Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

Microfluidic platform with spatiotemporally controlled micro-environment for studying long-term C. elegans developmental arrests

(2017) Weipeng Zhuo et al.   LAB ON A CHIP

High-throughput screening in the C. elegans nervous system

(2017) Holly E. Kinser et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Scalable electrophysiology in intact small animals with nanoscale suspended electrode arrays

(2017) Daniel L. Gonzales et al.   Nature Nanotechnology

C. elegans-on-a-chip for in situ and in vivo Ag nanoparticles’ uptake and toxicity assay

(2017) Jin Ho Kim et al.   Scientific Reports

The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease

(2017) Francesca Farina et al.   Scientific Reports

An automated microfluidic system for screening Caenorhabditis elegans behaviors using electrotaxis

(2016) Dingsheng Liu et al.   Biomicrofluidics

Continuous-flow C. elegans fluorescence expression analysis with real-time image processing through microfluidics

(2016) Yuanjun Yan et al.   BIOSENSORS & BIOELECTRONICS

Microfluidics in systems biology — hype or truly useful?

(2016) Yi Liu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Drug Discovery in Fish, Flies, and Worms

(2016) Kevin Strange   ILAR JOURNAL

Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice

(2016) Guoli Zhu et al.   Integrative Biology

Versatile size-dependent sorting of C. elegans nematodes and embryos using a tunable microfluidic filter structure

(2016) Li Dong et al.   LAB ON A CHIP

Soil-on-a-Chip: microfluidic platforms for environmental organismal studies

(2016) Claire E. Stanley et al.   LAB ON A CHIP

On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites

(2016) Li Dong et al.   LAB ON A CHIP

C. elegans screening strategies to identify pro-longevity interventions

(2016) Silvia Maglioni et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

(2016) Matteo Cornaglia et al.   Molecular Neurodegeneration

Microfluidic Devices in Advanced Caenorhabditis elegans Research

(2016) Muniesh Muthaiyan Shanmugam et al.   MOLECULES

High-Content Screening for Quantitative Cell Biology

(2016) Mojca Mattiazzi Usaj et al.   TRENDS IN CELL BIOLOGY

Long-term time-lapse microscopy of C. elegans post-embryonic development

(2016) Nicola Gritti et al.   Nature Communications

Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

(2016) Sudip Mondal et al.   Nature Communications

Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity

(2016) Mark D. Mathew et al.   PLoS Neglected Tropical Diseases

Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research

(2016) Janis C. Weeks et al.   International Journal for Parasitology-Drugs and Drug Resistance

Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans

(2016) Bhagwati Gupta et al.   Micromachines

Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans

(2016) Hyundoo Hwang et al.   Scientific Reports

Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans

(2016) Han-Sheng Chuang et al.   Scientific Reports

HandKAchip - Hands-free killing assay on a chip

(2016) Kyung Suk Lee et al.   Scientific Reports

Quantitative analysis of Caenorhabditis elegans chemotaxis using a microfluidic device

(2015) Liang Hu et al.   ANALYTICA CHIMICA ACTA

A nanoliter self-priming compartmentalization chip for point-of-care digital PCR analysis

(2015) Qi Song et al.   BIOMEDICAL MICRODEVICES

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

(2015) Xi Chen et al.   Chemistry Central Journal

The promises of neurodegenerative disease modeling

(2015) Jean-Antoine Lepesant   COMPTES RENDUS BIOLOGIES

Highly efficient microfluidic sorting device for synchronizing developmental stages of C. elegans based on deflecting electrotaxis

(2015) Xixian Wang et al.   LAB ON A CHIP

High-throughput, motility-based sorter for microswimmers such as C. elegans

(2015) Jinzhou Yuan et al.   LAB ON A CHIP

A droplet microchip with substance exchange capability for the developmental study of C. elegans

(2015) Hui Wen et al.   LAB ON A CHIP

Hydrogel-droplet microfluidic platform for high-resolution imaging and sorting of early larval Caenorhabditis elegans

(2015) Guillaume Aubry et al.   LAB ON A CHIP

A microfluidic device and automatic counting system for the study of C. elegans reproductive aging

(2015) Siran Li et al.   LAB ON A CHIP

A size threshold governsCaenorhabditis elegansdevelopmental progression

(2015) Sravanti Uppaluri et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Microfluidic device for analysis of gas-evoked neuronal sensing in C. elegans

(2015) Liang Hu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Caenorhabditis elegans is a useful model for anthelmintic discovery

(2015) Andrew R. Burns et al.   Nature Communications

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

(2015) Matteo Cornaglia et al.   Scientific Reports

A gene-expression-based neural code for food abundance that modulates lifespan

(2015) Eugeni V Entchev et al.   eLife

Micro-/nanofluidic device for tunable generation of a concentration gradient: application to Caenorhabditis elegans chemotaxis

(2014) Zhongwei Wang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A perspective on optical developments in microfluidic platforms forCaenorhabditis elegansresearch

(2014) Guillaume Aubry et al.   Biomicrofluidics

Microfluidic platform integrated with worm-counting setup for assessing manganese toxicity

(2014) Beibei Zhang et al.   Biomicrofluidics

A multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features in C. elegans

(2014) Hyewon Lee et al.   LAB ON A CHIP

A high-throughput device for size based separation of C. elegans developmental stages

(2014) Xiaoni Ai et al.   LAB ON A CHIP

A continuous-flow C. elegans sorting system with integrated optical fiber detection and laminar flow switching

(2014) Yuanjun Yan et al.   LAB ON A CHIP

StyletChip: a microfluidic device for recording host invasion behaviour and feeding of plant parasitic nematodes

(2014) Chunxiao Hu et al.   LAB ON A CHIP

A Fully Automated Microfluidic Femtosecond Laser Axotomy Platform for Nerve Regeneration Studies in C. elegans

(2014) Sertan Kutal Gokce et al.   PLoS One

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

(2014) Pénélope A. Andreux et al.   Scientific Reports

C. elegans in high-throughput drug discovery

(2013) Linda P. O'Reilly et al.   ADVANCED DRUG DELIVERY REVIEWS

WormFarm: a quantitative control and measurement device toward automatedCaenorhabditis elegansaging analysis

(2013) Bo Xian et al.   AGING CELL

Exploring Living Multicellular Organisms, Organs, and Tissues Using Microfluidic Systems

(2013) Venkataragavalu Sivagnanam et al.   CHEMICAL REVIEWS

Animal microsurgery using microfluidics

(2013) Jeffrey N Stirman et al.   CURRENT OPINION IN BIOTECHNOLOGY

Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip

(2013) Hui Wen et al.   Integrative Biology

A microfluidic device for the continuous culture and analysis ofCaenorhabditis elegansin a toxic aqueous environment

(2013) Jaehoon Jung et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

An integrated microfluidic platform for evaluating in vivo antimicrobial activity of natural compounds using a whole-animal infection model

(2013) Jianping Yang et al.   LAB ON A CHIP

C.L.I.P.–continuous live imaging platform for direct observation of C. elegans physiological processes

(2013) Jan Krajniak et al.   LAB ON A CHIP

Durable spatiotemporal surveillance of Caenorhabditis elegans response to environmental cues

(2013) Ronen B. Kopito et al.   LAB ON A CHIP

New tools and new biology: Recent miniaturized systems for molecular and cellular biology

(2013) Morgan Hamon et al.   MOLECULES AND CELLS

Drug Absorption Efficiency in Caenorhbditis elegans Delivered by Different Methods

(2013) Shan-Qing Zheng et al.   PLoS One

An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans

(2013) Chi K. Leung et al.   PLoS One

NeuroChip: A Microfluidic Electrophysiological Device for Genetic and Chemical Biology Screening of Caenorhabditis elegans Adult and Larvae

(2013) Chunxiao Hu et al.   PLoS One

Microfabricated Polyacrylamide Devices for the Controlled Culture of Growing Cells and Developing Organisms

(2013) Philippe Nghe et al.   PLoS One

Reduced Sleep-Like Quiescence in Both Hyperactive and Hypoactive Mutants of the Galphaq Gene egl-30 during lethargus in Caenorhabditis elegans

(2013) Juliane Schwarz et al.   PLoS One

An Automated Microfluidic Multiplexer for Fast Delivery of C. elegans Populations from Multiwells

(2013) Navid Ghorashian et al.   PLoS One

Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease

(2013) Kamran Honarnejad et al.   PLoS One

High-throughput imaging of neuronal activity in Caenorhabditis elegans

(2013) J. Larsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of an integrated microfluidic device for evaluating of in vivo chemo-sensing of intact Caenorhabditis elegans

(2013) Jingjing Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Caenorhabditis-in-Drop Array for Monitoring C. elegans Quiescent Behavior

(2013) Samuel J. Belfer et al.   SLEEP

Microfluidic laboratories for C. elegans enhance fundamental studies in biology

(2013) Natalia A. Bakhtina et al.   RSC Advances

Multiparameter evaluation of the longevity in C. elegans under stress using an integrated microfluidic device

(2012) Hui Wen et al.   BIOMEDICAL MICRODEVICES

A microfluidic device for rapid screening of chemotaxis-defective Caenorhabditis elegans mutants

(2012) Jianping Yang et al.   BIOMEDICAL MICRODEVICES

Quantitative screening of genes regulating tryptophan hydroxylase transcription in Caenorhabditis elegans using microfluidics and an adaptive algorithm

(2012) Hyewon Lee et al.   Integrative Biology

Electrical sorting of Caenorhabditis elegans

(2012) Pouya Rezai et al.   LAB ON A CHIP

A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans

(2012) Shawn R. Lockery et al.   LAB ON A CHIP

A sorting strategy for C. elegans based on size-dependent motility and electrotaxis in a micro-structured channel

(2012) Bicheng Han et al.   LAB ON A CHIP

Autonomous screening of C. elegans identifies genes implicated in synaptogenesis

(2012) Matthew M Crane et al.   NATURE METHODS

Laterally Orienting C. elegans Using Geometry at Microscale for High-Throughput Visual Screens in Neurodegeneration and Neuronal Development Studies

(2012) Ivan de Carlos Cáceres et al.   PLoS One

Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms

(2011) Donald Wlodkowic et al.   CYTOMETRY PART A

Agarose hydrogel microcompartments for imaging sleep- and wake-like behavior and nervous system development in Caenorhabditis elegans larvae

(2011) Henrik Bringmann   JOURNAL OF NEUROSCIENCE METHODS

High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments

(2011) Dirk R Albrecht et al.   NATURE METHODS

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

High-throughput study of synaptic transmission at the neuromuscular junction enabled by optogenetics and microfluidics

(2010) Jeffrey N. Stirman et al.   JOURNAL OF NEUROSCIENCE METHODS

Microfluidics-enabled phenotyping, imaging, and screening of multicellular organisms

(2010) Matthew M. Crane et al.   LAB ON A CHIP

Design and Implementation of High Throughput Screening Assays

(2010) Ricardo Macarrón et al.   MOLECULAR BIOTECHNOLOGY

Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans

(2009) S. Elizabeth Hulme et al.   LAB ON A CHIP

Worm chips: Microtools for C. elegans biology

(2009) Nikos Chronis   LAB ON A CHIP

The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis

(2008) Frederick A. Partridge et al.   DEVELOPMENTAL BIOLOGY

Artificial Dirt: Microfluidic Substrates for Nematode Neurobiology and Behavior

(2008) S. R. Lockery et al.   JOURNAL OF NEUROPHYSIOLOGY

Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans

(2008) Kwanghun Chung et al.   NATURE METHODS