New tools and new biology: Recent miniaturized systems for molecular and cellular biology

Cell-Based Dose Responses from Open-Well Microchambers

(2013) Morgan Hamon et al.   ANALYTICAL CHEMISTRY

A novel microfluidic co-culture system for investigation of bacterial cancer targeting

(2013) Jung Woo Hong et al.   LAB ON A CHIP

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

(2013) Andries D. van der Meer et al.   LAB ON A CHIP

The Influence of Electric Field and Confinement on Cell Motility

(2013) Yu-Ja Huang et al.   PLoS One

Next-generation sequencing: The future of molecular genetics in poultry production and food safety

(2013) S. Diaz-Sanchez et al.   POULTRY SCIENCE

Single-molecule emulsion PCR in microfluidic droplets

(2012) Zhi Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Strategy for Signaling Molecule Detection by Using an Integrated Microfluidic Device Coupled with Mass Spectrometry to Study Cell-to-Cell Communication

(2012) Sifeng Mao et al.   ANALYTICAL CHEMISTRY

A microfluidic-based electrochemical biochip for label-free diffusion-restricted DNA hybridization analysis

(2012) Hadar Ben-Yoav et al.   BIOSENSORS & BIOELECTRONICS

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Isothermal nucleic acid amplification technologies for point-of-care diagnostics: a critical review

(2012) Pascal Craw et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Microfluidic: An innovative tool for efficient cell sorting

(2012) Julien Autebert et al.   METHODS

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Microfluidic Chips for In Vivo Imaging of Cellular Responses to Neural Injury in Drosophila Larvae

(2012) Mostafa Ghannad-Rezaie et al.   PLoS One

Increased Asymmetric and Multi-Daughter Cell Division in Mechanically Confined Microenvironments

(2012) Henry Tat Kwong Tse et al.   PLoS One

Miniaturized Embryo Array for Automated Trapping, Immobilization and Microperfusion of Zebrafish Embryos

(2012) Jin Akagi et al.   PLoS One

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

Molecular Detection and Genotyping of Noroviruses

(2012) Ambroos Stals et al.   Food and Environmental Virology

Creation of Stepwise Concentration Gradient in Picoliter Droplets for Parallel Reactions of Matrix Metalloproteinase II and IX

(2011) Sachin Jambovane et al.   ANALYTICAL CHEMISTRY

Log-Scale Dose Response of Inhibitors on a Chip

(2011) Jae Young Yun et al.   ANALYTICAL CHEMISTRY

Designed Biointerface Using Near-Infrared Quantum Dots for Ultrasensitive Surface Plasmon Resonance Imaging Biosensors

(2011) Lidija Malic et al.   ANALYTICAL CHEMISTRY

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

(2011) Benjamin J. Hindson et al.   ANALYTICAL CHEMISTRY

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics

(2011) Fan Yang et al.   Biomicrofluidics

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms

(2011) Donald Wlodkowic et al.   CYTOMETRY PART A

Trapping and imaging of micron-sized embryos using dielectrophoresis

(2011) Khashayar Khoshmanesh et al.   ELECTROPHORESIS

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Miniaturized isothermal nucleic acid amplification, a review

(2011) Peter J. Asiello et al.   LAB ON A CHIP

Zebrafish embryo development in a microfluidic flow-through system

(2011) Eric M. Wielhouwer et al.   LAB ON A CHIP

Fish and Chips: a microfluidic perfusion platform for monitoring zebrafish development

(2011) Deepak Choudhury et al.   LAB ON A CHIP

A living system on a chip

(2011) Monya Baker   NATURE

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

(2011) Masha Prager-Khoutorsky et al.   NATURE CELL BIOLOGY

High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays

(2011) Véronique Lecault et al.   NATURE METHODS

Single-cell genomics

(2011) Tomer Kalisky et al.   NATURE METHODS

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A PDMS microfluidic impedance immunosensor for E. coli O157:H7 and Staphylococcus aureus detection via antibody-immobilized nanoporous membrane

(2011) Fei Tan et al.   SENSORS AND ACTUATORS B-CHEMICAL

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Characterization and evaluation of two-dimensional microfluidic chip-HPLC coupled to tandem mass spectrometry for quantitative analysis of 7-aminoflunitrazepam in human urine

(2010) Hsin-Yu Bai et al.   ANALYST

Microfluidic Serial Dilution Cell-Based Assay for Analyzing Drug Dose Response over a Wide Concentration Range

(2010) Shinji Sugiura et al.   ANALYTICAL CHEMISTRY

On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices

(2010) Paul M. van Midwoud et al.   ANALYTICAL CHEMISTRY

Rapid, Semiautomated Quantification of Bacterial Cells in Freshwater by Using a Microfluidic Device for On-Chip Staining and Counting

(2010) Nobuyasu Yamaguchi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Endothelial cell behaviour within a microfluidic mimic of the flow channels of a modular tissue engineered construct

(2010) Omar F. Khan et al.   BIOMEDICAL MICRODEVICES

Cell Adhesion Strength Is Controlled by Intermolecular Spacing of Adhesion Receptors

(2010) C. Selhuber-Unkel et al.   BIOPHYSICAL JOURNAL

High-throughput screening and small animal models, where are we?

(2010) Jean Giacomotto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microfluidic droplets: new integrated workflows for biological experiments

(2010) Balint Kintses et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

3D microchannel co-culture: method and biological validation

(2010) Maret Bauer et al.   Integrative Biology

Regulating microenvironmental stimuli for stem cells and cancer cells using microsystems

(2010) Joong Yull Park et al.   Integrative Biology

Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device

(2010) Tomoaki Okuyama et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

A microfluidic brain slice perfusion chamber for multisite recording using penetrating electrodes

(2010) Alexander J. Blake et al.   JOURNAL OF NEUROSCIENCE METHODS

Detection of bacterial cells by impedance spectra via fluidic electrodes in a microfluidic device

(2010) Tao Zhu et al.   LAB ON A CHIP

Rapid thermal lysis of cells using silicon–diamond microcantilever heaters

(2010) Natalya Privorotskaya et al.   LAB ON A CHIP

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips

(2010) Sriram Kosuri et al.   NATURE BIOTECHNOLOGY

High-throughput in vivo vertebrate screening

(2010) Carlos Pardo-Martin et al.   NATURE METHODS

A microfluidic oligonucleotide synthesizer

(2010) Cheng-Chung Lee et al.   NUCLEIC ACIDS RESEARCH

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A microfluidic platform for electrical detection of DNA hybridization

(2010) M. Javanmard et al.   SENSORS AND ACTUATORS B-CHEMICAL

Review: Microfluidic applications in metabolomics and metabolic profiling

(2009) James R. Kraly et al.   ANALYTICA CHIMICA ACTA

Determination of Kinetic Parameters,Kmandkcat, with a Single Experiment on a Chip

(2009) Sachin Jambovane et al.   ANALYTICAL CHEMISTRY

Microfluidic Self-Sorting of Mammalian Cells to Achieve Cell Cycle Synchrony by Hydrophoresis

(2009) Sungyoung Choi et al.   ANALYTICAL CHEMISTRY

Development of a Disposable Microfluidic Biochip for Multiparameter Cell Population Measurements

(2009) Johanna Gottschamel et al.   ANALYTICAL CHEMISTRY

Polymer Microchips Integrating Solid-Phase Extraction and High-Performance Liquid Chromatography Using Reversed-Phase Polymethacrylate Monoliths

(2009) Jikun Liu et al.   ANALYTICAL CHEMISTRY

Microdevice for the isolation and enumeration of cancer cells from blood

(2009) Swee Jin Tan et al.   BIOMEDICAL MICRODEVICES

Establishing New Sites of Polarization by Microtubules

(2009) Nicolas Minc et al.   CURRENT BIOLOGY

Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans

(2009) Adela Ben-Yakar et al.   CURRENT OPINION IN NEUROBIOLOGY

A tag-less method of sorting stem cells from clinical specimens and separating mesenchymal from epithelial progenitor cells

(2009) Barbara Roda et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish andXenopus

(2009) Grant N. Wheeler et al.   DEVELOPMENTAL DYNAMICS

Transport-mediated angiogenesis in 3D epithelial coculture

(2009) Ryo Sudo et al.   FASEB JOURNAL

Spontaneous migration of cancer cells under conditions of mechanical confinement

(2009) Daniel Irimia et al.   Integrative Biology

From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures

(2009) Amy L. Paguirigan et al.   Integrative Biology

Transport of live yeast and zebrafish embryo on a droplet (“digital”) microfluidic platform

(2009) Sang Uk Son et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

(2009) Carlos P. Huang et al.   LAB ON A CHIP

Biological implications of polydimethylsiloxane-based microfluidic cell culture

(2009) Keil J. Regehr et al.   LAB ON A CHIP

Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans

(2009) S. Elizabeth Hulme et al.   LAB ON A CHIP

Droplet microfluidic technology for single-cell high-throughput screening

(2009) E. Brouzes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomagnetic separation and rapid detection of bacteria using bioluminescence and microfluidics

(2009) Jingmin Qiu et al.   TALANTA

Development of a flow-through system for the fish embryo toxicity test (FET) with the zebrafish (Danio rerio)

(2009) E. Lammer et al.   TOXICOLOGY IN VITRO

Integrated microfluidic systems for high-performance genetic analysis

(2009) Peng Liu et al.   TRENDS IN BIOTECHNOLOGY

Rapid detection of genetically modified organisms on a continuous-flow polymerase chain reaction microfluidics

(2008) Yuyuan Li et al.   ANALYTICAL BIOCHEMISTRY

Mass Spectrometry-Based Metabolomics: Accelerating the Characterization of Discriminating Signals by Combining Statistical Correlations and Ultrahigh Resolution

(2008) Erwan Werner et al.   ANALYTICAL CHEMISTRY

Cell Culture Models in Microfluidic Systems

(2008) Ivar Meyvantsson et al.   Annual Review of Analytical Chemistry

Methods in cell separation for biomedical application: cryogels as a new tool

(2008) Ashok Kumar et al.   Biomedical Materials

DNA hybridization detection in a microfluidic channel using two fluorescently labelled nucleic acid probes

(2008) Lingxin Chen et al.   BIOSENSORS & BIOELECTRONICS

Status of biomolecular recognition using electrochemical techniques

(2008) Omowunmi A. Sadik et al.   BIOSENSORS & BIOELECTRONICS

Interdigitated array microelectrodes based impedance biosensors for detection of bacterial cells

(2008) Madhukar Varshney et al.   BIOSENSORS & BIOELECTRONICS

Electrical detection and characterization of bacterial adhesion using electrochemical impedance spectroscopy-based flow chamber

(2008) Sonia Bayoudh et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Proteomic methods for drug target discovery

(2008) Lekha Sleno et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Large-scale microfabricated channel plates for high-throughput, fully automated DNA sequencing

(2008) Hidesato Kumagai et al.   ELECTROPHORESIS

Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling

(2008) Peter J. Mack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial Cell Migration in Stable Gradients of Vascular Endothelial Growth Factor A and Fibroblast Growth Factor 2

(2008) Irmeli Barkefors et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass spectrometry for the identification of the discriminating signals from metabolomics: Current status and future trends

(2008) Erwan Werner et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Gold nanoparticles for one step DNA extraction and real-time PCR of pathogens in a single chamber

(2008) Kwang Ho Cheong et al.   LAB ON A CHIP

Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging

(2008) Vernella Vickerman et al.   LAB ON A CHIP

Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics

(2008) James Q. Boedicker et al.   LAB ON A CHIP

Droplet microfluidics

(2008) Shia-Yen Teh et al.   LAB ON A CHIP

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

A multi-purpose microfluidic perfusion system with combinatorial choice of inputs, mixtures, gradient patterns, and flow rates

(2008) Gregory A. Cooksey et al.   LAB ON A CHIP

Chip–NMR biosensor for detection and molecular analysis of cells

(2008) Hakho Lee et al.   NATURE MEDICINE

Protein crystallization: from purified protein to diffraction-quality crystal

(2008) Naomi E Chayen et al.   NATURE METHODS

Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans

(2008) Kwanghun Chung et al.   NATURE METHODS

Activity-dependent site-specific changes of glutamate receptor composition in vivo

(2008) Andreas Schmid et al.   NATURE NEUROSCIENCE

Nucleic Acid Isothermal Amplification Technologies—A Review

(2008) Pooria Gill et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Integrated microfluidic bioprocessor for single-cell gene expression analysis

(2008) N. M. Toriello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast DNA sequencing on a microchip by a hybrid separation mechanism that gives 600 bases in 6.5 minutes

(2008) C. P. Fredlake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

(2008) G. Faure-Andre et al.   SCIENCE

A polyethylene glycol (PEG) microfluidic chip with nanostructures for bacteria rapid patterning and detection

(2008) Jinjiang Yu et al.   SENSORS AND ACTUATORS A-PHYSICAL

Applications of Metabolomics in Drug Discovery and Development

(2008) David S Wishart   Drugs in research & development

Electrical/electrochemical impedance for rapid detection of foodborne pathogenic bacteria

(2007) Liju Yang et al.   BIOTECHNOLOGY ADVANCES

Biomolecular gradients in cell culture systems

(2007) Thomas M. Keenan et al.   LAB ON A CHIP

Microfluidic chip for blood cell separation and collection based on crossflow filtration

(2007) X CHEN et al.   SENSORS AND ACTUATORS B-CHEMICAL