The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat

Omecamtiv Mecarbil Modulates the Kinetic and Motile Properties of Porcine β-Cardiac Myosin

(2015) Yingying Liu et al.   BIOCHEMISTRY

Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure

(2014) Kristin Wilson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Analytical Comparison of Natural and Pharmaceutical Ventricular Myosin Activators

(2014) Yihua Wang et al.   BIOCHEMISTRY

Diaphragm dysfunction in heart failure is accompanied by increases in neutral sphingomyelinase activity and ceramide content

(2014) Hyacinth M. Empinado et al.   EUROPEAN JOURNAL OF HEART FAILURE

An overview of recent developments in the treatment of heart failure: update from the ESC Congress 2013

(2014) Miroslava Valentova et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Inotropes and Inodilators for Acute Heart Failure

(2014) László Nagy et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Sarcomere length nanometry in rat neonatal cardiomyocytes expressed with α-actinin–AcGFP in Z discs

(2014) Seine A. Shintani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling

(2014) Dóra Bodnár et al.   JOURNAL OF PHYSIOLOGY-LONDON

Small molecule-mediated refolding and activation of myosin motor function

(2014) Michael B Radke et al.   eLife

Omecamtiv mecarbil: a promising new drug in systolic heart failure

(2012) Matthijs F.L. Meijs et al.   EUROPEAN JOURNAL OF HEART FAILURE

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012

(2012) et al.   EUROPEAN JOURNAL OF HEART FAILURE

Mechanical and kinetic properties of β-cardiac/slow skeletal muscle myosin

(2012) Bernhard Brenner et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

The Calcium Sensitizer Levosimendan Improves Human Diaphragm Function

(2011) Jonne Doorduin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

(2011) John GF Cleland et al.   LANCET

Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

(2011) John R Teerlink et al.   LANCET

Translational medicine: To the rescue of the failing heart

(2011) Donald M. Bers et al.   NATURE

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Rapidly Progressive Diaphragmatic Weakness and Injury during Mechanical Ventilation in Humans

(2010) Samir Jaber et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart Failure

(2010) You-Tang Shen et al.   Circulation-Heart Failure

A novel approach to improve cardiac performance: cardiac myosin activators

(2009) John R. Teerlink   HEART FAILURE REVIEWS

EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation

(2009) Julien Ochala et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cardiac Ca2+ Signaling and Ca2+ Sensitizers

(2008) Masao Endoh   CIRCULATION JOURNAL