Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells

(2016) Christina Dillmann et al.   JOURNAL OF IMMUNOLOGY

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

(2016) Nathan Pankratz et al.   NATURE GENETICS

T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection

(2016) Alexandre P. Benechet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-17 in systemic lupus erythematosus: A comprehensive review

(2015) Duo Li et al.   AUTOIMMUNITY

S1PR4 is required for plasmacytoid dendritic cell differentiation

(2015) Christina Dillmann et al.   BIOLOGICAL CHEMISTRY

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils

(2015) Julia Barthelmes et al.   BRAIN BEHAVIOR AND IMMUNITY

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

(2015) Michael S. Donoviel et al.   FASEB JOURNAL

Comprehensive analysis ofsphingosine-1-phosphate receptormutants during zebrafish embryogenesis

(2015) Yu Hisano et al.   GENES TO CELLS

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

(2015) Victoria A. Blaho et al.   NATURE

Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies

(2015) Judy H Cho et al.   NATURE MEDICINE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Targeting the IL-17–TH17 pathway

(2015) Hilary S. Bartlett et al.   NATURE REVIEWS DRUG DISCOVERY

S1P-Dependent Trafficking of Intracellular Yersinia pestis through Lymph Nodes Establishes Buboes and Systemic Infection

(2014) Ashley L. St. John et al.   IMMUNITY

Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis

(2014) Heiko Sic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I Interferon in the Pathogenesis of Lupus

(2014) M. K. Crow   JOURNAL OF IMMUNOLOGY

Neutrophils Exhibit Differential Requirements for Homing Molecules in Their Lymphatic and Blood Trafficking into Draining Lymph Nodes

(2014) Carolina V. Gorlino et al.   JOURNAL OF IMMUNOLOGY

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

(2014) Kuzhuvelil B Harikumar et al.   NATURE IMMUNOLOGY

Type I Interferon in Human Autoimmunity

(2014) Timothy B. Niewold   Frontiers in Immunology

Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells

(2013) Yuan-Li Huang et al.   CELLULAR SIGNALLING

Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration

(2013) Benjamin Weichand et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

S1PR5 is pivotal for the homeostasis of patrolling monocytes

(2013) Emilie Debien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation

(2013) Francesca Cencetti et al.   FASEB JOURNAL

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

(2013) Christopher S Garris et al.   NATURE IMMUNOLOGY

S1P Regulation of Macrophage Functions in the Context of Cancer

(2012) Andreas Weigert et al.   Anti-Cancer Agents in Medicinal Chemistry

HIF-1  is a negative regulator of plasmacytoid DC development in vitro and in vivo

(2012) A. Weigert et al.   BLOOD

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Impaired IFN-  Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

(2012) V. Sisirak et al.   CANCER RESEARCH

Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

(2012) Divya Sekar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages

(2012) S Ley et al.   ONCOGENE

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists

(2011) Miguel Guerrero et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor

(2011) Mariangela Urbano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype

(2011) Mariangela Urbano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists

(2011) Miguel Guerrero et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sphingosine-1-phospate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model

(2011) Tobias Schulze et al.   FASEB JOURNAL

Rho GTPases and their role in organizing the actin cytoskeleton

(2011) S.-T. Sit et al.   JOURNAL OF CELL SCIENCE

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Deciphering the role of Th17 cells in human disease

(2011) Cailin Moira Wilke et al.   TRENDS IN IMMUNOLOGY

Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells

(2010) A. Weigert et al.   BLOOD

Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis

(2010) Petra Keul et al.   CIRCULATION RESEARCH

Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4

(2010) Sven Golfier et al.   FASEB JOURNAL

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

(2010) Jaclyn S. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

(2010) Kazuaki Takabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking

(2010) Maria L. Allende et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoskeletal mechanics of proplatelet maturation and platelet release

(2010) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Four-and-a-Half LIM Domain Protein 2 Is a Novel Regulator of Sphingosine 1-Phosphate Receptor 1 in CCL19-Induced Dendritic Cell Migration

(2010) K. Konig et al.   JOURNAL OF IMMUNOLOGY

The Origin and Maturity of Dendritic Cells Determine the Pattern of Sphingosine 1-Phosphate Receptors Expressed and Required for Efficient Migration

(2010) A. Rathinasamy et al.   JOURNAL OF IMMUNOLOGY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effect of S1P5 on proliferation and migration of human esophageal cancer cells

(2010) Wei-Min Hu   WORLD JOURNAL OF GASTROENTEROLOGY

Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon- 

(2009) Y. Gao et al.   BLOOD

Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P3 in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone

(2009) Barbara Nieuwenhuis et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

(2009) Chunlei Wu et al.   GENOME BIOLOGY

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE