Proteases Revisited: Roles and Therapeutic Implications in Fibrosis

Indications for lung resection surgery and lung transplant in South American children with cystic fibrosis

(2018) Fabíola Villac Adde et al.   Paediatric Respiratory Reviews

Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis

(2017) C. Lin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pirfenidone and nintedanib for pulmonary fibrosis in clinical practice: Tolerability and adverse drug reactions

(2017) Jonathan A. Galli et al.   RESPIROLOGY

Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis

(2017) Chikara Komiya et al.   Scientific Reports

Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro

(2017) Thomas Stahnke et al.   PLoS One

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

(2016) Man J. Livingston et al.   Autophagy

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins

(2016) L. Wagner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Valproic acid attenuates renal fibrosis through the induction of autophagy

(2016) Koichiro Kawaoka et al.   Clinical and Experimental Nephrology

Artesunate modulates expression of matrix metalloproteinases and their inhibitors as well as collagen-IV to attenuate pulmonary fibrosis in rats

(2016) Y. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics

(2016) Michael Mak et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

The microenvironment controls invadosome plasticity

(2016) Julie Di Martino et al.   JOURNAL OF CELL SCIENCE

A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation

(2016) Shashi Chillappagari et al.   Journal of Cystic Fibrosis

Inhaled alpha 1 -proteinase inhibitor therapy in patients with cystic fibrosis

(2016) Amit Gaggar et al.   Journal of Cystic Fibrosis

Treatment of idiopathic pulmonary fibrosis: a position paper from a Nordic expert group

(2016) C. M. Sköld et al.   JOURNAL OF INTERNAL MEDICINE

DA-1229, a dipeptidyl peptidase IV inhibitor, protects against renal injury by preventing podocyte damage in an animal model of progressive renal injury

(2016) Jee Eun Lee et al.   LABORATORY INVESTIGATION

Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal–epithelial reversion induced by γ-secretase inhibition

(2016) Simona Dinicola et al.   LIFE SCIENCES

Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches

(2016) Emenike K. Onyido et al.   Molecular Cancer

The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access

(2016) Arun Kumar Somavarapu et al.   NEUROBIOLOGY OF DISEASE

Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF-κB Activation

(2016) Xue Li et al.   Oxidative Medicine and Cellular Longevity

The Role of Plasminogen Activator Inhibitor Type-1 in Fibrosis

(2016) Panagiotis Flevaris et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

DPPIV/CD26: a tumor suppressor or a marker of malignancy?

(2016) Aline Beckenkamp et al.   TUMOR BIOLOGY

Simultaneous knockdown of uPA and MMP9 can reduce breast cancer progression by increasing cell-cell adhesion and modulating EMT genes

(2016) Anuradha Moirangthem et al.   Scientific Reports

Autophagy and Reactive Oxygen Species Are Involved in Neutrophil Extracellular Traps Release Induced by C. albicans Morphotypes

(2016) Samyr Kenno et al.   Frontiers in Microbiology

Neutrophil Extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?

(2016) Bárbara Nery Porto et al.   Frontiers in Immunology

Inhibitors of Serine Proteases in Regulating the Production and Function of Neutrophil Extracellular Traps

(2016) Pawel Majewski et al.   Frontiers in Immunology

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease

(2016) Christopher Fox et al.   Scientific Reports

Structure of neprilysin in complex with the active metabolite of sacubitril

(2016) Nikolaus Schiering et al.   Scientific Reports

Role of the Urokinase-Fibrinolytic System in Epithelial–Mesenchymal Transition during Lung Injury

(2015) Amarnath Satheesh Marudamuthu et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis

(2015) Tzu-Min Hung et al.   AMERICAN JOURNAL OF PATHOLOGY

Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway

(2015) Qing-Qing Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cathepsin S: therapeutic, diagnostic, and prognostic potential

(2015) Richard D.A. Wilkinson et al.   BIOLOGICAL CHEMISTRY

Combined angiotensin receptor blockade and neprilysin inhibition attenuates angiotensin-II mediated renal cellular collagen synthesis

(2015) Bing H. Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR

(2015) P. U. Patil et al.   JOURNAL OF CELL SCIENCE

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

Soluble Neprilysin Is Predictive of Cardiovascular Death and Heart Failure Hospitalization in Heart Failure Patients

(2015) Antoni Bayés-Genís et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Involvement of urokinase in cigarette smoke extract-induced epithelial–mesenchymal transition in human small airway epithelial cells

(2015) Qin Wang et al.   LABORATORY INVESTIGATION

Treatment of hypertrophic scars and keloids by fractional carbon dioxide laser: a clinical, histological, and immunohistochemical study

(2015) O. A. Azzam et al.   LASERS IN MEDICAL SCIENCE

Leukocytes: The Double-Edged Sword in Fibrosis

(2015) Jakub Kryczka et al.   MEDIATORS OF INFLAMMATION

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

The invasive phenotype of placenta accreta extravillous trophoblasts associates with loss of E-cadherin

(2015) C.M. Duzyj et al.   PLACENTA

The innate immune system, toll-like receptors and dermal wound healing: A review

(2015) M.J. Portou et al.   VASCULAR PHARMACOLOGY

MicroRNA-31 functions as a tumor suppressor by regulating cell cycle and epithelial-mesenchymal transition regulatory proteins in liver cancer

(2015) Hyung Seok Kim et al.   Oncotarget

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Differential Expression and Enzymatic Activity of DPPIV/CD26 Affects Migration Ability of Cervical Carcinoma Cells

(2015) Aline Beckenkamp et al.   PLoS One

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

(2015) Yao-Song Gui et al.   PLoS One

miR-31 Dysregulation in Cystic Fibrosis Airways Contributes to Increased Pulmonary Cathepsin S Production

(2014) Sinéad Weldon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Elastase induces lung epithelial cell autophagy through placental growth factor

(2014) Hsin-Han Hou et al.   Autophagy

Production of soluble Neprilysin by endothelial cells

(2014) Sanjaya Kuruppu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

The roles of mesenchymal stem cells in tumor inflammatory microenvironment

(2014) Zhao Sun et al.   Journal of Hematology & Oncology

Suppression of InsP3 Receptor-Mediated Ca2+ Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis

(2014) D. Shilling et al.   JOURNAL OF NEUROSCIENCE

Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis

(2014) Li Zhang et al.   LABORATORY INVESTIGATION

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis

(2014) Giorgio Seano et al.   NATURE CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neprilysin inhibition in chronic kidney disease

(2014) P. Judge et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis

(2014) Angela Kill et al.   ARTHRITIS RESEARCH & THERAPY

Inhibitors of cathepsin G: a patent review (2005 to present)

(2013) Paulina Kosikowska et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties

(2013) Fabien Lecaille et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interstitial Collagen Catabolism

(2013) Gregg B. Fields   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells – Its relevance for CNP degradation

(2013) Arief Thong et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Crosstalk between Autophagy and Inflammasomes

(2013) Jae-Min Yuk et al.   MOLECULES AND CELLS

TGF-β2-Induced Invadosomes in Human Trabecular Meshwork Cells

(2013) Hong Han et al.   PLoS One

Effect of FK506 in reducing scar formation by inducing fibroblast apoptosis after sciatic nerve injury in rats

(2013) J Que et al.   Cell Death & Disease

Look people, “Atg” is an abbreviation for “autophagy-related.” That’s it.

(2012) Daniel J Klionsky   Autophagy

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Three-dimensional invasion of macrophages is mediated by cysteine cathepsins in protrusive podosomes

(2012) Zala Jevnikar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of EMT by TGFβ in cancer

(2012) Carl-Henrik Heldin et al.   FEBS LETTERS

IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner

(2012) Monika Maleszewska et al.   IMMUNOBIOLOGY

Matrix Metalloproteinase-2 Cleavage of the β1 Integrin Ectodomain Facilitates Colon Cancer Cell Motility

(2012) Jakub Kryczka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Cathepsin S Deficiency Results in Abnormal Accumulation of Autophagosomes in Macrophages and Enhances Ang II–Induced Cardiac Inflammation

(2012) Lili Pan et al.   PLoS One

Induction of epithelial–mesenchymal transition by transforming growth factor β

(2012) Aristidis Moustakas et al.   SEMINARS IN CANCER BIOLOGY

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cortactin Controls Cell Motility and Lamellipodial Dynamics by Regulating ECM Secretion

(2011) Bong Hwan Sung et al.   CURRENT BIOLOGY

Enzymatic preparation of 5-hydroxy-l-proline, N-Cbz-5-hydroxy-l-proline, and N-boc-5-hydroxy-l-proline from (α-N-protected)-l-ornithine using a transaminase or an amine oxidase

(2011) R.L. Hanson et al.   ENZYME AND MICROBIAL TECHNOLOGY

Serum DPPIV activity and CD26 expression on lymphocytes in patients with benign or malignant breast tumors

(2011) Aleksandra Erić-Nikolić et al.   IMMUNOBIOLOGY

Myofibroblastic differentiation in atypical fibroxanthomas occurring on sun-exposed skin and in a burn scar: an ultrastructural and immunohistochemical study

(2011) Ayako Ito et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase

(2011) Susana D. Lucas et al.   MEDICINAL RESEARCH REVIEWS

Diminished Prostaglandin E2Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

(2010) Toby M. Maher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CD10-bearing fibroblasts may inhibit skin inflammation by down-modulating substance P

(2010) Lining Xie et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny

(2010) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice

(2010) Asish K. Ghosh et al.   CIRCULATION

The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness

(2010) Zhiwei Wang et al.   CURRENT DRUG TARGETS

Structures of human proteinase 3 and neutrophil elastase - so similar yet so different

(2010) Eric Hajjar et al.   FEBS Journal

The origin of fibroblasts and mechanism of cardiac fibrosis

(2010) Guido Krenning et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

(2010) Yushan Zhu et al.   Protein & Cell

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Structure, function and antagonists of urokinase-type plasminogen activator

(2009) Maria Vincenza Carriero   Frontiers in Bioscience-Landmark

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

TGF -induced endothelial podosomes mediate basement membrane collagen degradation in arterial vessels

(2009) P. Rottiers et al.   JOURNAL OF CELL SCIENCE

Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions

(2009) C. Albiges-Rizo et al.   JOURNAL OF CELL SCIENCE

Trafficking and Cell Migration

(2009) Florian Ulrich et al.   TRAFFIC

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

Lysosomal Cathepsin B Participates in the Podosome-Mediated Extracellular Matrix Degradation and Invasion via Secreted Lysosomes in v-Src Fibroblasts

(2008) C. Tu et al.   CANCER RESEARCH

Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF- B/Snail1 pathway

(2008) R. Strippoli et al.   Disease Models & Mechanisms

Inhibition of airway proteases in cystic fibrosis lung disease

(2008) M. Griese et al.   EUROPEAN RESPIRATORY JOURNAL

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA