Updating the research on the chemopreventive and therapeutic role of the peptide lunasin

Detection of lunasin in quinoa (Chenopodium quinoa Willd.) and the in vitro evaluation of its antioxidant and anti-inflammatory activities

(2017) Guixing Ren et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells

(2017) Chris Shidal et al.   Oncotarget

Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production

(2017) Chia-Chien Hsieh et al.   PLoS One

Kunitz trypsin inhibitor in addition to Bowman-Birk inhibitor influence stability of lunasin against pepsin-pancreatin hydrolysis

(2016) Samuel J. Price et al.   FOOD RESEARCH INTERNATIONAL

Immunological Investigation for the Presence of Lunasin, a Chemopreventive Soybean Peptide, in the Seeds of Diverse Plants

(2016) Alaa A. Alaswad et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways

(2016) QIANQIAN JIANG et al.   ONCOLOGY REPORTS

Lunasin is a redox sensitive intrinsically disordered peptide with two transiently populated α-helical regions

(2016) Rihards Aleksis et al.   PEPTIDES

The Chemopreventive Peptide Lunasin Inhibits d-Galactose- Induced Experimental Cataract in Rats

(2016) Guangzhi Dai et al.   PROTEIN AND PEPTIDE LETTERS

Lunasin is a novel therapeutic agent for targeting melanoma cancer stem cells

(2016) Chris Shidal et al.   Oncotarget

Commercial processed soy-based food product contains glycated and glycoxidated lunasin proteoforms

(2016) Aida Serra et al.   Scientific Reports

An effective and simple procedure to isolate abundant quantities of biologically active chemopreventive Lunasin Protease Inhibitor Concentrate (LPIC) from soybean

(2015) Hari B. Krishnan et al.   FOOD CHEMISTRY

Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells

(2015) Maria Theresa E. Montales et al.   Genes and Nutrition

“Potential Health Benefits of Lunasin: A Multifaceted Soy-Derived Bioactive Peptide”

(2015) Vaibhao Kisanrao Lule et al.   JOURNAL OF FOOD SCIENCE

The protective role of the Bowman-Birk protease inhibitor in soybean lunasin digestion: the effect of released peptides on colon cancer growth

(2015) Elvia Cruz-Huerta et al.   Food & Function

The soybean-derived peptide lunasin inhibits non-small cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein

(2015) Elizabeth J. McConnell et al.   Oncotarget

Lunasin Inhibits Cell Proliferation via Apoptosis and Reduces the Production of Proinflammatory Cytokines in Cultured Rheumatoid Arthritis Synovial Fibroblasts

(2015) Shaohui Jia et al.   Biomed Research International

Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells

(2015) Maria Theresa E. Montales et al.   Genes and Nutrition

Up to 92 % increase of cancer-preventing lunasin in organic spring barley

(2014) Linda Legzdina et al.   Agronomy for Sustainable Development

Efficient Production of Native Lunasin with Correct N-terminal Processing by Using the pH-Induced Self-Cleavable Ssp DnaB Mini-intein System in Escherichia coli

(2014) Sarra Setrerrahmane et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Metformin for primary colorectal cancer prevention in patients with diabetes: A case-control study in a US population

(2014) Amikar Sehdev et al.   CANCER

In vitro chemo-protective effect of bioactive peptide lunasin against oxidative stress in human HepG2 cells

(2014) Samuel Fernández-Tomé et al.   FOOD RESEARCH INTERNATIONAL

Lunasin Sensitivity in Non-Small Cell Lung Cancer Cells Is Linked to Suppression of Integrin Signaling and Changes in Histone Acetylation

(2014) Junichi Inaba et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Off-line two dimensional isoelectrofocusing-liquid chromatography/mass spectrometry (time of flight) for the determination of the bioactive peptide lunasin

(2014) Miguel Guijarro-Díez et al.   JOURNAL OF CHROMATOGRAPHY A

Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer

(2014) Pratima Nangia-Makker et al.   PLoS One

Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice

(2014) Ahmed Al-Dwairi et al.   PLoS One

Activation of dendritic cell function by soypeptide lunasin as a novel vaccine adjuvant

(2014) Chun-Yu Tung et al.   VACCINE

The Role of Dietary Histone Deacetylases (HDACs) Inhibitors in Health and Disease

(2014) Shalome Bassett et al.   Nutrients

Lunasin-induced behavioural effects in mice: Focus on the dopaminergic system

(2013) Zane Dzirkale et al.   BEHAVIOURAL BRAIN RESEARCH

Soypeptide lunasin in cytokine immunotherapy for lymphoma

(2013) Hua-Chen Chang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antioxidant activity and protective effects of peptide lunasin against oxidative stress in intestinal Caco-2 cells

(2013) María José García-Nebot et al.   FOOD AND CHEMICAL TOXICOLOGY

Lunasin in wheat: A chemical and molecular study on its presence or absence

(2013) Giovanni Dinelli et al.   FOOD CHEMISTRY

Lunasin in cereal seeds: What is the origin?

(2013) Rowan A.C. Mitchell et al.   JOURNAL OF CEREAL SCIENCE

Detection of the lunasin peptide in oats (Avena sativa L)

(2013) Ilva Nakurte et al.   JOURNAL OF CEREAL SCIENCE

Endocytic Mechanism of Internalization of Dietary Peptide Lunasin into Macrophages in Inflammatory Condition Associated with Cardiovascular Disease

(2013) Anthony Cam et al.   PLoS One

The epigenome and cancer prevention: A complex story of dietary supplementation

(2012) Ho-Sun Lee et al.   CANCER LETTERS

Structural property of soybean lunasin and development of a method to quantify lunasin in plasma using an optimized immunoassay protocol

(2012) Vermont P. Dia et al.   FOOD CHEMISTRY

The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein

(2012) John Mark P. Pabona et al.   Genes and Nutrition

Discovery of lunasin peptide in triticale (X Triticosecale Wittmack)

(2012) Ilva Nakurte et al.   JOURNAL OF CEREAL SCIENCE

Analysis of Lunasin in Commercial and Pilot Plant Produced Soybean Products and an Improved Method of Lunasin Purification

(2012) Ariel Cavazos et al.   JOURNAL OF FOOD SCIENCE

Recombinant production of the therapeutic peptide lunasin

(2012) Stuart Kyle et al.   Microbial Cell Factories

RGD-peptide lunasin inhibits Akt-mediated NF-κB activation in human macrophages through interaction with the αVβ3 integrin

(2012) Anthony Cam et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Scalable Purification and Characterization of the Anticancer Lunasin Peptide from Soybean

(2012) Lauren E. Seber et al.   PLoS One

Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice

(2012) Ahmed Al-Dwairi et al.   PLoS One

Understanding the benefit of metformin use in cancer treatment

(2011) Ryan JO Dowling et al.   BMC Medicine

Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling

(2011) Vermont P. Dia et al.   CANCER LETTERS

Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells

(2011) Vermont P. Dia et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Relationship between lunasin's sequence and its inhibitory activity of histones H3 and H4 acetylation

(2011) Blanca Hernández-Ledesma et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Differential Expression of Thrombospondin (THBS1) in Tumorigenic and Nontumorigenic Prostate Epithelial Cells in Response to a Chromatin-Binding Soy Peptide

(2011) Alfredo F. Galvez et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Synthesis of the Cancer Preventive Peptide Lunasin by Lactic Acid Bacteria During Sourdough Fermentation

(2011) Carlo G. Rizzello et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Differential gene expression of RAW 264.7 macrophages in response to the RGD peptide lunasin with and without lipopolysaccharide stimulation

(2011) Vermont P. Dia et al.   PEPTIDES

Lunasin–Aspirin Combination Against NIH/3T3 Cells Transformation Induced by Chemical Carcinogens

(2011) Chia-Chien Hsieh et al.   PLANT FOODS FOR HUMAN NUTRITION

Lunasin peptide purified from Solanum nigrum L. protects DNA from oxidative damage by suppressing the generation of hydroxyl radical via blocking fenton reaction

(2010) Jin Boo Jeong et al.   CANCER LETTERS

Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression

(2010) Vermont P. Dia et al.   CANCER LETTERS

Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis

(2010) Chia-Chien Hsieh et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells

(2010) Chia-Chien Hsieh et al.   FOOD CHEMISTRY

Soybean Peptide Lunasin Suppresses In Vitro and In Vivo 7,12-Dimethylbenz[a]anthracene-Induced Tumorigenesis

(2010) Chia-Chien Hsieh et al.   JOURNAL OF FOOD SCIENCE

Amaranth lunasin-like peptide internalizes into the cell nucleus and inhibits chemical carcinogen-induced transformation of NIH-3T3 cells

(2010) Enrique Maldonado-Cervantes et al.   PEPTIDES

Complementary Roles in Cancer Prevention: Protease Inhibitor Makes the Cancer Preventive Peptide Lunasin Bioavailable

(2010) Chia-Chien Hsieh et al.   PLoS One

Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages

(2009) Blanca Hernández-Ledesma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isoflavone-deprived soy peptide suppresses mammary tumorigenesis by inducing apoptosis

(2009) Kyoungsook Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A high-protein soybean cultivar contains lower isoflavones and saponins but higher minerals and bioactive peptides than a low-protein cultivar

(2009) Luz Maria Paucar-Menacho et al.   FOOD CHEMISTRY

Optimisation of germination time and temperature on the concentration of bioactive compounds in Brazilian soybean cultivar BRS 133 using response surface methodology

(2009) Luz Maria Paucar-Menacho et al.   FOOD CHEMISTRY

Effect of time and temperature on bioactive compounds in germinated Brazilian soybean cultivar BRS 258

(2009) Luz Maria Paucar-Menacho et al.   FOOD RESEARCH INTERNATIONAL

Presence of Lunasin in Plasma of Men after Soy Protein Consumption

(2009) Vermont P. Dia et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lunasin, with an arginine-glycine-aspartic acid motif, causes apoptosis to L1210 leukemia cells by activation of caspase-3

(2009) Elvira Gonzalez de Mejia et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Cancer Preventive Seed Peptide Lunasin From Rye Is Bioavailable and Bioactive

(2009) Hyung Jin Jeong et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-κB pathway in the macrophage

(2009) Elvira Gonzalez de Mejia et al.   PEPTIDES

Pathways connecting inflammation and cancer

(2008) Paola Allavena et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Lunasin and Bowman-Birk protease inhibitor (BBI) in US commercial soy foods

(2008) Blanca Hernández-Ledesma et al.   FOOD CHEMISTRY

Isolation, purification and characterisation of lunasin from defatted soybean flour and in vitro evaluation of its anti-inflammatory activity

(2008) V.P. Dia et al.   FOOD CHEMISTRY

Bioactive Peptides in Amaranth (Amaranthus hypochondriacus) Seed

(2008) C. Silva-Sánchez et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lunasin, a novel seed peptide for cancer prevention

(2008) Blanca Hernández-Ledesma et al.   PEPTIDES

Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise

(2007) Naghma Khan et al.   ANTIOXIDANTS & REDOX SIGNALING