Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs

ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells

(2016) Yukako Tsuchiya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cell-Cell Sensing of Viral Infection by Plasmacytoid Dendritic Cells

(2016) Brian Webster et al.   JOURNAL OF VIROLOGY

CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation

(2015) H-Y Kim et al.   CELL DEATH AND DIFFERENTIATION

CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation

(2015) Mi-Yeon Kim et al.   GLIA

The Methylcytosine Dioxygenase Tet2 Promotes DNA Demethylation and Activation of Cytokine Gene Expression in T Cells

(2015) Kenji Ichiyama et al.   IMMUNITY

Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

(2015) Ruili Yang et al.   IMMUNITY

Plasmacytoid dendritic cells promote HIV-1–induced group 3 innate lymphoid cell depletion

(2015) Zheng Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

(2015) Soung-Hoon Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

(2015) Zihou Deng et al.   NATURE IMMUNOLOGY

Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

(2015) M. J. Ciancanelli et al.   SCIENCE

mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines

(2015) Li He et al.   VIROLOGICA SINICA

Chromatin Contributions to the Regulation of Innate Immunity

(2014) Stephen T. Smale et al.   Annual Review of Immunology

Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming

(2014) Xiao Hu et al.   Cell Stem Cell

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

TET proteins and 5-methylcytosine oxidation in hematological cancers

(2014) Myunggon Ko et al.   IMMUNOLOGICAL REVIEWS

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

(2014) Sarah L. Rowland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Plasmacytoid Dendritic Cell as the Swiss Army Knife of the Immune System: Molecular Regulation of Its Multifaceted Functions

(2014) Julien J. Karrich et al.   JOURNAL OF IMMUNOLOGY

Coregulation of Transcription Factor Binding and Nucleosome Occupancy through DNA Features of Mammalian Enhancers

(2014) Iros Barozzi et al.   MOLECULAR CELL

DNA Methylation in Mammals

(2014) E. Li et al.   Cold Spring Harbor Perspectives in Biology

Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

(2014) Guangming Li et al.   PLoS Pathogens

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection

(2013) Hannah K. Long et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Networking at the Level of Host Immunity: Immune Cell Interactions during Persistent Viral Infections

(2013) Cherie T. Ng et al.   Cell Host & Microbe

Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription

(2013) Minna U. Kaikkonen et al.   MOLECULAR CELL

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

(2013) Myunggon Ko et al.   NATURE

CpG Island Chromatin Is Shaped by Recruitment of ZF-CxxC Proteins

(2013) N. P. Blackledge et al.   Cold Spring Harbor Perspectives in Biology

Plasmacytoid Dendritic Cells Contribute to Systemic but Not Local Antiviral Responses to HSV Infections

(2013) Melissa Swiecki et al.   PLoS Pathogens

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation

(2013) Mario Iurlaro et al.   GENOME BIOLOGY

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development

(2012) H. S. Li et al.   BLOOD

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

(2012) Yufei Xu et al.   CELL

Downregulation but lack of promoter hypermethylation or somatic mutations of the potential tumor suppressorCXXC5in MDS and AML with deletion 5q

(2012) Marianne B. Treppendahl et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Plasmacytoid dendritic cells control T-cell response to chronic viral infection

(2012) L. Cervantes-Barragan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cells: Arbiters of Immunity and Immunological Tolerance

(2012) K. L. Lewis et al.   Cold Spring Harbor Perspectives in Biology

Slc15a4, a Gene Required for pDC Sensing of TLR Ligands, Is Required to Control Persistent Viral Infection

(2012) Amanda L. Blasius et al.   PLoS Pathogens

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

(2011) Boris Reizis et al.   Annual Review of Immunology

CpG island chromatin

(2011) Neil P. Blackledge et al.   Epigenetics

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Plasmacytoid Dendritic Cells Are Crucial for the Initiation of Inflammation and T Cell Immunity In Vivo

(2011) Hideaki Takagi et al.   IMMUNITY

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

(2011) Yufei Xu et al.   MOLECULAR CELL

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

(2011) Tian-Peng Gu et al.   NATURE

Continuous Expression of the Transcription Factor E2-2 Maintains the Cell Fate of Mature Plasmacytoid Dendritic Cells

(2010) Hiyaa S. Ghosh et al.   IMMUNITY

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

(2010) Melissa Swiecki et al.   IMMUNITY

A Novel Wilms Tumor 1 (WT1) Target Gene Negatively Regulates the WNT Signaling Pathway

(2010) Myoung Shin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis

(2009) F. Pendino et al.   BLOOD

TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN

(2009) J. Di Domizio et al.   BLOOD

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

(2009) Vladimir R. Ramirez-Carrozzi et al.   CELL

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The CXXC finger 5 protein is required for DNA damage-induced p53 activation

(2009) Min Zhang et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

CXXC5 Is a Novel BMP4-regulated Modulator of Wnt Signaling in Neural Stem Cells

(2008) Therese Andersson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

(2008) Scott H Robbins et al.   GENOME BIOLOGY