TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota

Impact of patient characteristics on the clinical efficacy of mongersen (GED-0301), an oral Smad7 antisense oligonucleotide, in active Crohn's disease

(2016) G. Monteleone et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Oral pirfenidone protects against fibrosis by inhibiting fibroblast proliferation and TGF-β signaling in a murine colitis model

(2016) Guanwei Li et al.   BIOCHEMICAL PHARMACOLOGY

Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease

(2016) Karishma Kamdar et al.   Cell Host & Microbe

TGF-β in tolerance, development and regulation of immunity

(2016) Chris J.C. Johnston et al.   CELLULAR IMMUNOLOGY

Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis

(2016) Silvia Speca et al.   INFLAMMATORY BOWEL DISEASES

Granulocytes and monocytes apheresis induces upregulation of TGFβ1in patients with active ulcerative colitis: A possible involvement of soluble HLA-I

(2016) Paola Contini et al.   JOURNAL OF CLINICAL APHERESIS

TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota

(2016) Sozaburo Ihara et al.   JOURNAL OF IMMUNOLOGY

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

(2016) T M Fenton et al.   Mucosal Immunology

Targeting the complex interactions between microbiota, host epithelial and immune cells in inflammatory bowel disease

(2016) Yoshihiro Hirata et al.   PHARMACOLOGICAL RESEARCH

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

(2016) Lingling Jiang et al.   Nature Communications

Suppressing TGF  Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer

(2015) H. Oshima et al.   CANCER RESEARCH

Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells

(2015) Ikkou Kashiwagi et al.   IMMUNITY

Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

(2015) Darren Ruane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Noncanonical STAT3 Activation Regulates Excess TGF-β1 and Collagen I Expression in Muscle of Stricturing Crohn’s Disease

(2015) Chao Li et al.   JOURNAL OF IMMUNOLOGY

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

(2014) Arvind Panday et al.   Cellular & Molecular Immunology

Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

(2014) Yoshiyuki Goto et al.   IMMUNITY

Severe inflammatory bowel disease associated with congenital alteration of transforming growth factor beta signaling

(2014) Samuele Naviglio et al.   Journal of Crohns & Colitis

Myeloid TGF-β signaling contributes to colitis-associated tumorigenesis in mice

(2013) Jingyi Li et al.   CARCINOGENESIS

The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

(2013) Paolo Biancheri et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Increased Activation of Latent TGF-β1 by αVβ3 in Human Crohnʼs Disease and Fibrosis in TNBS Colitis Can Be Prevented by Cilengitide

(2013) Chao Li et al.   INFLAMMATORY BOWEL DISEASES

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of Dextran Sodium Sulfate-Induced Inflammation and Colonic Tumorigenesis in Smad3−/− Mice with Dysregulated TGFβ

(2013) Audrey Seamons et al.   PLoS One

Tolerogenic and Activatory Plasmacytoid Dendritic Cells in Autoimmunity

(2013) Leslie Guéry et al.   Frontiers in Immunology

Proteases and the gut barrier

(2012) Paolo Biancheri et al.   CELL AND TISSUE RESEARCH

Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

(2012) Frederic A. Carvalho et al.   Cell Host & Microbe

E-cadherin: From epithelial glue to immunological regulator

(2012) Jan Van den Bossche et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cell-Specific Disruption of TGF-  Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

(2012) R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

Phase I Clinical Trial of Smad7 Knockdown Using Antisense Oligonucleotide in Patients With Active Crohn's Disease

(2012) Giovanni Monteleone et al.   MOLECULAR THERAPY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

(2012) Nu Zhang et al.   NATURE IMMUNOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs

(2011) J. Van den Bossche et al.   BLOOD

Smad7 Expression in T cells Prevents Colitis-Associated Cancer

(2011) A. Rizzo et al.   CANCER RESEARCH

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

(2011) Seth M. Bloom et al.   Cell Host & Microbe

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

(2011) Reena Rani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β

(2011) Joanne E Konkel et al.   NATURE IMMUNOLOGY

Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

(2010) Wendy S. Garrett et al.   Cell Host & Microbe

E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis

(2010) Karima R.R. Siddiqui et al.   IMMUNITY

Overcoming the hurdles in using mouse genetic models that block TGF-β signaling

(2010) Shomyseh Sanjabi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Bacterial Infection of Smad3/Rag2 Double-Null Mice with Transforming Growth Factor-β Dysregulation as a Model for Studying Inflammation-Associated Colon Cancer

(2009) Lillian Maggio-Price et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Transforming growth factor   signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures

(2009) A Di Sabatino et al.   GUT

Low counts of Faecalibacterium prausnitzii in colitis microbiota

(2009) H. Sokol et al.   INFLAMMATORY BOWEL DISEASES

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

(2009) Miriam Beer Torchinsky et al.   NATURE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

Blockade of transforming growth factor   upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa

(2008) A. Di Sabatino et al.   GUT

Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases

(2008) C. N Bernstein et al.   GUT

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY