EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination

Demyelination induced by oxidative stress is regulated by sphingosine 1-phosphate receptors

(2017) Sinead A. O'Sullivan et al.   GLIA

EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis

(2017) Aurélie S. Clottu et al.   Cell Reports

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells

(2017) Florian Wanke et al.   Cell Reports

The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems

(2016) Aleksandra Rutkowska et al.   CURRENT DRUG TARGETS

The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

(2016) Catherine O’Sullivan et al.   Journal of Neuroinflammation

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients

(2016) Peter J. Crick et al.   MOLECULAR NEUROBIOLOGY

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

(2016) Jiho Jang et al.   Nature Communications

The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages

(2016) Aleksandra Rutkowska et al.   Scientific Reports

Oxysterols regulate encephalitogenic CD4+ T cell trafficking during central nervous system autoimmunity

(2015) F. Chalmin et al.   JOURNAL OF AUTOIMMUNITY

Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling

(2015) C. O'Sullivan et al.   JOURNAL OF CELL SCIENCE

The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

(2014) Gaelle Elain et al.   GLIA

EBI2 regulates intracellular signaling and migration in human astrocyte

(2014) Aleksandra Rutkowska et al.   GLIA

Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor

(2014) Francois Gessier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures

(2014) Adam J. Pritchard et al.   PLoS One

25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

(2014) A. Reboldi et al.   SCIENCE

Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes

(2013) Luke M Healy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation

(2013) Alessandra di Penta et al.   PLoS One

Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses

(2012) Tangsheng Yi et al.   IMMUNITY

Genetics of Hereditary Spastic Paraplegias

(2012) Rebecca Schüle et al.   SEMINARS IN NEUROLOGY

Oxysterols as biomarkers in neurodegenerative diseases

(2011) Valerio Leoni et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model

(2011) Hye Jung Kim et al.   FASEB JOURNAL

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures

(2011) Graham K. Sheridan et al.   GLIA

EBI2 Operates Independently of but in Cooperation with CXCR5 and CCR7 To Direct B Cell Migration and Organization in Follicles and the Germinal Center

(2011) D. Gatto et al.   JOURNAL OF IMMUNOLOGY

EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues

(2011) L. M. Kelly et al.   JOURNAL OF IMMUNOLOGY

Interplay between LXR and Wnt/ -Catenin Signaling in the Negative Regulation of Peripheral Myelin Genes by Oxysterols

(2011) J. Makoukji et al.   JOURNAL OF NEUROSCIENCE

Liver X receptors regulate cholesterol homeostasis in oligodendrocytes

(2011) Katherine Nelissen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Oxysterols direct B-cell migration through EBI2

(2011) Changlu Liu et al.   NATURE

Oxysterols direct immune cell migration via EBI2

(2011) Sébastien Hannedouche et al.   NATURE

Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses

(2010) J. P. Pereira et al.   INTERNATIONAL IMMUNOLOGY

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

(2010) Matthias Heinig et al.   NATURE

CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5

(2009) C. Goizet et al.   BRAIN

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

(2009) Dominique Gatto et al.   IMMUNITY

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis

(2009) Rebecca Schüle et al.   JOURNAL OF LIPID RESEARCH

25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR

(2009) Amalia Trousson et al.   JOURNAL OF NEUROCHEMISTRY

Two novel CYP7B1 mutations in Italian families with SPG5: a clinical and genetic study

(2009) Chiara Criscuolo et al.   JOURNAL OF NEUROLOGY

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

White matter lesions in spastic paraplegia with mutations in SPG5/CYP7B1

(2009) Roberta Biancheri et al.   NEUROMUSCULAR DISORDERS

Oxysterols as markers of neurological disease – a review

(2009) Valerio Leoni   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION