Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches

Quantitation of Site-Specific Glycosylation in Manufactured Recombinant Monoclonal Antibody Drugs

(2016) Nan Yang et al.   ANALYTICAL CHEMISTRY

Optimal Synthetic Glycosylation of a Therapeutic Antibody

(2016) Thomas B. Parsons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Parallel development of chromatographic and mass-spectrometric methods for quantitative analysis of glycation on an IgG1 monoclonal antibody

(2016) Kornél Viski et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Simultaneous monitoring of oxidation, deamidation, isomerization, and glycosylation of monoclonal antibodies by liquid chromatography-mass spectrometry method with ultrafast tryptic digestion

(2016) Yi Wang et al.   mAbs

N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies

(2016) Sha Sha et al.   TRENDS IN BIOTECHNOLOGY

Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

(2016) Yang Yang et al.   Nature Communications

Integrated Microfluidic Capillary Electrophoresis-Electrospray Ionization Devices with Online MS Detection for the Separation and Characterization of Intact Monoclonal Antibody Variants

(2015) Erin A. Redman et al.   ANALYTICAL CHEMISTRY

A Method for In-Depth Structural Annotation of Human Serum Glycans That Yields Biological Variations

(2015) Ting Song et al.   ANALYTICAL CHEMISTRY

A chemical and computational approach to comprehensive glycation characterization on antibodies

(2015) Ramsey A Saleem et al.   mAbs

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

(2015) Ewald TJ van den Bremer et al.   mAbs

In-Depth Method for the Characterization of Glycosylation in Manufactured Recombinant Monoclonal Antibody Drugs

(2014) Ting Song et al.   ANALYTICAL CHEMISTRY

Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality

(2014) Kurt Brorson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry

(2014) Sara Rosati et al.   Nature Protocols

Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies

(2013) Hao Zhang et al.   FEBS LETTERS

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

(2013) Rebecca J. Rose et al.   mAbs

Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques

(2013) Daniel Ayoub et al.   mAbs

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

(2013) Sara Rosati et al.   mAbs

Glycoproteomic Analysis of Antibodies

(2013) Gerhild Zauner et al.   MOLECULAR & CELLULAR PROTEOMICS

Characterization of Therapeutic Antibodies and Related Products

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

The impact of glycosylation on monoclonal antibody conformation and stability

(2012) Kai Zheng et al.   mAbs

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

(2012) Steven A. Berkowitz et al.   NATURE REVIEWS DRUG DISCOVERY

Isolation and characterization of IgG1 with asymmetrical Fc glycosylation

(2011) S. Ha et al.   GLYCOBIOLOGY

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

The effect of sucrose hydrolysis on the stability of protein therapeutics during accelerated formulation studies

(2009) Douglas D. Banks et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-orbitrap mass spectrometer

(2009) Pavel V. Bondarenko et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

IgG glycosylation analysis

(2009) Carolin Huhn et al.   PROTEOMICS

C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes

(2008) Lawrence W. Dick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS