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Title
Engineering large animal models of human disease
Authors
Keywords
-
Journal
JOURNAL OF PATHOLOGY
Volume 238, Issue 2, Pages 247-256
Publisher
Wiley
Online
2015-09-28
DOI
10.1002/path.4648
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- (2015) Heidi Ledford NATURE
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- (2014) Davide Seruggia et al. TRANSGENIC RESEARCH
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- (2014) Chris Proudfoot et al. TRANSGENIC RESEARCH
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- In vivo genome editing using a high-efficiency TALEN system
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- Efficient TALEN-mediated gene knockout in livestock
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- Double-Strand Break End Resection and Repair Pathway Choice
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- Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung
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- (2011) Jeffrey J. Whyte et al. MOLECULAR REPRODUCTION AND DEVELOPMENT
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- Transgenic pigs as models for translational biomedical research
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