trafficking of Toll-like receptors: an important mode of regulation

(2010) Anne F McGettrick et al.   CURRENT OPINION IN IMMUNOLOGY

Oxidized Cholesteryl Esters and Phospholipids in Zebrafish Larvae Fed a High Cholesterol Diet

(2010) Longhou Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis

(2010) X. Wittebole et al.   MEDIATORS OF INFLAMMATION

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

Toll-Like Receptor-4 and Lipoprotein Accumulation in Macrophages

(2010) Yury I. Miller et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Src-family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross Talk

(2010) C. A. Lowell   Cold Spring Harbor Perspectives in Biology

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4–Dependent Fluid Phase Uptake

(2009) Soo-Ho Choi et al.   CIRCULATION RESEARCH

Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish

(2009) Konstantin Stoletov et al.   CIRCULATION RESEARCH

Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota

(2009) Patrice D Cani et al.   CURRENT OPINION IN PHARMACOLOGY

Dual 12/15- and 5-Lipoxygenase Deficiency in Macrophages Alters Arachidonic Acid Metabolism and Attenuates Peritonitis and Atherosclerosis in ApoE Knock-out Mice

(2009) Daniel Poeckel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Multi-Hit Inhibition of Circulating and Cell-Associated Components of the Toll-Like Receptor 4 Pathway by Oxidized Phospholipids

(2008) Elena von Schlieffen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice

(2008) K. R. Coenen et al.   DIABETOLOGIA

Cholesteryl Ester Hydroperoxides Are Biologically Active Components of Minimally Oxidized Low Density Lipoprotein

(2008) Richard Harkewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

The Roles of Pathogen-Associated Molecular Patterns in Atherosclerosis

(2008) Clett Erridge   TRENDS IN CARDIOVASCULAR MEDICINE