An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans

Cell-based high-throughput screens for the discovery of chemotherapeutic agents

(2015) Jennifer T Fox et al.   Oncotarget

Caenorhabditis elegans-based Model Systems for Antifungal Drug Discovery

(2012) Cleo G. Anastassopoulou et al.   CURRENT PHARMACEUTICAL DESIGN

Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance

(2012) Keith P. Choe et al.   DRUG METABOLISM REVIEWS

Worms take to the slo lane: a perspective on the mode of action of emodepside

(2012) Lindy Holden-Dye et al.   INVERTEBRATE NEUROSCIENCE

Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer

(2011) Xiangdong Ma et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1

(2011) Chi K. Leung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evaluation of Pharmacokinetic, Biodistribution, Pharmacodynamic, and Toxicity Profile of Free Juglone and Its Sterically Stabilized Liposomes

(2011) B. Kiran Aithal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

WormBase 2012: more genomes, more data, new website

(2011) K. Yook et al.   NUCLEIC ACIDS RESEARCH

Two Faces of Protein Kinase Cδ: The Contrasting Roles of PKCδ in Cell Survival and Cell Death

(2011) Alakananda Basu et al.   TheScientificWorldJOURNAL

Caenorhabditis elegans as a model to screen plant extracts and compounds as natural anthelmintics for veterinary use

(2011) Luciana M. Katiki et al.   VETERINARY PARASITOLOGY

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

(2011) Gregory M. Solis et al.   Jove-Journal of Visualized Experiments

Small Molecule Probes of Cellular Pathways and Networks

(2010) Adam B. Castoreno et al.   ACS Chemical Biology

The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel

(2010) Qian Liu et al.   BMC Medical Genomics

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

PKC and the control of localized signal dynamics

(2010) Carine Rosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic and Cellular Characterization of Caenorhabditis elegans Mutants Abnormal in the Regulation of Many Phase II Enzymes

(2010) Koichi Hasegawa et al.   PLoS One

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

A Novel High Throughput Assay for Anthelmintic Drug Screening and Resistance Diagnosis by Real-Time Monitoring of Parasite Motility

(2010) Michael J. Smout et al.   PLoS Neglected Tropical Diseases

Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1

(2009) Sang-Kyu Park et al.   AGING CELL

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Cdc25B Dual-Specificity Phosphatase Inhibitors Identified in a High-Throughput Screen of the NIH Compound Library

(2009) Paul A. Johnston et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters

(2009) Paul Gleeson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells

(2009) B. Kiran Aithal et al.   CELL BIOLOGY INTERNATIONAL

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

(2009) Jens-Uwe Peters et al.   ChemMedChem

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Novel trends in high-throughput screening

(2009) Lorenz M Mayr et al.   CURRENT OPINION IN PHARMACOLOGY

Neglected Diseases Amid Wealth In The United States And Europe

(2009) Peter Hotez   HEALTH AFFAIRS

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

(2009) Aaron J. Przybysz et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

(2009) K. P. Choe et al.   MOLECULAR AND CELLULAR BIOLOGY

Exploratory drug safety: A discovery strategy to reduce attrition in development

(2009) Alan S. Bass et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

(2009) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis

(2008) Frederick A. Partridge et al.   DEVELOPMENTAL BIOLOGY

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

(2008) Ahmed A Sayed et al.   NATURE MEDICINE

Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin

(2008) Christian Oresajo et al.   Journal of Cosmetic Dermatology

The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan

(2008) James J. Collins et al.   PLoS Genetics

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response inCaenorhabditis elegans

(2007) Nate W. Kahn et al.   BIOCHEMICAL JOURNAL