Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects

Principles of agonist recognition in Cys-loop receptors

(2014) Timothy Lynagh et al.   Frontiers in Physiology

Structural insights into Cys-loop receptor function and ligand recognition

(2013) Mieke Nys et al.   BIOCHEMICAL PHARMACOLOGY

Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies

(2013) Anshul A. Pandya et al.   BIOCHEMICAL PHARMACOLOGY

The ?7 Nicotinic Acetylcholine Receptor Complex: One, Two or Multiple Drug Targets?

(2013) Morten S. Thomsen et al.   CURRENT DRUG TARGETS

The Activity of GAT107, an Allosteric Activator and Positive Modulator of α7 Nicotinic Acetylcholine Receptors (nAChR), Is Regulated by Aromatic Amino Acids That Span the Subunit Interface

(2013) Roger L. Papke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expeditious Synthesis, Enantiomeric Resolution, and Enantiomer Functional Characterization of (4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): An Allosteric Agonist-Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors

(2013) Ganesh A. Thakur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors

(2013) JasKiran K. Gill et al.   PLoS One

Discovery of positive allosteric modulators and silent allosteric modulators of the  -opioid receptor

(2013) N. T. Burford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a High-Throughput Calcium Flux Assay for Identification of All Ligand Types Including Positive, Negative, and Silent Allosteric Modulators for G Protein-Coupled Receptors

(2012) Devin J. Noblin et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Allosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery

(2012) Elena Mantione et al.   Future Medicinal Chemistry

A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance to spinosad inFrankliniella occidentalis

(2012) Alin M. Puinean et al.   JOURNAL OF NEUROCHEMISTRY

Nicotinic acetylcholine receptors: From basic science to therapeutics

(2012) Raymond Hurst et al.   PHARMACOLOGY & THERAPEUTICS

Structure and Pharmacology of Pentameric Receptor Channels: From Bacteria to Brain

(2012) Pierre-Jean Corringer et al.   STRUCTURE

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

(2011) Dustin K. Williams et al.   BIOCHEMICAL PHARMACOLOGY

Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization

(2011) Toby Collins et al.   NEUROPHARMACOLOGY

Agonist activation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2011) J. K. Gill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional diversity of native brain neuronal nicotinic receptors

(2009) Cecilia Gotti et al.   BIOCHEMICAL PHARMACOLOGY

In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of  7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile

(2009) J. Malysz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Neuronal nicotinic acetylcholine receptors: From the genetic analysis to neurological diseases

(2008) O.K. Steinlein et al.   BIOCHEMICAL PHARMACOLOGY

Diversity of vertebrate nicotinic acetylcholine receptors

(2008) Neil S. Millar et al.   NEUROPHARMACOLOGY

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA