Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway

Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary

(2016) Hoon Jang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner

(2016) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation

(2015) Ahmed Soliman et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats

(2015) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Interleukin-17, oxidative stress, and inflammation: role of melatonin duringTrypanosoma cruziinfection

(2015) Vânia Brazão et al.   JOURNAL OF PINEAL RESEARCH

Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair

(2015) Carolina Alonso-González et al.   JOURNAL OF PINEAL RESEARCH

Potential utility of melatonin as an antioxidant therapy in the management of sickle cell anemia

(2015) Danilo Grünig Humberto da Silva et al.   JOURNAL OF PINEAL RESEARCH

Melatonin significantly improves the developmental competence of bovine somatic cell nuclear transfer embryos

(2015) Jianmin Su et al.   JOURNAL OF PINEAL RESEARCH

Melatonin-mediated inhibition of Purkinje neuron P-type Ca2+channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway

(2015) Yuan Zhang et al.   JOURNAL OF PINEAL RESEARCH

HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways

(2015) Chongxi Fan et al.   JOURNAL OF PINEAL RESEARCH

Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells

(2015) Seon Min Woo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin influences somatostatin secretion from human pancreaticδ-cells via MT1 and MT2 receptors

(2015) Juliane Zibolka et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances the occurrence of autophagy induced by oxidative stress inArabidopsisseedlings

(2015) Ping Wang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin modulates the fetal cardiovascular defense response to acute hypoxia

(2015) Avnesh S. Thakor et al.   JOURNAL OF PINEAL RESEARCH

Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation

(2015) Jia-Yi Wei et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates methamphetamine-induced inhibition of proliferation of adult rat hippocampal progenitor cellsin vitro

(2015) Kasima Ekthuwapranee et al.   JOURNAL OF PINEAL RESEARCH

Melatonin regulates the rhythmic migration of neutrophils in live zebrafish

(2015) Da-long Ren et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis

(2015) Leandro da Silva Borges et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

(2015) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells

(2015) Jiraporn Panmanee et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

miR-613 regulates cholesterol efflux by targeting LXRα and ABCA1 in PPARγ activated THP-1 macrophages

(2014) Ranzun Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Leptin Activates RhoA/ROCK Pathway to Induce Cytoskeleton Remodeling in Nucleus Pulposus Cells

(2014) Zheng Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17

(2014) Mayuri Shukla et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes

(2014) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

(2014) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling

(2014) In-Sik Shin et al.   JOURNAL OF PINEAL RESEARCH

Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study

(2013) Ahmad Omair et al.   BMC MUSCULOSKELETAL DISORDERS

Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant

(2013) You-Qiang Song et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells

(2013) Zheng Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways

(2013) Zheng Li et al.   PLoS One

MicroRNA-10b Promotes Nucleus Pulposus Cell Proliferation through RhoC-Akt Pathway by Targeting HOXD10 in Intervetebral Disc Degeneration

(2013) Xin Yu et al.   PLoS One

Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice

(2012) Chang-Ming Chern et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lumbar intervertebral disc degeneration associated with axial and radiating low back pain in ageing SPARC-null mice

(2012) Magali Millecamps et al.   PAIN

A Population-Based Study of Juvenile Disc Degeneration and Its Association with Overweight and Obesity, Low Back Pain, and Diminished Functional Status

(2011) Dino Samartzis et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro

(2011) Jie Fu et al.   JOURNAL OF PINEAL RESEARCH

Biomechanics of Intervertebral Disk Degeneration

(2011) Nozomu Inoue et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Implementation of a Guideline for Low Back Pain Management in Primary Care

(2011) Annette Becker et al.   SPINE

Modic changes and associated features in Southern European chronic low back pain patients

(2011) Estanislao Arana et al.   Spine Journal

Human Nucleus Pulposus Cells React to IL-6

(2010) Rebecca K. Studer et al.   SPINE

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

(2009) Aneta J. Pockert et al.   ARTHRITIS AND RHEUMATISM

Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation

(2009) M.D. Maldonado et al.   PHARMACOLOGICAL RESEARCH

Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc

(2008) Siyuan Li et al.   JOURNAL OF ANATOMY

Bone morphogenetic protein-7 protects human intervertebral disc cells in vitro from apoptosis

(2007) Aiqun Wei et al.   Spine Journal