The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
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Title
The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
Authors
Keywords
Sphingosine-1 phosphate receptors (S1PRs), Siponimod (BAF312), Aastrocytes, Demyelination, Krabbe disease
Journal
Journal of Neuroinflammation
Volume 13, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-02-08
DOI
10.1186/s12974-016-0494-x
References
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Note: Only part of the references are listed.- Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling
- (2015) C. O'Sullivan et al. JOURNAL OF CELL SCIENCE
- The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes
- (2014) Gaelle Elain et al. GLIA
- EBI2 regulates intracellular signaling and migration in human astrocyte
- (2014) Aleksandra Rutkowska et al. GLIA
- In Situ Activation of Antigen-Specific CD8+ T Cells in the Presence of Antigen in Organotypic Brain Slices
- (2014) C. Ling et al. JOURNAL OF IMMUNOLOGY
- Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures
- (2014) Adam J. Pritchard et al. PLoS One
- Siponimod (BAF312) for the treatment of secondary progressive multiple sclerosis: Design of the phase 3 EXPAND trial
- (2014) L. Kappos et al. Multiple Sclerosis and Related Disorders
- Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes
- (2013) Luke M Healy et al. BRITISH JOURNAL OF PHARMACOLOGY
- Fingolimod phosphate promotes the neuroprotective effects of microglia
- (2013) Hiromi Noda et al. JOURNAL OF NEUROIMMUNOLOGY
- Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study
- (2013) Krzysztof Selmaj et al. LANCET NEUROLOGY
- Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator
- (2013) Shifeng Pan et al. ACS Medicinal Chemistry Letters
- Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-β1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis
- (2012) Le Yang et al. AMERICAN JOURNAL OF PATHOLOGY
- The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate
- (2012) P Gergely et al. BRITISH JOURNAL OF PHARMACOLOGY
- A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis
- (2012) Jean Quancard et al. CHEMISTRY & BIOLOGY
- Homeostatic function of astrocytes: Ca2+ and Na+ signalling
- (2012) Vladimir Parpura et al. Translational Neuroscience
- S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures
- (2011) Graham K. Sheridan et al. GLIA
- Fingolimod modulates microglial activation to augment markers of remyelination
- (2011) Samuel J Jackson et al. Journal of Neuroinflammation
- Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis
- (2011) Sarah Al-Izki et al. Multiple Sclerosis Journal
- CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system
- (2010) Carolin Prodinger et al. ACTA NEUROPATHOLOGICA
- Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices
- (2010) Veronique E. Miron et al. AMERICAN JOURNAL OF PATHOLOGY
- Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists
- (2010) Henri Mattes et al. ChemMedChem
- An update on sphingosine-1-phosphate and other sphingolipid mediators
- (2010) Henrik Fyrst et al. Nature Chemical Biology
- A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
- (2010) Ludwig Kappos et al. NEW ENGLAND JOURNAL OF MEDICINE
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
- (2010) J. W. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR
- (2009) Guangwei Liu et al. NATURE IMMUNOLOGY
- FTY720 modulates human oligodendrocyte progenitor process extension and survival
- (2007) Veronique E. Miron et al. ANNALS OF NEUROLOGY
- Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury
- (2007) Z. Zhang et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis
- (2007) Kumlesh K. Dev et al. PHARMACOLOGY & THERAPEUTICS
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