Layered defense: how mucus and tight junctions seal the intestinal barrier

Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1

(2017) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Gut permeability and mucosal inflammation: bad, good or context dependent

(2017) R Ahmad et al.   Mucosal Immunology

Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease

(2016) J. Magarian Blander   FEBS Journal

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cosmcis an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk

(2016) Matthew R. Kudelka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?

(2016) Noortje Ijssennagger et al.   TRENDS IN MOLECULAR MEDICINE

Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease

(2016) Jing Sun et al.   Nutrients

Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease

(2016) Abigail Basson et al.   Frontiers in Immunology

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2

(2016) Marijn C. Visschedijk et al.   PLoS One

HNF4α Regulates Claudin-7 Protein Expression during Intestinal Epithelial Differentiation

(2015) Attila E. Farkas et al.   AMERICAN JOURNAL OF PATHOLOGY

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Intestinal deletion ofClaudin-7enhances paracellular organic solute flux and initiates colonic inflammation in mice

(2015) Hiroo Tanaka et al.   GUT

Microenvironmental control of stem cell fate in intestinal homeostasis and disease

(2015) Sujata Biswas et al.   JOURNAL OF PATHOLOGY

Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease

(2015) S C Nalle et al.   Mucosal Immunology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

(2015) Noortje Ijssennagger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Claudin switching: Physiological plasticity of the Tight Junction

(2015) Christopher T. Capaldo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mucin glycan foraging in the human gut microbiome

(2015) Louise E. Tailford et al.   Frontiers in Genetics

Proteomic Analysis of Proteins Surrounding Occludin and Claudin-4 Reveals Their Proximity to Signaling and Trafficking Networks

(2015) Karin Fredriksson et al.   PLoS One

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

IBD Candidate Genes and Intestinal Barrier Regulation

(2014) Declan F. McCole   INFLAMMATORY BOWEL DISEASES

RhoGTPases, actomyosin signaling and regulation of the Epithelial Apical Junctional Complex

(2014) Miguel Quiros et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission

(2013) Mirjana Rajilić-Stojanović et al.   INFLAMMATORY BOWEL DISEASES

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspectives on tight junction research

(2012) Jörg-Dieter Schulzke et al.   Annals of the New York Academy of Sciences

Myosin light chain kinase: pulling the strings of epithelial tight junction function

(2012) Kevin E. Cunningham et al.   Annals of the New York Academy of Sciences

Dynamic properties of the tight junction barrier

(2012) Christopher R. Weber   Annals of the New York Academy of Sciences

Notch in the Intestine: Regulation of Homeostasis and Pathogenesis

(2012) Taeko K. Noah et al.   Annual Review of Physiology

Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition

(2012) Masami Wada et al.   GASTROENTEROLOGY

What role does intestinal permeability have in ibd pathogenesis?

(2012) Jon Meddings   INFLAMMATORY BOWEL DISEASES

Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

(2012) Nina A. Hering et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

Predicted expansion of the claudin multigene family

(2011) Katsuhiko Mineta et al.   FEBS LETTERS

Inflammation and Disruption of the Mucosal Architecture in Claudin-7–Deficient Mice

(2011) Lei Ding et al.   GASTROENTEROLOGY

Colonic gene expression patterns of mucin muc2 knockout mice reveal various phases in colitis development1

(2011) Peng Lu et al.   INFLAMMATORY BOWEL DISEASES

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

(2011) Jessica M. Holmn Larsson et al.   INFLAMMATORY BOWEL DISEASES

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

(2011) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia

(2011) Alan S. Fanning et al.   MOLECULAR BIOLOGY OF THE CELL

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

(2010) Chin Wen Png et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

HNF4α and CDH1 are associated with ulcerative colitis in a Dutch cohort

(2010) Suzanne van Sommeren et al.   INFLAMMATORY BOWEL DISEASES

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

(2010) Huy Nguyen et al.   Jove-Journal of Visualized Experiments

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis

(2009) Michael Gersemann et al.   DIFFERENTIATION

Hepatocyte Nuclear Factor 4 , a Key Factor for Homeostasis, Cell Architecture, and Barrier Function of the Adult Intestinal Epithelium

(2009) A.-L. Cattin et al.   MOLECULAR AND CELLULAR BIOLOGY

Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

(2009) Susanne M. Krug et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

(2009) Mathieu Darsigny et al.   PLoS One

Tight junctions as targets of infectious agents

(2008) Julian A. Guttman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cytokine regulation of tight junctions

(2008) Christopher T. Capaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Actin motors that drive formation and disassembly of epithelial apical junctions

(2008) Andrei et al.   Frontiers in Bioscience-Landmark

Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease

(2008) Sung-Hoon Ahn et al.   INFLAMMATORY BOWEL DISEASES

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA