Article
Clinical Neurology
Gregory Jones, Carola Rong, Courtney M. Vecera, Christopher Gurguis, Roshan Chudal, Rushaniya Khairova, Edison Leung, Ana C. Ruiz, Lokesh Shahani, Marcus Zanetti, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: Lithium may play an important role in treating comorbid anxiety in bipolar disorder, both as adjunct and monotherapy. Lower doses of lithium may provide equivalent efficacy and enhance tolerability and compliance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Medicine, General & Internal
Julian Mutz, Umamah Choudhury, Jinlong Zhao, Alexandru Dregan
Summary: This study found elevated levels of frailty in individuals with three common mental disorders. Frailty and mental disorders represent modifiable targets for prevention and treatment, and improving population health and life expectancy, especially when both conditions coexist.
Article
Neurosciences
Luana Gilio, Diego Fresegna, Antonietta Gentile, Livia Guadalupi, Krizia Sanna, Francesca De Vito, Sara Balletta, Silvia Caioli, Francesca Romana Rizzo, Alessandra Musella, Ennio Iezzi, Alessandro Moscatelli, Giovanni Galifi, Roberta Fantozzi, Paolo Bellantonio, Roberto Furlan, Annamaria Finardi, Valentina Vanni, Ettore Dolcetti, Antonio Bruno, Fabio Buttari, Georgia Mandolesi, Diego Centonze, Mario Stampanoni Bassi
Summary: Exercise has an immunomodulatory effect in MS patients, reducing levels of proinflammatory cytokines and improving mood disorders. IL-2 plays a causal role in mood disorders and synaptic dysfunction in MS. Further studies are needed to investigate the long-term effects of exercise as a disease-modifying therapy in MS.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Psychology, Clinical
Ilona Merikanto, Timo Partonen
Summary: This study found that evening-types show more pronounced mental health symptoms, diagnoses, and hospital treatments, especially when assessed by circadian type. Insufficient sleep mediates most but not all of the associations between eveningness and mental health.
DEPRESSION AND ANXIETY
(2021)
Article
Multidisciplinary Sciences
Imtiyaz Ali Mir, Shang Kuan Ng, Muhammad Noh Zulfikri Mohd Jamali, Mohammed AbdulRazzaq Jabbar, Syeda Humayra
Summary: University students, particularly young adults, are more vulnerable to developing psychological distress, anxiety, and depression during the COVID-19 pandemic. This study aimed to investigate and compare the factors influencing and predicting mental health (anxiety and depression) during and after the COVID-19 lockdown among university students.
Article
Psychology, Multidisciplinary
Ana Jerkovic, Ana Prorokovic, Meri Matijaca, Jelena Vuko, Ana Poljicanin, Angela Mastelic, Ana Curkovic Katic, Vana Kosta, Lea Kustura, Kresimir Dolic, Zoran Dogas, Maja Rogic Vidakovic
Summary: The study examined the factor structure and correlates of the Hospital Anxiety and Depression Scale (HADS) in multiple sclerosis patients, finding it to be a reliable and valid self-assessment scale for monitoring the psychiatric and psychological status of patients with MS. The HADS subscales showed good internal consistencies and convergent validity, suggesting its use in clinical monitoring.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychology, Clinical
Sukanta Saha, Carmen C. W. Lim, Danielle L. Cannon, Lucinda Burton, Monique Bremner, Peter Cosgrove, Yan Huo, John J. McGrath
Summary: This study conducted a meta-analysis to explore the comorbidity between mood and anxiety disorders, finding consistent evidence of a substantial association regardless of diagnostic criteria, study timeframe, or adjustments. Clinicians should be aware of the high prevalence of this common comorbidity and ensure prompt identification and treatment.
DEPRESSION AND ANXIETY
(2021)
Article
Psychology, Clinical
Deepiksana Keerthy, Joht Singh Chandan, Juste Abramovaite, Krishna Margadhamane Gokhale, Siddhartha Bandyopadhyay, Ed Day, Steven Marwaha, Matthew R. Broome, Krishnarajah Nirantharakumar, Clara Humpston
Summary: This study investigates the relationship between cannabis exposure and the risks of mental illness diagnoses or treatment and finds that cannabis exposure is associated with an increased risk of developing mental health disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Larissa Gama-Chonlon, James M. Scanlan, Rebecca M. Allen
Summary: This retrospective study analyzed the medical records of 317 patients undergoing rTMS treatment and found that bipolar depressed (BD) patients had greater changes in PHQ-9 scores than unipolar depressed (UD) patients by treatment conclusion. There were no between-group differences in GAD-7 score changes. Unilateral treatment resulted in higher rates of remission and response for BD patients compared to UD patients.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Marsal Sanches, Linh K. Nguyen, Tong Han Chung, Paul Nestadt, Holly C. Wilcox, William H. Coryell, Jair C. Soares, Sudhakar Selvaraj
Summary: This study found an association between the severity of anxiety symptoms and suicidal thoughts and behaviors in patients with mood disorders. This highlights the need for suicide risk assessment in patients with mood disorders reporting anxiety symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Alexander Jordan, Pradeesh Sivapalan, Josefin Eklof, Jakob B. Vestergaard, Howraman Meteran, Mohamad Isam Saeed, Tor Biering-Sorensen, Anders Lokke, Niels Seersholm, Jens Ulrik Staehr Jensen
Summary: This study found that exposure to inhaled corticosteroids in COPD patients was associated with a slight to moderate increase in antidepressant use frequency and risk of psychiatric hospital admissions.
Article
Psychiatry
Ching-Fang Sun, Zeeshan Mansuri, Chintan Trivedi, Ramu Vadukapuram, Abhishek Reddy
Summary: The study aimed to evaluate the prevalence of demographic characteristics and psychiatric disorders in adolescents with and without homicidal ideation (HI). The results showed a higher prevalence of psychiatric illnesses such as depression, anxiety, and bipolar disorder in adolescents with HI in the inpatient setting. White and black races were more prevalent in patients with homicidal ideation.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Kim Wright, Mohammod Mostazir, Ella Bailey, Barnaby D. Dunn, Heather O'Mahen, Michaela Sibsey, Zoe Thomas
Summary: This study investigated the feasibility and acceptability of an adapted version of Behavioral Activation (BA) for bipolar depression in a UK outpatient sample. The results showed high retention in therapy, with participants reporting satisfaction with the intervention. No therapy-related serious adverse events or exacerbations in manic symptoms were reported. The pattern of change on outcome measures suggests potential clinical benefit. Therefore, adapted BA for bipolar depression is a feasible and acceptable approach that merits further investigation.
Article
Psychology, Clinical
Elizabeth S. Gromisch, Aaron P. Turner, Lindsay O. Neto, Jodie K. Haselkorn, Sarah A. Raskin
Summary: This study aimed to examine the criterion and ecological validity of a simplified version of the Memory for Intentions Test (MIST) as a screening tool for prospective memory (PM) in individuals with multiple sclerosis (MS). The results showed that Trial 3 and Trial 4 of the MIST had high classification accuracy, with Trial 4 significantly associated with appointment attendance and unemployment. Therefore, Trial 4 has the potential to serve as an initial screening tool for PM in MS patients.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Surgery
Alison W. Henderson, Aaron P. Turner, Chelsea Leonard, George Sayre, Bjoern Suckow, Sienna L. Williams, Daniel C. Norvell, Joseph M. Czerniecki
Summary: This study investigated patient and provider experiences discussing mortality risk in the context of amputation within the Veterans Health Administration. The findings showed that conversations about mortality were uncommon prior to amputation, but most providers viewed them as valuable. Some patients perceived these conversations as unnecessary, but many were open to engaging in the discussion. Therefore, providers should introduce the topic and provide the context for why mortality conversations may be valuable, while respecting patients' preferences.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Rehabilitation
Daniel C. Norvell, Mary Lou Thompson, Aaron Baraff, Wayne T. Biggs, Alison W. Henderson, Kathryn P. Moore, Aaron P. Turner, Rhonda Williams, Charles C. Maynard, Joseph M. Czerniecki
Summary: This study developed and validated a patient-specific multivariable prediction model to predict 12-month mobility at the time of initial post-amputation prosthetic prescription. The model is designed for patients who have undergone transtibial or transfemoral amputation due to complications of diabetes and/or peripheral artery disease. The study used retrospective data from a large Veteran's Affairs dataset and prospectively collected patient-reported mobility.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Rehabilitation
Karlyn A. Edwards, David E. Reed, Derek Anderson, Kaitlin Harding, Aaron P. Turner, Bosco Soares, Pradeep Suri, Rhonda M. Williams
Article
Clinical Neurology
Elizabeth S. Gromisch, Sarah A. Raskin, Lindsay O. Neto, Jodie K. Haselkorn, Aaron P. Turner
Summary: This study examines the factors related to attendance behaviors in multiple sclerosis (MS) appointments, including scheduling metrics, demographic and clinical factors, and behavioral factors. The findings suggest that short notice cancellations are related to clinic structure and situational factors, while no shows are more influenced by behavioral issues such as difficulty remembering appointments and high levels of distress.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Rehabilitation
Aaron P. Turner, Anne Arewasikporn, Eric J. Hawkins, Pradeep Suri, Stephen P. Burns, Steve L. Leipertz, Jodie K. Haselkorn
Summary: This study aimed to characterize patterns of prescription opioid use in individuals with multiple sclerosis (MS) and identify risk factors associated with chronic use. The results showed a decline in chronic opioid use over the study period, but it remains common among a substantial minority of MS patients. Prior chronic opioid use, history of pain condition, post-traumatic stress disorder, and rural residence were associated with a greater risk of chronic prescription opioid use.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Rehabilitation
Daniel C. C. Norvell, Aaron P. P. Turner, David C. C. Morgenroth, Alison W. W. Henderson, Elizabeth G. G. Halsne, Max Hurwitz, Joseph M. M. Czerniecki
Summary: The study aimed to examine gender disparities and potential factors influencing prosthesis prescription practices in veteran patients with their first major unilateral amputation due to diabetes or peripheral arterial disease. A retrospective cohort study was conducted using the VA Corporate Data Warehouse to compare prosthesis prescription rates and time to prescription between men and women veterans. The findings revealed that men were more likely to receive a prosthesis prescription compared to women, and men had a shorter time to prescription.
DISABILITY AND REHABILITATION
(2023)
Article
Clinical Neurology
Elizabeth S. Gromisch, Dawn M. Ehde, Lindsay O. Neto, Jodie K. Haselkorn, Thomas Agresta, Swapna S. Gokhale, Aaron P. Turner
Summary: This study aimed to develop a novel self-management program for persons with multiple sclerosis (MS), called Managing My MS My Way (M4W). The program was developed based on social cognitive theory and included evidence-based strategies. Stakeholders were involved in the development process to ensure usefulness and adoption. The study determined stakeholders' interest, program focus, delivery method, content, and potential barriers.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Rebecca I. Spain, Andrea Hildebrand, Carin S. Waslo, William D. Rooney, Joshua Emmons, Daniel L. Schwartz, Mark S. Freedman, M. Mateo Paz Soldan, Pavle Repovic, Andrew J. Solomon, John Rinker II, Mitchell Wallin, Jodie K. Haselkorn, Olaf Stuve, Robert H. Gross, Aaron P. Turner
Summary: This study aimed to evaluate the associations between cognitive assessment and brain volumes in progressive multiple sclerosis (MS), and determine if there were differences between the secondary progressive (SPMS) and primary progressive (PPMS) subtypes. The findings showed that there were varying patterns of correlation between brain volumes and cognitive tasks in progressive MS patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychology, Clinical
Tracy M. Anastas, Aaron P. Turner, Erica J. J. Ho, Melissa A. Day, Dawn M. Ehde, Mark P. Jensen, Rhonda M. Williams
Summary: This study validates the value of adding an open label phase after a clinical trial of pain treatments through the analysis of participant characteristics and potential benefits. The results show that a substantial portion of study participants chose to participate in the open label phase and reported it to be beneficial. Analyzing data from an open label phase can provide insights into important aspects of patient experience, barriers to and facilitators of care, and treatment preferences.
REHABILITATION PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Aaron P. Turner, Karlyn A. Edwards, Mark P. Jensen, Dawn M. Ehde, Melissa A. Day, Rhonda M. Williams
Summary: This study examined the impact of three behavioral interventions on substance use among chronic pain patients. The results showed that mindfulness meditation and hypnosis significantly reduced cannabis use, but had no significant effect on tobacco or alcohol use.
REHABILITATION PSYCHOLOGY
(2023)
Article
Clinical Neurology
Kara Link, Lindsey M. Knowles, Kevin N. Alschuler, Dawn M. Ehde
Summary: This study examined the prevalence and characteristics of cannabis use for pain management among adults with multiple sclerosis (MS) and chronic pain. Results showed that 27% of participants used cannabis, with the most common route of administration being oil/tincture. Cannabis users were younger and had higher levels of pain intensity, pain interference, and neuropathic pain.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Jillian M. R. Clark, Amber Keller, Jacqueline E. Maye, Amy J. Jak, Maya E. O'Neil, Rhonda M. Williams, Aaron P. Turner, Kathleen F. Pagulayan, Elizabeth W. Twamley
Summary: The study found that compensatory cognitive training (CCT) can improve depressive symptoms and post-traumatic stress disorder (PTSD) in post-9/11 veterans with a history of mild traumatic brain injury, with better effects observed in patients with cognitive and psychiatric functioning issues.
