Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Activity — A Critical Update

Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond

(2016) Praveen Rao et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

COX-2 as a target for cancer chemotherapy

(2014) Nilanjan Ghosh et al.   Pharmacological Reports

Expression and translation of the COX-1b gene in human cells – no evidence of generation of COX-1b protein

(2013) Christina Reinauer et al.   BIOLOGICAL CHEMISTRY

Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo

(2012) Torsten Kniess et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2)

(2012) Sai Kiran Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Beyond azide–alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

(2012) Boris D. Zlatopolskiy et al.   CHEMICAL COMMUNICATIONS

Inflammation and Cancer: Chemical Approaches to Mechanisms, Imaging, and Treatment

(2012) Lawrence J. Marnett   JOURNAL OF ORGANIC CHEMISTRY

Maximal Standardized Uptake Value on FDG-PET Is Correlated With Cyclooxygenase-2 Expression in Patients With Lung Adenocarcinoma

(2011) Katsuhiko Shimizu et al.   ANNALS OF THORACIC SURGERY

Efficient sequential synthesis of PET Probes of the COX-2 inhibitor [11C]celecoxib and its major metabolite [11C]SC-62807 and in vivo PET evaluation

(2011) Misato Takashima-Hirano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Efficient synthesis and chiral separation of 11C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography

(2011) Tatsuya Kikuchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer

(2011) M. J. Uddin et al.   Cancer Prevention Research

11C-Labeled Analogs of Indomethacin Esters and Amides for Brain Cyclooxygenase-2 Imaging: Radiosynthesis, in Vitro Evaluation and in Vivo Characteristics in Mice

(2011) Yumi Yamamoto et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis and preliminary in vitro biological evaluation of new carbon-11-labeled celecoxib derivatives as candidate PET tracers for imaging of COX-2 expression in cancer

(2011) Mingzhang Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cyclooxygenase-2 inhibitors: a literature and patent review (2009 – 2010)

(2011) Baker Jawabrah Al-Hourani et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

In Vivo Expression of Cyclooxygenase-1 in Activated Microglia and Macrophages During Neuroinflammation Visualized by PET with 11C-Ketoprofen Methyl Ester

(2011) M. Shukuri et al.   JOURNAL OF NUCLEAR MEDICINE

Optimization of the reaction conditions for the preparation of 99mTc-celecoxib and its biological evaluation

(2011) N. Farouk et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease

(2010) Khaled R.A. Abdellatif et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective Visualization of Cyclooxygenase-2 in Inflammation and Cancer by Targeted Fluorescent Imaging Agents

(2010) Md. Jashim Uddin et al.   CANCER RESEARCH

General Method for the11C-Labeling of 2-Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in COXs Expression

(2010) Misato Takashima-Hirano et al.   CHEMISTRY-A EUROPEAN JOURNAL

Preparation of 125I-celecoxib with high purity as a possible tumor agent

(2010) K. M. El-Azony   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

[11C]diclofenac sodium: synthesis and PET assessment of transdermal penetration

(2010) Debora Petroni et al.   NUCLEAR MEDICINE AND BIOLOGY

Tetrabutylammonium fluoride-promoted α-[11C]methylation of α-arylesters: a simple and robust method for the preparation of 11C-labeled ibuprofen

(2010) Koichi Kato et al.   TETRAHEDRON LETTERS

[123I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation

(2010) Md. Jashim Uddin et al.   ACS Medicinal Chemistry Letters

Unusual base-catalyzed exchange in the synthesis of deuterated PF-2413873

(2009) Stuart J. Rozze et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis and evaluation of [123I]-indomethacin derivatives as COX-2 targeted imaging agents

(2009) Md. Jashim Uddin et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression

(2009) Yuji Kuge et al.   NUCLEAR MEDICINE AND BIOLOGY

The COXIB Experience: A Look in the Rearview Mirror

(2008) Lawrence J. Marnett   Annual Review of Pharmacology and Toxicology

Site specific chemical delivery of NSAIDs to inflamed joints: Synthesis, biological activity and γ-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites

(2008) Mange Ram Yadav et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor

(2008) Frank Wuest et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cyclooxygenases: structural and functional insights

(2008) Carol A. Rouzer et al.   JOURNAL OF LIPID RESEARCH

Can celecoxib affect P-glycoprotein-mediated drug efflux? A microPET study

(2008) Erik F.J. de Vries et al.   NUCLEAR MEDICINE AND BIOLOGY

Evaluation of [11C]rofecoxib as PET tracer for cyclooxygenase 2 overexpression in rat models of inflammation

(2007) Erik F.J. de Vries et al.   NUCLEAR MEDICINE AND BIOLOGY