Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

Hydrogel-droplet microfluidic platform for high-resolution imaging and sorting of early larval Caenorhabditis elegans

(2015) Guillaume Aubry et al.   LAB ON A CHIP

Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases

(2014) C. I. Nussbaum-Krammer et al.   Disease Models & Mechanisms

On-demand optical immobilization of Caenorhabditis elegans for high-resolution imaging and microinjection

(2014) Hyundoo Hwang et al.   LAB ON A CHIP

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Amyloid-beta (Aβ1–42)-induced paralysis in Caenorhabditis elegans is reduced by restricted cholesterol supply

(2014) Charlotte Regitz et al.   NEUROSCIENCE LETTERS

Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes

(2014) A. J. Pratt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Exploring Living Multicellular Organisms, Organs, and Tissues Using Microfluidic Systems

(2013) Venkataragavalu Sivagnanam et al.   CHEMICAL REVIEWS

Modeling neurodegenerative diseases in Caenorhabditis elegans

(2013) Jia Li et al.   EXPERIMENTAL NEUROLOGY

Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

(2013) Anja Kunze et al.   Integrative Biology

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

(2013) V. Jovaisaite et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

C.L.I.P.–continuous live imaging platform for direct observation of C. elegans physiological processes

(2013) Jan Krajniak et al.   LAB ON A CHIP

ALS and neuromuscular disease: in search of the Holy Grail

(2013) Matthew C Kiernan   LANCET NEUROLOGY

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Microfluidic laboratories for C. elegans enhance fundamental studies in biology

(2013) Natalia A. Bakhtina et al.   RSC Advances

A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans

(2012) Shawn R. Lockery et al.   LAB ON A CHIP

Laterally Orienting C. elegans Using Geometry at Microscale for High-Throughput Visual Screens in Neurodegeneration and Neuronal Development Studies

(2012) Ivan de Carlos Cáceres et al.   PLoS One

Chemistry and the Worm: Caenorhabditis elegans as a Platform for Integrating Chemical and Biological Research

(2011) S. Elizabeth Hulme et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Microfluidic chamber arrays for whole-organism behavior-based chemical screening

(2011) Kwanghun Chung et al.   LAB ON A CHIP

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Undulatory Swimming in Viscoelastic Fluids

(2011) X. N. Shen et al.   PHYSICAL REVIEW LETTERS

ALS genetic modifiers that increase survival of SOD1 mice and are suitable for therapeutic development

(2011) Giulietta Riboldi et al.   PROGRESS IN NEUROBIOLOGY

Subcellular in vivo time-lapse imaging and optical manipulation of Caenorhabditis elegans in standard multiwell plates

(2011) Christopher B. Rohde et al.   Nature Communications

Long-term high-resolution imaging and culture of C. elegans in chip-gel hybrid microfluidic device for developmental studies

(2010) Jan Krajniak et al.   LAB ON A CHIP

Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration

(2010) C. Samara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A programmable microvalve-based microfluidic array for characterization of neurotoxin-induced responses of individual C. elegans

(2009) Hui Ma et al.   Biomicrofluidics

Worm chips: Microtools for C. elegans biology

(2009) Nikos Chronis   LAB ON A CHIP

Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases

(2009) Manuel Zimmer et al.   NEURON

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

(2009) Tali Gidalevitz et al.   PLoS Genetics

Femtosecond laser nanoaxotomy lab-on-a-chip for in vivo nerve regeneration studies

(2008) Samuel X Guo et al.   NATURE METHODS

Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans

(2008) Kwanghun Chung et al.   NATURE METHODS

The Parallel Worm Tracker: A Platform for Measuring Average Speed and Drug-Induced Paralysis in Nematodes

(2008) Daniel Ramot et al.   PLoS One

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics

Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Implications

(2007) Mauro Cozzolino et al.   ANTIOXIDANTS & REDOX SIGNALING