Article
Immunology
Mandy I. Cheng, Joey H. Li, Luke Riggan, Bryan Chen, Rana Yakhshi Tafti, Scott Chin, Feiyang Ma, Matteo Pellegrini, Haley Hrncir, Arthur P. Arnold, Timothy E. O'Sullivan, Maureen A. Su
Summary: The outcomes of viral infections are influenced by sex, with males being more susceptible. Surprisingly, males have increased numbers of antiviral natural killer (NK) cells. However, these NK cells in males display decreased effector function compared to females in both mice and humans. The differences are not solely dependent on gonadal hormones and are associated with lower levels of UTX, an epigenetic regulator, in male NK cells. On the other hand, NK cell-intrinsic UTX deficiency in female mice increases NK cell numbers and reduces effector responses, leading to increased lethality to mouse cytomegalovirus.
Review
Hematology
Andrew B. Das, Carlos C. Smith-Diaz, Margreet C. M. Vissers
Summary: The development of epigenetic therapies has shown promise in diseases like acute myeloid leukemia, but issues such as patient response heterogeneity and resistance may be partly attributed to epigenetic heterogeneity. Combination therapy targeting both driver mutations and epigenetic plasticity could be a key strategy in addressing these challenges.
Article
Microbiology
Wan-Shan Yang, Wayne W. Yeh, Mel Campbell, Lung Chang, Pei-Ching Chang
Summary: KDM4A is a histone lysine demethylase known as an oncogene in various cancers, mediating important epigenetic regulation in tumorigenesis. Through the use of KSHV as a model, it was discovered that KIKAT/LINC01061 triggers the shifting of KDM4A, potentially acting as an epigenetic mechanism in gene transactivation.
Article
Hematology
Audrey Astori, Gabriel Matherat, Isabelle Munoz, Emilie-Fleur Gautier, Didier Surdez, Yael Zermati, Frederique Verdier, Sakina Zaidi, Vincent Feuillet, Amir Kadi, Evelyne Lauret, Olivier Delattre, Carine Lefevre, Michaela Fontenay, Evelyne Segal-Bendirdjian, Isabelle Dusanter-Fourt, Didier Bouscary, Olivier Hermine, Patrick Mayeux, Frederic Pendino
Summary: The gene CXXC5, located in a commonly deleted region in myelodysplastic syndrome and acute myeloid leukemia, plays a role as a tumor suppressor and accelerates erythrocyte maturation by upregulating SMAD7 expression. RINF may fine-tune cell sensitivity to TGF beta superfamily cytokines in both normal and pathological erythropoiesis.
Article
Ophthalmology
Yuhong Chen, Xinyue Zhu, Fuxiang Ye, Hong Wang, Xiaoling Wan, Ting Zhang, Yuwei Wang, Yimin Wang, Xiaohuan Zhao, Xinyue Bai, Yushu Xiao, Xiaodong Sun
Summary: This study established a novel CNV mouse model by subretinally injecting MDA-modified POS, which simulates the AMD pathological process. Results showed that MDA-modified POS induced CNV and RPE atrophy, increased VEGF expression, disrupted RPE cell junctions, and caused autophagy-lysosomal impairment in RPE cells.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Cell Biology
Yafang Wang, Yang Liu, Shu Liu, Xiaomeng Li, Xinxin Liu, Ming Jiao, Yuqin Yang, Xueting Luo, Fenghua Wang, Xiaoling Wan, Xiaodong Sun
Summary: This study generated a new Cyp4v3(-/-) mouse model using CRISPR/Cas9 technology to investigate the pathogenesis of Bietti crystalline dystrophy (BCD). The model effectively exhibited age-related progression that mimicked human ocular phenotypes, and identified abnormal lipid metabolism, inflammation activation and oxidative stress caused by Cyp4v3 defect. The study demonstrated that this model could serve as a useful tool for evaluating the effect of drugs and gene therapy in BCD.
DISEASE MODELS & MECHANISMS
(2022)
Article
Cell Biology
Shiqi Yang, Tong Li, Huixun Jia, Min Gao, Yiming Li, Xiaoling Wan, Zhen Huang, Min Li, Yuanqi Zhai, Xiaomeng Li, Xiaotong Yang, Tao Wang, Jian Liang, Qing Gu, Xueting Luo, Lei Qian, Shujie Lu, Junjian Liu, Yanping Song, Fenghua Wang, Xiaodong Sun, Dechao Yu
Summary: Antiangiogenesis therapies targeting VEGF have revolutionized the treatment of neovascular ocular diseases. This study reports the preclinical assessment and phase 1 clinical outcomes of a bispecific fusion protein, efdamrofusp alfa, which showed superior efficacy over anti-VEGF monotherapy in a mouse model. These findings suggest that efdamrofusp alfa may be effective for treating neovascular ocular diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Letter
Biochemistry & Molecular Biology
Shu Liu, Xiaoyue Duan, Feng Peng, Yafang Wang, Yang Liu, Xiaoling Wan, Jingfa Zhang, Xiaosa Li, Xiaodong Sun
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Dalil Hannani, Estelle Leplus, David Laurin, Benjamin Caulier, Caroline Aspord, Natacha Madelon, Ekaterina Bourova-Flin, Christian Brambilla, Elisabeth Brambilla, Anne-Claire Toffart, Karine Laulagnier, Laurence Chaperot, Joel Plumas
Summary: The purpose of ICI-based therapies is to help the patient's immune system combat tumors. Therapeutic vaccines with dendritic cells have not shown significant benefit, so a new vaccine based on an allogeneic dendritic cell line has been developed. This new vaccine demonstrates efficient activation of specific T cells and the synergistic effect of anti-PD-1 antibodies, showing potential for NSCLC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yi Lu, Yi Wang, Yang Wang, Yu Wu, Yazhuo Huang, Xingtong Liu, Shuo Zhang, Sisi Zhong, Yinwei Li, Bin Li, Jing Sun, Sijie Fang, Huifang Zhou
Summary: This study investigated the immunophenotypes of orbital-infiltrating macrophages and their modulatory effects on orbital fibroblasts (OFs) in Graves' orbitopathy (GO). The results showed the presence of different immunophenotypes of macrophages in GO orbital connective tissues and their promotion effects on OFs through the IL-6/sIL-6R signaling pathway. These findings provide molecular rationale for the potential therapeutic use of blocking sIL-6R in GO.
Article
Immunology
Eleonora Sosa Cuevas, Benoit Roubinet, Stephane Mouret, Michel Thepaut, Florence de Fraipont, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Caroline Aspord
Summary: Subversion of immunity is a hallmark of cancer development. Tumor cells exploit dendritic cells' versatility to subvert their functions. The glycosylation patterns of melanoma tumor cells are associated with immune evasion, and targeting specific glycans can restore dendritic cells' functionality.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Olivier Manches, Khemary Um, Anne Boudier, Yasmina Maddouri, Sarah Lyon-Caen, Sam Bayat, Remy Slama, Claire Philippat, Valerie Siroux, Laurence Chaperot
Summary: The study explores the relationship between maternal and neonatal immune function, specifically focusing on cytokine secretion. It found that pregnant women and neonates have distinct cytokine secretion profiles. Several factors, including pre-conception BMI and smoking, were associated with cytokine levels in both mothers and children. This research provides insights into fetal immune development and the factors influencing maternal-child immune interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pathology
Xiaoling Wan, Jieqiong Chen, Yidong Wu, Zhixuan Chen, Yin Liu, Tong Li, Junran Sun, Ting Zhang, Fuling Zhou, Xingxu Huang, Yang Li, Xinjie Wang, Xiaodong Sun
Summary: The study developed a Cas12a-based DNA detection platform for rapid, convenient, and sensitive diagnosis of Leber hereditary optic neuropathy (LHON) variants. The method can be completed within 30 minutes using only one drop of blood, and showed high consistency with Sanger sequencing and next-generation sequencing (NGS) in both specificity and sensitivity.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2023)
Article
Biology
Yafang Wang, Yang Liu, Yan Wang, Yidong Wu, Zhixuan Chen, Feng Wang, Xiaoling Wan, Fenghua Wang, Xiaodong Sun
Summary: Disordered immune responses and cholesterol metabolism are implicated in age-related macular degeneration (AMD), the leading cause of blindness in elderly individuals. In this study, researchers investigated the role and mechanism of SULT2B1 and STS enzymes in AMD. They found that SULT2B1 promoted M2 macrophage activation and cholesterol efflux, while STS inhibited M2 polarization through LXR-ABCA1/G1 signaling to protect against choroidal neovascularization.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biochemistry & Molecular Biology
Sheng-yuan Zhang, Qiu-ping Xu, Li-na Shi, Shih-wen Li, Wei-hong Wang, Qing-qing Wang, Liao-xun Lu, Hui Xiao, Jun-hong Wang, Feng-ying Li, Yin-ming Liang, Si-tang Gong, Hao-ran Peng, Zheng Zhang, Hong Tang
Summary: T lymphopenia, commonly seen in the early phase of sepsis, is associated with increased morbidity and mortality. We have discovered that CD4(+) T cells interact with macrophages through MHC II to inhibit TLR pro-inflammatory signaling, thereby regulating excessive inflammation. This finding may contribute to the development of preventive treatments for sepsis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cell Biology
Chenbo Ding, Zhibin Yu, Esen Sefik, Jing Zhou, Eleanna Kaffe, Gaoyang Wang, Bin Li, Richard A. Flavell, Weiguo Hu, Youqiong Ye, Hua-Bing Li
Summary: This study identified a T-reg-specific long noncoding RNA called Altre, which plays a role in regulating the mitochondrial function of T-reg cells in the liver of old mice by binding to Yin Yang 1. Deletion of Altre accelerates aging-associated liver pathogenesis.
Article
Immunology
Camille Niveau, Eleonora Sosa Cuevas, Benoit Roubinet, Mylene Pezet, Michel Thepaut, Stephane Mouret, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Philippe Saas, Caroline Aspord
Summary: Dendritic cell subsets play a crucial role in shaping anti-tumour immunity. The study found that melanoma tumour cells display aberrant glycan motifs which can be sensed by dendritic cells through specific receptors. This interaction may lead to abnormal immune responses. The study suggests that targeting the glycan/receptor axis could be a promising strategy for improving cancer immunotherapy.
Article
Oncology
Jamila Kacher, Olivier Manches, Caroline Aspord, Herve Sartelet, Laurence Chaperot
Summary: In MYCN-nonamplified neuroblastoma, CCL2 produced by neuroblastoma cells induces the recruitment of antigen-presenting cells (DCs and monocytes/macrophages), allowing infiltration by T cells, in link with CCL19 and CCL22 production, hence favoring immune responses.
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Eleonora Sosa Cuevas, Nathalie Bendriss-Vermare, Stephane Mouret, Florence De Fraipont, Julie Charles, Jenny Valladeau-Guilemond, Laurence Chaperot, Caroline Aspord
Summary: This study reveals, for the first time, the phenotypic and functional heterogeneity of plasmacytoid dendritic cells (pDCs) in melanoma patients, and their potential involvement in shaping clinical outcomes.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
