Gene targeting, genome editing: from Dolly to editors

PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model

(2015) Jin He et al.   International Journal of Biological Sciences

Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9-Mediated Gene Targeting

(2015) Fengjiao Chen et al.   Journal of Genetics and Genomics

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

(2015) Benjamin P. Kleinstiver et al.   NATURE

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Law, history and lessons in the CRISPR patent conflict

(2015) Jacob S Sherkow   NATURE BIOTECHNOLOGY

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

A split-Cas9 architecture for inducible genome editing and transcription modulation

(2015) Bernd Zetsche et al.   NATURE BIOTECHNOLOGY

Small molecule–triggered Cas9 protein with improved genome-editing specificity

(2015) Kevin M Davis et al.   Nature Chemical Biology

Off-target mutations are rare in Cas9-modified mice

(2015) Vivek Iyer et al.   NATURE METHODS

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

(2015) Jeffrey C Miller et al.   NATURE METHODS

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

(2015) Daesik Kim et al.   NATURE METHODS

Artificial cloning of domestic animals

(2015) Carol L. Keefer   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design of a split-Cas9 enzyme complex

(2015) Addison V. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TALE nickase-mediatedSP110knockin endows cattle with increased resistance to tuberculosis

(2015) Haibo Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA

(2015) Yong Wang et al.   Scientific Reports

Efficient introgression of allelic variants by embryo-mediated editing of the bovine genome

(2015) Jingwei Wei et al.   Scientific Reports

Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk

(2015) Chenchen Cui et al.   Scientific Reports

The Nature of Embryonic Stem Cells

(2014) Graziano Martello et al.   Annual Review of Cell and Developmental Biology

Highly efficient targeted chromosome deletions using CRISPR/Cas9

(2014) Zuyong He et al.   BIOTECHNOLOGY AND BIOENGINEERING

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer

(2014) Xiaoqing Zhou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage

(2014) M.-E. Torres-Padilla et al.   DEVELOPMENT

Applications of Population Genetics to Animal Breeding, from Wright, Fisher and Lush to Genomic Prediction

(2014) William G. Hill   GENETICS

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

RAG1/2 Knockout Pigs with Severe Combined Immunodeficiency

(2014) J. Huang et al.   JOURNAL OF IMMUNOLOGY

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

(2014) Richard L Frock et al.   NATURE BIOTECHNOLOGY

Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons

(2014) Zoltán Ivics et al.   Nature Protocols

Efficient Generation of Myostatin (MSTN) Biallelic Mutations in Cattle Using Zinc Finger Nucleases

(2014) Junjie Luo et al.   PLoS One

Efficient Gene Knockout in Goats Using CRISPR/Cas9 System

(2014) Wei Ni et al.   PLoS One

Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency

(2014) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of mastitis resistance in cows by targeting human lysozyme gene to  -casein locus using zinc-finger nucleases

(2014) X. Liu et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer

(2014) Lei Bao et al.   Science China-Life Sciences

The new CRISPR–Cas system: RNA-guided genome engineering to efficiently produce any desired genetic alteration in animals

(2014) Davide Seruggia et al.   TRANSGENIC RESEARCH

Genome edited sheep and cattle

(2014) Chris Proudfoot et al.   TRANSGENIC RESEARCH

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

(2014) David K. C. Cooper et al.   XENOTRANSPLANTATION

Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs

(2014) Jing Yao et al.   Scientific Reports

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Pig genomics for biomedicine

(2013) Randall S Prather   NATURE BIOTECHNOLOGY

Rapid Cohort Generation and Analysis of Disease Spectrum of Large Animal Model of Cone Dystrophy

(2013) Corinne Kostic et al.   PLoS One

Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs

(2013) Jige Xin et al.   PLoS One

Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA

(2013) Masahito Watanabe et al.   PLoS One

Efficient nonmeiotic allele introgression in livestock using custom endonucleases

(2013) W. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Genetically engineered pig models for diabetes research

(2013) Eckhard Wolf et al.   TRANSGENIC RESEARCH

New Concepts of Immune Modulation in Xenotransplantation

(2013) Vikas Satyananda et al.   TRANSPLANTATION

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows

(2013) Xu Liu et al.   Nature Communications

Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs

(2013) Deug-Nam Kwon et al.   Scientific Reports

Live pigs produced from genome edited zygotes

(2013) Simon G. Lillico et al.   Scientific Reports

Applied Animal Genomics: Results from the Field

(2013) Alison L. Van Eenennaam et al.   Annual Review of Animal Biosciences

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases

(2012) Séverine Ménoret et al.   FASEB JOURNAL

Genomic Prediction in Animals and Plants: Simulation of Data, Validation, Reporting, and Benchmarking

(2012) H. D. Daetwyler et al.   GENETICS

Precision genome engineering with programmable DNA-nicking enzymes

(2012) E. Kim et al.   GENOME RESEARCH

Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases

(2012) Ping Li et al.   JOURNAL OF SURGICAL RESEARCH

Efficient TALEN-mediated gene knockout in livestock

(2012) D. F. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pluripotent cells in farm animals: state of the art and future perspectives

(2012) Monika Nowak-Imialek et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Induced Pluripotent Stem Cells from Pigs and Other Ungulate Species: An Alternative to Embryonic Stem Cells?

(2012) T Ezashi et al.   REPRODUCTION IN DOMESTIC ANIMALS

The state of the art for pluripotent stem cells derivation in domestic ungulates

(2012) Luis Fernando Malaver-Ortega et al.   THERIOGENOLOGY

Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning

(2011) Dongshan Yang et al.   CELL RESEARCH

Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle

(2011) Shengli Yu et al.   CELL RESEARCH

Leukemia Inhibitory Factor (LIF)-dependent, Pluripotent Stem Cells Established from Inner Cell Mass of Porcine Embryos

(2011) Bhanu Prakash V. L. Telugu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic salmon: a final leap to the grocery shelf?

(2011) Alison L Van Eenennaam et al.   NATURE BIOTECHNOLOGY

Advances in farm animal transgenesis

(2011) Wilfried A. Kues et al.   PREVENTIVE VETERINARY MEDICINE

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strategies for selection marker-free swine transgenesis using the Sleeping Beauty transposon system

(2011) Daniel F. Carlson et al.   TRANSGENIC RESEARCH

Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells

(2010) Toshihiro Kobayashi et al.   CELL

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Precision genetics for complex objectives in animal agriculture

(2010) S. C. Fahrenkrug et al.   JOURNAL OF ANIMAL SCIENCE

Transgenic pigs as models for translational biomedical research

(2010) Bernhard Aigner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Gene targeting with zinc finger nucleases to produce cloned eGFP knockout pigs

(2010) Jeffrey J. Whyte et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

(2010) Yannick Doyon et al.   NATURE METHODS

Pig transgenesis by Sleeping Beauty DNA transposition

(2010) Jannik E. Jakobsen et al.   TRANSGENIC RESEARCH

Capture of Authentic Embryonic Stem Cells from Rat Blastocysts

(2008) Mia Buehr et al.   CELL

Animal pharming, two decades on

(2008) Alexander Kind et al.   TRANSGENIC RESEARCH