7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders
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Title
7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders
Authors
Keywords
Flavonoids, Neurotrophin, BDNF, Mimetic compound, Receptor agonistic activity
Journal
Translational Neurodegeneration
Volume 5, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-01-06
DOI
10.1186/s40035-015-0048-7
References
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Note: Only part of the references are listed.- Activation of Muscular TrkB by its Small Molecular Agonist 7,8-Dihydroxyflavone Sex-Dependently Regulates Energy Metabolism in Diet-Induced Obese Mice
- (2015) Chi Bun Chan et al. CHEMISTRY & BIOLOGY
- 7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders
- (2015) X. Du et al. NEUROCHEMISTRY INTERNATIONAL
- Expansion of the dentate mossy fiber–CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus
- (2015) C. Isgor et al. NEUROSCIENCE
- Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor
- (2014) Xia Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Social Interaction Rescues Memory Deficit in an Animal Model of Alzheimer's Disease by Increasing BDNF-Dependent Hippocampal Neurogenesis
- (2014) Ya-Hsin Hsiao et al. JOURNAL OF NEUROSCIENCE
- 7,8-Dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cell death through modulating PI3K/Akt and JNK pathways
- (2014) Xiao-Hua Han et al. NEUROSCIENCE LETTERS
- 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis
- (2014) Orhan Tansel Korkmaz et al. NEUROSCIENCE LETTERS
- 7,8-Dihydroxyflavone, a Small Molecule TrkB Agonist, Improves Spatial Memory and Increases Thin Spine Density in a Mouse Model of Alzheimer Disease-Like Neuronal Loss
- (2014) Nicholas A. Castello et al. PLoS One
- Post-Injury Treatment with 7,8-Dihydroxyflavone, a TrkB Receptor Agonist, Protects against Experimental Traumatic Brain Injury via PI3K/Akt Signaling
- (2014) Chun-Hu Wu et al. PLoS One
- 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice
- (2013) E. Bollen et al. BEHAVIOURAL BRAIN RESEARCH
- Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease
- (2013) M. Jiang et al. HUMAN MOLECULAR GENETICS
- Protection of Spiral Ganglion Neurons from Degeneration Using Small-Molecule TrkB Receptor Agonists
- (2013) Q. Yu et al. JOURNAL OF NEUROSCIENCE
- 7,8-Dihydroxyflavone leads to survival of cultured embryonic motoneurons by activating intracellular signaling pathways
- (2013) Teresa Tsai et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity
- (2013) Xiaohua Han et al. NEUROCHEMISTRY INTERNATIONAL
- 7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease
- (2013) Zhentao Zhang et al. NEUROPSYCHOPHARMACOLOGY
- O-Methylated Metabolite of 7,8-Dihydroxyflavone Activates TrkB Receptor and Displays Antidepressant Activity
- (2013) Xia Liu et al. PHARMACOLOGY
- Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves
- (2013) A. W. English et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 7,8-Dihydroxyflavone Ameliorates Scopolamine-Induced Alzheimer-Like Pathologic Dysfunction
- (2013) Chong Chen et al. REJUVENATION RESEARCH
- 7,8,3′-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo
- (2012) Qing Yu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression
- (2012) Xia Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protective Effects of 7,8-Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress
- (2012) Vivek K. Gupta et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats
- (2012) Yan Zeng et al. JOURNAL OF NEUROCHEMISTRY
- L-Dopa Prodrugs: An Overview of Trends for Improving Parkinsons Disease Treatment
- (2011) Antonio Di Stefano et al. CURRENT PHARMACEUTICAL DESIGN
- 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome
- (2011) Rebecca A. Johnson et al. JOURNAL OF APPLIED PHYSIOLOGY
- Vulnerability to Depression: From Brain Neuroplasticity to Identification of Biomarkers
- (2011) A. Blugeot et al. JOURNAL OF NEUROSCIENCE
- 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease
- (2011) Latha Devi et al. NEUROPSYCHOPHARMACOLOGY
- 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats
- (2010) Raül Andero et al. HIPPOCAMPUS
- A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect
- (2010) Xia Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
- (2010) S.-W. Jang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals
- (2009) Bente K. Pedersen et al. EXPERIMENTAL PHYSIOLOGY
- Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
- (2009) Alan H Nagahara et al. NATURE MEDICINE
- Identification of a consensus site for TRAF6/p62 polyubiquitination
- (2008) Trafina Jadhav et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tandem Repeat Peptide Strategy for the Design of Neurotrophic Factor Mimetics
- (2008) Gareth Williams et al. CNS & Neurological Disorders-Drug Targets
- Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments
- (2008) Carla Cunha et al. NEUROBIOLOGY OF DISEASE
- BDNF as a pain modulator
- (2008) A MERIGHI et al. PROGRESS IN NEUROBIOLOGY
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