Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary

Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells

(2015) P. Plaimee et al.   CELL PROLIFERATION

Melatonin-related genes expressed in the mouse uterus during early gestation promote embryo implantation

(2015) Changjiu He et al.   JOURNAL OF PINEAL RESEARCH

Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation

(2015) Roberto Pariente et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates intestinal ischemia–reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2

(2015) Bo Yang et al.   JOURNAL OF SURGICAL RESEARCH

Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice

(2015) Eun Mi Chang et al.   PLoS One

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Inhibits Endoplasmic Reticulum Stress and Epithelial-Mesenchymal Transition during Bleomycin-Induced Pulmonary Fibrosis in Mice

(2014) Hui Zhao et al.   PLoS One

Essential actions of melatonin in protecting the ovary from oxidative damage

(2014) M.H.C. Cruz et al.   THERIOGENOLOGY

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers

(2014) Shingo Nakahata et al.   Nature Communications

Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization In Vitro1

(2013) Tessa Lord et al.   BIOLOGY OF REPRODUCTION

Clinical relevance of melatonin in ovarian and placental physiology: a review

(2013) Russel J. Reiter et al.   GYNECOLOGICAL ENDOCRINOLOGY

Peripheral Reproductive Organ Health and Melatonin: Ready for Prime Time

(2013) Russel Reiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

(2013) Ulkan Kilic et al.   Nutrition & Metabolism

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Cyclophosphamide Triggers Follicle Activation and "Burnout"; AS101 Prevents Follicle Loss and Preserves Fertility

(2013) L. Kalich-Philosoph et al.   Science Translational Medicine

How do chemotherapeutic agents damage the ovary?

(2012) S. Morgan et al.   HUMAN REPRODUCTION UPDATE

Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells

(2012) Abdulhadi C. Uguz et al.   JOURNAL OF PINEAL RESEARCH

Subcellular targets of cisplatin cytotoxicity: An integrated view

(2012) Sandra M. Sancho-Martínez et al.   PHARMACOLOGY & THERAPEUTICS

Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells

(2011) Ji-Hyun Kim et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

(2011) Rüdiger Hardeland et al.   JOURNAL OF PINEAL RESEARCH

Functional roles of the phosphatidylinositol 3-kinases (PI3Ks) signaling in the mammalian ovary

(2011) Wenjing Zheng et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gαs and Gαq proteins

(2010) Stephen Y. W. Shiu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia

(2010) Shi-Young Park et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats

(2010) Kyung Hee Jung et al.   JOURNAL OF PINEAL RESEARCH

The Mammalian Ovary from Genesis to Revelation

(2009) Mark A. Edson et al.   ENDOCRINE REVIEWS

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles

(2009) Pradeep Reddy et al.   HUMAN MOLECULAR GENETICS

Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway

(2009) Sara Casado-Zapico et al.   JOURNAL OF PINEAL RESEARCH

Oocyte-Specific Deletion of Pten in Mice Reveals a Stage-Specific Function of PTEN/PI3K Signaling in Oocytes in Controlling Follicular Activation

(2009) Krishna Jagarlamudi et al.   PLoS One

Lim Homeobox Gene, Lhx8, Is Essential for Mouse Oocyte Differentiation and Survival1

(2008) Youngsok Choi et al.   BIOLOGY OF REPRODUCTION

Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth

(2008) George B. John et al.   DEVELOPMENTAL BIOLOGY

A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause

(2008) K. R. Hansen et al.   HUMAN REPRODUCTION

Understanding PTEN regulation: PIP2, polarity and protein stability

(2008) N R Leslie et al.   ONCOGENE

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE

Effects of melatonin on the endometrial morphology and embryo implantation in rats

(2007) Elisabete Lílian Dair et al.   FERTILITY AND STERILITY