CXCR1/2 Inhibition Blocks and Reverses Type 1 Diabetes in Mice

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

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Macrophages and  -cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes

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In Vivo Detection of Peripherin-Specific Autoreactive B Cells during Type 1 Diabetes Pathogenesis

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Involvement of Suppressive B-Lymphocytes in the Mechanism of Tolerogenic Dendritic Cell Reversal of Type 1 Diabetes in NOD Mice

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Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival

(2013) Antonio Citro et al.   Current Diabetes Reports

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial: Metabolic and Immunologic Features at Baseline Identify a Subgroup of Responders

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The diagnosis of insulitis in human type 1 diabetes

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Reduced Blood Leukocyte and Neutrophil Numbers in the Pathogenesis of Type 1 Diabetes

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Immune therapy in type 1 diabetes mellitus

(2013) Åke Lernmark et al.   Nature Reviews Endocrinology

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Human Islets Express a Marked Proinflammatory Molecular Signature Prior to Transplantation

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Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice

(2012) Y. Yamada et al.   DIABETOLOGIA

Current status of chemokine receptor inhibitors in development

(2012) Marcello Allegretti et al.   IMMUNOLOGY LETTERS

Overview of the mechanisms regulating chemokine activity and availability

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CXCR1/2 inhibition enhances pancreatic islet survival after transplantation

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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

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Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells

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Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor

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Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes

(2011) S. A. Sarkar et al.   DIABETES

Serum CXCL1 concentrations are elevated in type 1 diabetes mellitus, possibly reflecting activity of anti-islet autoimmune activity

(2011) Kazuma Takahashi et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Transgenic expression of murine chemokine decoy receptor D6 by islets reveals the role of inflammatory CC chemokines in the development of autoimmune diabetes in NOD mice

(2011) G.-J. Lin et al.   DIABETOLOGIA

The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic Mice

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Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

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CCR2 and CCR5 chemokine receptors differentially influence the development of autoimmune diabetes in the NOD mouse

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Role of CCL2/MCP-1 in Islet Transplantation

(2010) Raffaella Melzi et al.   CELL TRANSPLANTATION

Islet inflammation and CXCL10 in recent-onset type 1 diabetes

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Cytokine production by islets in health and diabetes: cellular origin, regulation and function

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Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitus

(2009) Bradley J. Van Sickle et al.   CYTOKINE

Etanercept Treatment in Children With New-Onset Type 1 Diabetes: Pilot randomized, placebo-controlled, double-blind study

(2009) L. Mastrandrea et al.   DIABETES CARE

Preservation of  -Cell Function in Autoantibody-Positive Youth With Diabetes

(2009) C. J. Greenbaum et al.   DIABETES CARE

Chemokines and chemokine receptors: an overview

(2009) Raffaella Bonecchi   Frontiers in Bioscience-Landmark

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

(2008) A. P. Martin et al.   DIABETES

Chemokines and leukocyte traffic

(2008) Federica Sallusto et al.   NATURE IMMUNOLOGY

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE