Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors

The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice

(2012) Cecilia Csölle et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts

(2011) Pia Soronen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder

(2011) Lena Backlund et al.   BIPOLAR DISORDERS

Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts

(2011) Marianela Masin et al.   BRITISH JOURNAL OF PHARMACOLOGY

A new chapter in the field of memory: adult hippocampal neurogenesis

(2011) Muriel Koehl et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease

(2011) Zsuzsanna Hracskó et al.   Molecular Neurodegeneration

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

(2011) A.A. Boucher et al.   NEUROSCIENCE

Cortical Inhibition, Gamma-Aminobutyric Acid, and Major Depression: There Is Plenty of Smoke but Is There Fire?

(2010) Gerard Sanacora   BIOLOGICAL PSYCHIATRY

Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

(2010) Leanne Stokes et al.   FASEB JOURNAL

Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort

(2010) Catharina Lavebratt et al.   JOURNAL OF AFFECTIVE DISORDERS

ATP and the purine type 2 X7 receptor affect sleep

(2010) James M. Krueger et al.   JOURNAL OF APPLIED PHYSIOLOGY

P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide

(2010) Lei Zhang et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Depression: A repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition?

(2010) Karen Wager-Smith et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?

(2009) Elaine K. Green et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Variation inP2RX7candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples

(2009) Maria Grigoroiu-Serbanescu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor

(2009) Cécile Delarasse et al.   JOURNAL OF NEUROCHEMISTRY

Brain-Derived Neurotrophic Factor Signaling Modulates Cocaine Induction of Reward-Associated Ultrasonic Vocalization in Rats

(2009) S. N. Williams et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells

(2009) Kittikun Viwatpinyo et al.   NEUROSCIENCE LETTERS

Impaired Interleukin-1β and c-Fos Expression in the Hippocampus Is Associated with a Spatial Memory Deficit in P2X7 Receptor-Deficient Mice

(2009) Virginie F. Labrousse et al.   PLoS One

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach

(2008) Krisztina Hejjas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

(2008) Ana M. Basso et al.   BEHAVIOURAL BRAIN RESEARCH

Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments

(2008) Darrick T. Balu et al.   BRAIN RESEARCH

Functional evidence for presynaptic P2X7receptors in adult rat cerebrocortical nerve terminals

(2008) Susanna Alloisio et al.   FEBS LETTERS

Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons

(2008) M. Diaz-Hernandez et al.   JOURNAL OF CELL SCIENCE

Case–control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders

(2008) A McQuillin et al.   MOLECULAR PSYCHIATRY

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY

Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice

(2008) T. Deltheil et al.   NEUROPHARMACOLOGY

P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients

(2008) Geza Nagy et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Negative and positive allosteric modulators of the P2X7receptor

(2007) A D Michel et al.   BRITISH JOURNAL OF PHARMACOLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

CB1-cannabinoid receptors are involved in the modulation of non-synaptic [3H]serotonin release from the rat hippocampus

(2007) Tamás Balázsa et al.   NEUROCHEMISTRY INTERNATIONAL

The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment

(2007) Megan E. Kozisek et al.   NEUROPHARMACOLOGY

Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies

(2007) Megan E. Kozisek et al.   PHARMACOLOGY & THERAPEUTICS

Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: Studies in adult mice hippocampus

(2007) Thierry Deltheil et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR