Are positive allosteric modulators of α7 nAChRs clinically safe?

High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: Proof-of-concept

(2015) Joshua W. Gatson et al.   BRAIN RESEARCH BULLETIN

Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca2+release from the endoplasmic reticulum

(2015) María Guerra-Álvarez et al.   JOURNAL OF NEUROCHEMISTRY

A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia

(2013) Bopanna I Kalappa et al.   BRITISH JOURNAL OF PHARMACOLOGY

The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels

(2013) Bopanna I. Kalappa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Type-II Positive Allosteric Modulator of α7 nAChRs Reduces Brain Injury and Improves Neurological Function after Focal Cerebral Ischemia in Rats

(2013) Fen Sun et al.   PLoS One

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

(2011) Samantha L McLean et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes containing 11C-nicotine

(2010) J. E. Rose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA