Article
Clinical Neurology
Maryam Ghasemi-Kasman, Nasrin Nosratiyan, Mona Hashemian, Seyyed-Raheleh Ahmadian, Hadi Parsian, Sahar Rostami-Mansoor
Summary: The study demonstrated that intranasal administration of FTY720 can effectively reduce astrocyte activation and demyelination levels compared to oral administration. In addition, the concentration of FTY720 was higher in the brain tissue of rats receiving intranasal administration.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Marianna Mekhaeil, Melissa Jane Conroy, Kumlesh Kumar Dev
Summary: Metachromatic leukodystrophy (MLD) is a severe genetic leukodystrophy characterized by deficits in the arylsulfatase A gene (ARSA) and accumulation of sulfatide. In an ex vivo cerebellar slice culture model, sulfatide was found to induce demyelination through PARP-1 activation, oligodendrocyte loss, inflammation, and gliosis. Treatment with the PARP-1 inhibitor Olaparib attenuated sulfatide-induced effects, indicating its potential therapeutic utility in rare demyelinating diseases.
Article
Cell Biology
Anna Wolters, Judith Reuther, Philipp Gude, Thomas Weber, Carsten Theiss, Heike Vogelsang, Veronika Matschke
Summary: Out-of-hospital cardiac arrest (OHCA) is a major challenge in emergency medicine, with persistent brain injury being a leading cause of mortality in survivors. The study found that teriflunomide has a protective effect on hippocampal and cerebellar cells in organotypic slice cultures of rats, with hippocampal cultures showing a higher vulnerability to ischemic conditions and a more sensitive response to teriflunomide.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ranjithkumar Rajendran, Vinothkumar Rajendran, Mario Giraldo-Velasquez, Fevronia-Foivi Megalofonou, Fynn Gurski, Christine Stadelmann, Srikanth Karnati, Martin Berghoff
Summary: MS is a chronic inflammatory and degenerative disease of the central nervous system commonly affecting the cerebellum. FGFs and FGFRs are involved in demyelinating pathologies such as MS. Recent research shows that cell-specific deletion of FGFR1 has anti-inflammatory and neuroprotective effects in the cerebellum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Seyedmousa Motavallihaghi, Mojgan Ghaemipanaeian, Sara Soleimani Asl, Faeze Foroughi-Parvar, Amir Hossein Maghsood
Summary: This study aimed to investigate the effect of Toxoplasma gondii infection on a multiple sclerosis (MS) mouse model. The results showed that chronic toxoplasmosis could inhibit the development of MS, reduce clinical symptoms, and decrease the levels of inflammatory cells and cytokines. These findings suggest that chronic toxoplasmosis may have therapeutic potential for MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Lara-Jasmin Schroeder, Hauke Thiesler, Lina Gretenkort, Thiemo Malte Moellenkamp, Martin Stangel, Viktoria Gudi, Herbert Hildebrandt
Summary: Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. Polysialic acid (polySia) has been found to have the potential to promote remyelination in multiple sclerosis lesions by regulating Siglec-E-dependent microglia. In this study, polySia with different degrees of polymerization (DP) was applied, and it was found that polySia DP24-30 can improve remyelination by regulating microglia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Ala Ahrari, Maurice Meseke, Eckart Foerster
Summary: Granule cell dispersion (GCD) is considered a pathological feature of temporal lobe epilepsy. Early epileptiform activity may be linked to the development of chronic epilepsy, and electrical activity during neuronal migration and differentiation is believed to contribute to GCD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Virology
Lise Lamoureux, Babu Sajesh, Jessy A. Slota, Sarah J. Medina, Matthew Mayor, Kathy L. Frost, Bryce Warner, Kathy Manguiat, Heidi Wood, Darwyn Kobasa, Stephanie A. Booth
Summary: Neurological syndromes associated with COVID-19 suggest an effect of the virus on neuronal function, but the direct infection of SARS-CoV-2 in the brain remains under debate. In this study, using brain slice culture, researchers found that while some glial cells were infected, there was no evidence of viral infection or replication in neurons. These findings support previous clinical studies on neurological involvement in COVID-19 patients.
Article
Food Science & Technology
Ning Zhang, Lin Li, Sen Li, Muhammad Akram Khan, Adnan Hassan Tahir, Muhammad Farhan Rahim, Ting Wang, Jiyu Zhao, Ruiyan Zhang
Summary: The neuroprotective effects of beta-hydroxybutyrate (BHB) were explored in a demyelination model called the cuprizone model. BHB was found to reduce demyelination and promote M2 microglia polarization. It also improved blood-brain barrier dysfunction and influenced the expression of various related genes. These findings suggest that BHB could be a potential therapeutic approach for preventing demyelinating diseases.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, General & Internal
Liza Dewyse, Vincent De Smet, Stefaan Verhulst, Nathalie Eysackers, Rastislav Kunda, Nouredin Messaoudi, Hendrik Reynaert, Leo A. van Grunsven
Summary: Precision cut liver slices (PCLS) can serve as an exceptional in vitro liver model by retaining the complex physiological architecture of the native liver. Optimized PCLS cultures allow for drug-induced liver fibrosis modeling.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mirhan N. Makled, Ahmed R. El-Sheakh
Summary: The current study demonstrates the anti-inflammatory and antioxidant effects of fingolimod against Ova-induced allergic airway inflammation. Fingolimod inhibits inflammatory cell infiltration, eosinophils numbers, and concentrations of immunoglobulin E, sphingosine-1-phosphate, interleukin (IL)-4, and IL-13. It also reduces microvascular leakage, edema, and oxidative stress, along with downregulating mitogen activated kinases signaling and decreasing MCP-1 expression.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sangita Sutradhar, Anindita Deb, Shiv Shankar Singh
Summary: The study suggests the dose-dependent effects of melatonin in attenuating oxidative stress and suppressing splenocyte proliferation in diabetic mice.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Engineering, Biomedical
Hongliang Weng, Xiaoguang Liu, Yongying Ren, Yujian Li, XingDa Li
Summary: The study investigates the effect of fingolimod loaded niosomes on the cognitive impairment induced by sevoflurane. The results demonstrate that fingolimod loaded niosomes alleviate neuronal death and improve spatial short-term and long-term memory, effectively attenuating the cognitive impairment caused by sevoflurane.
BIOMEDICAL MICRODEVICES
(2022)
Review
Biochemistry & Molecular Biology
Liza Dewyse, Hendrik Reynaert, Leo A. van Grunsven
Summary: PCLS, described as a promising tool for studying chronic liver disease thirty-five years ago, retains complex 3D liver structures in vitro but has the disadvantage of inducing fibrotic response. Researchers have evaluated the potential and limitations of PCLS and summarized the progress since its invention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lin He, Chuxia Deng
Summary: Organotypic tissue slice culture has numerous advantages in anticancer drug development, including the preservation of cell repertoire, quick assessment of therapeutic efficacy, and the ability to select personalized treatment regimens. It is expected to become a potent platform for individualized drug screening.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Aleksandra Rutkowska, Kumlesh K. Dev, Andreas W. Sailer
CURRENT DRUG TARGETS
(2016)
Review
Pharmacology & Pharmacy
Martin Madill, Denise Fitzgerald, Kara E. O'Connell, Kumlesh K. Dev, Sanbing Shen, Una FitzGerald
DRUG DISCOVERY TODAY
(2016)
Article
Immunology
Sinead A. O'Sullivan, Fabrizio Gasparini, Anis K. Mir, Kumlesh K. Dev
JOURNAL OF NEUROINFLAMMATION
(2016)
Article
Neurosciences
Sinead A. O'Sullivan, Maria Velasco-Estevez, Kumlesh K. Dev
Article
Immunology
Sinead A. O'Sullivan, Kumlesh K. Dev
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Immunology
Aleksandra Rutkowska, Andreas W. Sailer, Kumlesh K. Dev
JOURNAL OF NEUROINFLAMMATION
(2017)
Review
Neurosciences
Sinead O'Sullivan, Kumlesh K. Dev
Editorial Material
Neurosciences
K. K. Dev, A. J. Irving
Article
Neurosciences
Priyanka Dutta, Leila Dargahi, Kara E. O'Connell, Ashini Bolia, Banu Ozkan, Andreas W. Sailer, Kumlesh K. Dev
NEUROSCIENCE LETTERS
(2018)
Article
Multidisciplinary Sciences
Cedric Misslin, Maria Velasco-Estevez, Marie Albert, Sinead A. O'Sullivan, Kumlesh K. Dev
Article
Neurosciences
Maria Velasco-Estevez, Sara O. Rolle, Myrthe Mampay, Kumlesh K. Dev, Graham K. Sheridan
Article
Neurosciences
Maria Velasco-Estevez, Kamal K. E. Gadalla, Nuria Linan-Barba, Stuart Cobb, Kumlesh K. Dev, Graham K. Sheridan
Article
Neurosciences
Sibylle Bechet, Sinead A. O'Sullivan, Justin Yssel, Steven G. Fagan, Kumlesh K. Dev
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Kapil Sharma, Kumlesh K. Dev
Summary: The role of altered myelin in the onset and development of schizophrenia and changes in myelin due to antipsychotics remains unclear. However, this study suggests that antipsychotics directly regulate glial cell dysfunction and exert a protective effect on myelin loss. These findings may have implications for the potential use of antipsychotics in Krabbe disease.
Article
Clinical Neurology
Marianna Mekhaeil, Melissa Jane Conroy, Kumlesh Kumar Dev
Summary: Metachromatic leukodystrophy (MLD) is a severe genetic leukodystrophy characterized by deficits in the arylsulfatase A gene (ARSA) and accumulation of sulfatide. In an ex vivo cerebellar slice culture model, sulfatide was found to induce demyelination through PARP-1 activation, oligodendrocyte loss, inflammation, and gliosis. Treatment with the PARP-1 inhibitor Olaparib attenuated sulfatide-induced effects, indicating its potential therapeutic utility in rare demyelinating diseases.