期刊
MEDIATORS OF INFLAMMATION
卷 2017, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2017/6059203
关键词
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资金
- Deutsche Krebshilfe [70112451]
- Deutsche Forschungsgemeinschaft [SFB 1039, TP B04, TP B06]
- Else Kroner-Fresenius Foundation (EKFS)
- Research Training Groups Translational Research Innovation-Pharma (TRIP)
- Else Kroner-Fresenius-Graduate School (EKF-GK)
The sphingolipid sphingosine-1-phosphate (S1P) emerges as an important regulator of immunity, mainly by signaling through a family of five specific G protein-coupled receptors (S1PR1-5). While S1P signaling generally has the potential to affect not only trafficking but also differentiation, activation, and survival of a diverse range of immune cells, the specific outcome depends on the S1P receptor repertoire expressed on a given cell. Among the S1PRs, S1PR4 is specifically abundant in immune cells, suggesting a major role of the S1P/S1PR4 axis in immunity. Recent studies indeed highlight its role in activation of immune cells, differentiation, and, potentially, trafficking. In this review, we summarize the emerging data that support a major role of S1PR4 in modulating immunity in humans and mice and discuss therapeutic implications.
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