Review
Food Science & Technology
Isaac Amoah, Jia Jiet Lim, Emmanuel Ofori Osei, Michael Arthur, Phyllis Tawiah, Ibok Nsa Oduro, Margaret Saka Aduama-Larbi, Samuel Tetteh Lowor, Elaine Rush
Summary: Cocoa consumption for >= 2 weeks is associated with reductions in systolic and diastolic blood pressure. Chocolate has a greater effect on systolic blood pressure compared to cocoa beverage. Higher daily doses of flavanols and epicatechin result in better outcomes.
Article
Biology
Yu-Young Tsai, Chiu-Lun Shen, D. Dhananjaya, Ching-Yen Tsai, Woan-Yuh Tarn
Summary: Knockout of the RBM4 gene leads to foliation defects in the cerebellum and delayed motor learning in mice, which are similar to neurotrophin deficiency. RBM4 promotes the expression of BDNF and enhances BDNF-TrkB signaling. Prenatal supplementation with a TrkB agonist rescues cerebellar malformation and improves motor learning in RBM4 knockout mice.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiye Kang, Ziwei Wang, Eleonora Cremonini, Gwenaelle Le Gall, Matthew G. Pontifex, Michael Muller, David Vauzour, Patricia I. Oteiza
Summary: Mounting evidence shows that consuming a high-fat diet (HFD) and developing obesity can lead to changes in cognition and mood. However, certain dietary bioactives, such as (-)-epicatechin (EC), may help prevent obesity-related cognitive decline. This study investigated the effects of EC supplementation on HFD-induced obesity-associated alterations in memory and mood. The results demonstrate that EC can mitigate anxiety-related behaviors and impact BDNF and glucocorticoids-mediated signaling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Chiaki Ishii, Natsumi Shibano, Mio Yamazaki, Tomoki Arima, Yuna Kato, Yuki Ishii, Yo Shinoda, Yugo Fukazawa, Tetsushi Sadakata, Yoshitake Sano, Teiichi Furuichi
Summary: CAPS1 is a key molecule involved in vesicular exocytosis, but its role in synaptic plasticity and learning behavior remains unclear. Studies showed impaired synaptic plasticity and learning behavior in Caps1 cKO mice, with reduced docked vesicles in the hippocampal CA3 region and impaired long-term potentiation in CA1 and CA3 regions. These findings suggest that CAPS1 plays a crucial role in hippocampal synaptic release and plasticity, which is essential for hippocampus-associated learning.
SCIENTIFIC REPORTS
(2021)
Review
Biology
Tarek Amer, Lila Davachi
Summary: Pattern separation is the process by which highly similar stimuli or experiences in memory are represented by non-overlapping neural ensembles. It has been traditionally attributed to the hippocampus, but recent evidence suggests that it involves a network of brain regions. The 'cortico-hippocampal pattern separation' (CHiPS) framework proposes that cognitive control regions play a significant role in pattern separation, either by resolving interference in sensory regions or by directly modulating hippocampal processes.
Review
Neurosciences
Walace Gomes-Leal
Summary: The discovery of continuous neurogenesis in the adult mammalian brain has shifted the paradigm in neuroscience, with these new cells having important regulatory functions in the brain. Adult hippocampal neurogenesis plays a significant role in brain function, being closely associated with spatial learning, emotional behavior, and more.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Breno Picin Casagrande, Alessandra Mussi Ribeiro, Luciana Pellegrini Pisani, Debora Estadella
Summary: In a WTD rodent model, it was found that discontinuing obesogenic diets can increase anxiety-like behavior, reduce sociability, and increase hippocampal BDNF levels. Mature forms of BDNF may play a crucial role in this process.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Neurosciences
Orsolya Folsz, Stephanie Trouche, Vincent Croset
Summary: Although most neurons are generated embryonically, neurogenesis continues at low rates in certain brain areas throughout adulthood, such as the dentate gyrus of the hippocampus. Adult-born neurons in the dentate gyrus play a role in pattern separation and the encoding of episodic-like memories. They compete with mature neurons for input and output and regulate hippocampal activity. These neurons exhibit transient hyperexcitability and hyperplasticity during maturation, contributing to their recruitment by experiences. They support pattern separation during encoding and aid in the degradation of old connections, promoting generalization and preventing interference.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jianbo Xiu, Jiayu Li, Zeyue Liu, Hui Wei, Caiyun Zhu, Rongrong Han, Zijing Liu, Wanwan Zhu, Yan Shen, Qi Xu
Summary: Major depressive disorder (MDD) is a prevalent and devastating mental illness. The diagnosis of MDD currently lacks reliable biomarkers. This study identified and validated a potential DNA methylation biomarker for MDD in the Chinese Han population, and investigated its functional implications, which could improve the diagnosis and treatment of MDD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Gerd Kempermann
Summary: Adult hippocampal neurogenesis has significant impacts on brain function and cognition, including plasticity, memory consolidation, stress resilience, and affective behaviors. However, a comprehensive theory that integrates the effects of neurogenesis on connectomics is still lacking.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Sarah A. Abd El-Aal, Mohamed AbdElrahman, Ahmed M. Reda, Hassan Afify, Ghada M. Ragab, Amira A. El-Gazar, Sherihan Salaheldin Abdelhamid Ibrahim
Summary: Galangin (GAL) has been shown to have protective effects against DOX-induced neurotoxicity, improving cognitive/behavioral functions and enhancing the expression of the cell repair/growth index BDNF. GAL also has antioxidant and anti-inflammatory properties, suppressing the expression of inflammatory markers.
Article
Neurosciences
Daniel W. Grupe, Alexandra L. Barnes, Lauren Gresham, Andrew Kirvin-Quamme, Elizabeth Nord, Andrew L. Alexander, Heather C. Abercrombie, Stacey M. Schaefer, Richard J. Davidson
Summary: This study investigated the links between perceived stress, hippocampal volume, and behavioral pattern separation. The results showed that perceived stress and subjective stress reactivity were independently associated with poorer behavioral pattern separation. However, hippocampal volume did not have significant associations with either stress measure.
NEUROBIOLOGY OF STRESS
(2022)
Article
Neurosciences
Kathryn L. Kern, Thomas W. Storer, Karin Schon
Summary: The study found that aging and exercise have opposing effects on mnemonic discrimination task performance; in older adults, cardiorespiratory fitness may have differential effects on hippocampal subfield integrity.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Ozlem Saral, Huseyin Sahin, Sinan Saral, Mehmet Alkanat, Kerimali Akyildiz, Atilla Topcu, Adnan Yilmaz
Summary: The study found that bee pollen reduced anxiety-like behavior in rats but did not affect depression-like behavior. Additionally, bee pollen suppressed neuroinflammation and reduced oxidative stress and lipid peroxidation in hippocampal tissues. Moreover, bee pollen significantly increased the level of BDNF in the hippocampus.
NEUROSCIENCE LETTERS
(2022)
Article
Multidisciplinary Sciences
Guo Wanjia, Serra E. Favila, Ghootae Kim, Robert J. Molitor, Brice A. Kuhl
Summary: The study demonstrates that abrupt remapping of activity patterns in the human hippocampal CA3 and dentate gyrus resolves memory interference caused by similar memories, with the magnitude of decorrelation influenced by initial pattern overlap. Remapped activity patterns carry relatively more information about learned episodic associations, highlighting the learning-related significance of remapping.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
H. Mohammad, F. Marchisella, S. Ortega-Martinez, P. Hollos, K. Eerola, E. Komulainen, N. Kulesskaya, E. Freemantle, V. Fagerholm, E. Savontous, H. Rauvala, B. D. Peterson, H. van Praag, E. T. Coffey
MOLECULAR PSYCHIATRY
(2018)
Article
Medicine, Research & Experimental
C'iana Cooper, Hyo Youl Moon, Henriette van Praag
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2018)
Article
Neurosciences
Minjie Shen, Feifei Wang, Meng Li, Nirnath Sah, Michael E. Stockton, Joseph J. Tidei, Yu Gao, Tomer Korabelnikov, Sudharsan Kannan, Jason D. Vevea, Edwin R. Chapman, Anita Bhattacharyya, Henriette van Praag, Xinyu Zhao
NATURE NEUROSCIENCE
(2019)
Article
Neurosciences
Hyo Youl Moon, Sahar Javadi, Matthew Stremlau, Kyeong Jin Yoon, Benjamin Becker, Sung-Ung Kang, Xinyu Zhao, Henriette van Praag
Article
Neurosciences
Julia Terreros-Roncal, Miguel Flor-Garcia, Elena P. Moreno-Jimenez, Noemi Pallas-Bazarra, Alberto Rabano, Nirnath Sah, Henriette van Praag, Damiana Giacomini, Alejandro F. Schinder, Jesus Avila, Maria Llorens-Martin
JOURNAL OF NEUROSCIENCE
(2019)
Review
Behavioral Sciences
Michelle W. Voss, Carmen Soto, Seungwoo Yoo, Matthew Sodoma, Carmen Vivar, Henriette van Praag
TRENDS IN COGNITIVE SCIENCES
(2019)
Article
Neurosciences
Catherine A. Schweppe, Caitlin Burzynski, Subramaniam Jayanthi, Bruce Ladenheim, Jean Lud Cadet, Eliot L. Gardner, Zheng-Xiong Xi, Henriette van Praag, Amy Hauck Newman, Thomas M. Keck
PSYCHOPHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Yuyoung Joo, Yutong Xue, Yue Wang, Ross A. McDevitt, Nirnath Sah, Simone Bossi, Shuaikun Su, Seung Kyu Lee, Wei Peng, Aoji Xie, Yongqing Zhang, Yi Ding, Wai Lim Ku, Soumita Ghosh, Kenneth Fishbein, Weiping Shen, Richard Spencer, Kevin Becker, Keji Zhao, Mark P. Mattson, Henriette van Praag, Alexei Sharov, Weidong Wang
NATURE COMMUNICATIONS
(2020)
Review
Multidisciplinary Sciences
Xinyu Zhao, Henriette van Praag
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Thomas H. Lee, Brian R. Christie, Henriette van Praag, Kangguang Lin, Parco Ming-Fai Siu, Aimin Xu, Kwok-Fai So, Suk-yu Yau
Summary: This study found that low-dose AdipoRon treatment promoted hippocampal cell proliferation in mice, while high-dose AdipoRon treatment had detrimental effects on hippocampal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Julian M. Gaitan, Hyo Youl Moon, Matthew Stremlau, Dena B. Dubal, Dane B. Cook, Ozioma C. Okonkwo, Henriette van Praag
Summary: Research suggests that aerobic exercise training can increase plasma CTSB levels, and changes in CTSB are correlated with cognitive performance. BDNF levels decreased with exercise training, while klotho levels remained unchanged but were closely related to changes in VO(2)peak. Metabolomic analysis showed an increase in PUFAs, reductions in ceramides, sphingo- and phospholipids, as well as changes in gut microbiome metabolites and redox homeostasis with exercise training.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Viridiana Vargas-Castro, Ricardo Gomez-Diaz, Victor M. Blanco-Alvarez, Constantino Tomas-Sanchez, Alejandro Gonzalez-Vazquez, Ana Karina Aguilar-Peralta, Juan A. Gonzalez-Barrios, Daniel Martinez-Fong, Jose R. Eguibar, Carmen Vivar, Araceli Ugarte, Guadalupe Soto-Rodriguez, Eduardo Brambila, Lourdes Millan-Perez-Pena, Bertha Alicia Leon-Chavez
Summary: The study investigated the effects of chronic taurine administration from embryonic age to adulthood on neuroinflammation, cell proliferation, myelination, and motor impairment in taiep rats. Results showed that taurine decreased inflammation markers, increased cell proliferation, promoted myelination, and improved motor behavior in a region-specific manner.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Seungwoo Yoo, Matthew Stremlau, Alejandro Pinto, Hyewon Woo, Olivia Curtis, Henriette van Praag
Summary: This research found that combination treatment of atorvastatin and Captopril can accelerate memory extinction in adult mice, but does not affect hippocampal neurogenesis and vascularization. In middle-aged mice, the combo treatment does not improve spatial memory, but can reduce anxiety.
Editorial Material
Cell Biology
Alejandro Pinto, Henriette van Praag