Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling

Mollisolactones A and B, novel dinormonoterpenes from the soft coral Sinularia mollis

(2016) Shi-Yie Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria

(2016) Christopher Weidner et al.   JOURNAL OF NATURAL PRODUCTS

Cytotoxic halogenated monoterpenes from Plocamium cartilagineum

(2016) Omar M. M. Sabry et al.   NATURAL PRODUCT RESEARCH

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway

(2015) Demetria Pavlou et al.   APOPTOSIS

Portrait of the PI3K/AKT pathway in colorectal cancer

(2015) Stine Aske Danielsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A Time to Kill: Targeting Apoptosis in Cancer

(2015) Jean Koff et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting cancer with sesterterpenoids: the new potential antitumor drugs

(2015) Caiguo Zhang et al.   Journal of Natural Medicines

Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities

(2014) Bo Hong et al.   CURRENT DRUG TARGETS

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Anticancer Effects of Different Seaweeds on Human Colon and Breast Cancers

(2014) Ghislain Moussavou et al.   Marine Drugs

Asperolide A, a Marine-Derived Tetranorditerpenoid, Induces G2/M Arrest in Human NCI-H460 Lung Carcinoma Cells, Is Mediated by p53-p21 Stabilization and Modulated by Ras/Raf/MEK/ERK Signaling Pathway

(2013) Cuiting Lv et al.   Marine Drugs

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway

(2013) C Lv et al.   Cell Death & Disease

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

(2013) P. Godwin et al.   Frontiers in Oncology

Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G0/G1cell cycle arrest and apoptosis

(2012) Winnie Lai Ting Kan et al.   INTERNATIONAL JOURNAL OF CANCER

Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro

(2012) Jo-Anne de la Mare et al.   INVESTIGATIONAL NEW DRUGS

Mass Spectrometry-Based Metabolomics to Elucidate Functions in Marine Organisms and Ecosystems

(2012) Sophie Goulitquer et al.   Marine Drugs

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives

(2012) Renato C. Pereira et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of tumor progression by naturally occurring terpenoids

(2011) Girija Kuttan et al.   PHARMACEUTICAL BIOLOGY

Identification and in vitro anti-esophageal cancer activity of a series of halogenated monoterpenes isolated from the South African seaweeds Plocamium suhrii and Plocamium cornutum

(2011) Edith M. Antunes et al.   PHYTOCHEMISTRY

Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells

(2010) Dinesh Thapa et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

(2010) Subash C. Gupta et al.   CANCER AND METASTASIS REVIEWS

Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy

(2010) Karin von Schwarzenberg et al.   CANCER LETTERS

Targeting NF-κB for colorectal cancer

(2010) Kei Sakamoto et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Constitutive NF- B Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth

(2009) K. Sakamoto et al.   CLINICAL CANCER RESEARCH

Mitochondrial cell death effectors

(2009) Dirk Brenner et al.   CURRENT OPINION IN CELL BIOLOGY

Marine natural products

(2009) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Terpenoids and breast cancer chemoprevention

(2008) Thangaiyan Rabi et al.   BREAST CANCER RESEARCH AND TREATMENT

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Apoptosis: A review of pro-apoptotic and anti-apoptotic pathways and dysregulation in disease

(2008) Mauria A. O'Brien et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE