Article
Biochemistry & Molecular Biology
Meng Chen, Liying Shan, Ying Gan, Lijie Tian, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: MTSS1 plays a role in osteoblast differentiation and bone homeostasis by regulating Src-Wnt/beta-catenin signaling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ozgun Ozalp, Ozge Cark, Yagmur Azbazdar, Betul Haykir, Gokhan Cucun, Ismail Kucukaylak, Gozde Alkan-Yesilyurt, Erdinc Sezgin, Gunes Ozhan
Summary: Nradd, a negative regulator of Wnt/beta-catenin signaling, suppresses Wnt-mediated patterning in zebrafish embryos and mammalian cells, highlighting its role in regulating cell growth and development through modulating Wnt signaling and apoptosis.
Article
Cell & Tissue Engineering
Xiaoli Shi, Yunzhu Cen, Liying Shan, Lijie Tian, Endong Zhu, Hairui Yuan, Xiaoxia Li, Ying Liu, Baoli Wang
Summary: The study revealed that NDRG1 negatively regulated cell growth and modulated the differentiation of marrow stromal progenitor cells towards adipocytes, impacting the osteoblast differentiation. NDRG1 interacted with LRP6 and inactivated the canonical Wnt/beta-catenin signaling cascade in stromal progenitor cells. In vivo transfection of Ndrg1 siRNA prevented inactivation of Wnt signaling and improved osteoblasts reduction and fat accumulation in ovariectomized mice.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Yeong Chan Ryu, Jiyeon Park, You-Rin Kim, Sehee Choi, Geon-Uk Kim, Eunhwan Kim, Yumi Hwang, Heejene Kim, Gyoonhee Han, Soung-Hoon Lee, Kang-Yell Choi
Summary: The number of people suffering from hair loss is increasing, affecting not only older men but also women and young people. This study reveals that CXXC5 acts as a mediator for hair loss induced by prostaglandin D-2 (PGD(2)) through suppression of the Wnt/beta-catenin signaling pathway. CXXC5 inhibition or activation of the Wnt/beta-catenin pathway can restore hair loss caused by PGD(2) or overcome suppression of neogenic hair growth.
Article
Endocrinology & Metabolism
Bin-Feng Cheng, Xiao Feng, Yao-Xin Gao, Shao-Qin Jian, Shi-Rao Liu, Mian Wang, Yun-Fei Xie, Lei Wang, Zhi-Wei Feng, Hai-Jie Yang
Summary: NCAM regulates osteoblast differentiation through activation of the Wnt/β-catenin and PI3K-Akt signaling pathways, with its silencing inhibiting osteoblastic differentiation in various cell lines.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunok Oh, Chang-Bum Ahn, M. P. C. K. Marasinghe, Jae-Young Je
Summary: Chitosan, a naturally occurring biodegradable polymer, demonstrates osteogenic effects in murine bone marrow-derived mesenchymal stem cells. Grating gallic acid onto chitosan enhances its potential for osteogenesis. Mechanistic study shows that GAC activates the Wnt signaling pathway to promote osteoblast differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Eunhwan Kim, Seol Hwa Seo, Yumi Hwang, Yeong Chan Ryu, Heejene Kim, Kyoung-Mi Lee, Jin Woo Lee, Kwang Hwan Park, Kang-Yell Choi
Summary: Researchers have found that by inhibiting the function of CXXC5 protein and restoring the suppressed Wnt/β-catenin signaling, diabetic wound healing and angiogenesis can be accelerated in diabetic mice, providing a potential therapeutic approach for treating diabetic foot ulcers.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Cell & Tissue Engineering
Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang
Summary: The loss of NFIX gene affects endochondral ossification and mineralization in bone, with NFIX inducing osteoblast differentiation and impairing adipocyte formation by regulating HMGA1 expression. HMGA1 plays a role in osteoblast commitment and mediates NFIX function by activating canonical Wnt signaling pathways.
Article
Oncology
Seol Hwa Seo, Eunhwan Kim, Soung-Hoon Lee, Yong-Ho Lee, Dai Hoon Han, Hyesun Go, Je Kyung Seong, Kang-Yell Choi
Summary: The overexpression of CXXC5 and suppression of Wnt/β-catenin signaling in visceral adipose tissues of obesity-related diabetes patients have been identified. By interfering with the binding between CXXC5 and Dvl, the inhibition of CXXC5 function can restore the Wnt/β-catenin signaling and reverse metabolic abnormalities, providing a potential therapeutic strategy for obesity-related diabetes.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Hairui Yuan, Mengyue Li, Xue Feng, Endong Zhu, Baoli Wang
Summary: miR-142a-5p plays a critical role in osteoblast differentiation by targeting NFIA and being regulated by the Wnt/beta-catenin signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Morgane Le Rolle, Filippo Massa, Pam Siggers, Laurent Turchi, Agnes Loubat, Bon-Kyoung Koo, Hans Clevers, Andy Greenfield, Andreas Schedl, Marie-Christine Chaboissier, Anne-Amandine Chassot
Summary: This study shows that germ cell-intrinsic beta-catenin activity in mouse embryonic ovaries is essential for maintaining pluripotency and its repression is crucial for differentiation and meiosis entry. The interaction of beta-catenin with the pluripotent-associated factor POU5F1 in the nucleus is associated with germ cell pluripotency, and its exit from the nucleus correlates with germ cell differentiation. These findings highlight the role of beta-catenin as a central gatekeeper in ovarian differentiation and gametogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Faezeh Sahebdel, Azita Parvaneh Tafreshi, Ehsan Arefian, Eleni Roussa, Samad Nadri, Bahman Zeynali
Summary: The study found that trabecular meshwork-derived mesenchymal stem cells (TM-MSCs) have higher neurogenic differentiation potential compared to adipose tissue-derived mesenchymal stem cells (AD-MSCs) and bone marrow-derived stem cells (BMSCs). The activation of the Wnt/beta-catenin pathway directs the neurally induced TM-MSCs towards a dopaminergic fate.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yinan Hu, Qi Wang, Jun Yu, Qing Zhou, Yanhan Deng, Juan Liu, Lei Zhang, Yongjian Xu, Weining Xiong, Yi Wang
Summary: This study reveals the involvement of ACP5 in the initiation and progression of pulmonary fibrosis. Acp5 deficiency protects mice from lung injury and fibrosis, and the upregulation of Acp5 by TGF-beta 1 enhances β-catenin signaling, promoting fibroblast differentiation, proliferation, and migration. Furthermore, treatment with Acp5 siRNA or inhibitor can reverse established lung fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Irina Giralt, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Guillem Pons, Ainara Magdaleno, Miguel F. Segura, Constantino Sabado, Raquel Hladun, Diego Arango, Jose Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: The study demonstrates the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, resulting in beta-catenin activation and modulation of focal adhesion kinase, with positive effects on myogenic marker expression and a reduction in proliferation and invasion. In addition, the chemical inhibitor WAY-262611 was able to impair tumor cell survival in vivo, suggesting DKK-1 as a potential molecular target for novel therapeutic strategies in RMS patients, especially those with high DKK-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Ruhi Gulati, Michael Johnston, Maria Rivas, Ashley Cast, Meenasri Kumbaji, Margaret A. Hanlon, Sanghoon Lee, Ping Zhou, Charissa Lake, Emily Schepers, Kyung-Won Min, Je-Hyun Yoon, Rebekah Karns, Lola M. Reid, Dolores Lopez-Terrada, Lubov Timchenko, Sreeja Parameswaran, Matthew T. Weirauch, Sarangarajan Ranganathan, Alexander Bondoc, James Geller, Gregory Tiao, Soona Shin, Nikolai Timchenko
Summary: This study investigates the development mechanism of fibrolamellar hepatocellular carcinoma (FLC) and identifies the role of cancer-enhancing genomic regions or aggressive liver cancer domains (CEGRs/ALCDs). It finds that beta-catenin is the driver of FLC and inhibiting beta-catenin can prevent the development of FLC.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Cell Biology
Seung-Jun Lee, Ka-Hwa Kim, Dong-Joon Lee, Pyunggang Kim, Jinah Park, Seong-Jin Kim, Han-Sung Jung
Summary: Spermatogonial stem cell (SSC) self-renewal is regulated by reciprocal interactions between Sertoli cells and SSCs in the testis. The study focused on the mechanism by which MAST4 in Sertoli cells transmits the signal and regulates SSCs, especially cell cycle regulation. The results demonstrate that MAST4 plays a pivotal role in maintaining the cell cycle of SSCs via the CDK2-PLZF interaction.
CELL PROLIFERATION
(2023)
Article
Endocrinology & Metabolism
K. J. Kim, N. Hong, S. Lee, S. Shin, Y. Rhee
Summary: Hajdu-Cheney syndrome (HCS) is a rare inherited skeletal disorder caused by mutations in the NOTCH2 gene. Current treatment options for HCS are limited, and previous reports have shown limited efficacy with other medications. This case report presents the first evidence of romosozumab treatment for HCS in Korea, showing significant improvements in bone mineral density and reduced markers of bone turnover. These findings suggest that romosozumab may be a promising treatment option for HCS patients with osteoporosis.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Jin Ryu, Sujeong Eom, Hyeon Chang Kim, Chang Oh Kim, Yumie Rhee, Seng Chan You, Namki Hong
Summary: This study aimed to develop a deep learning model based on chest X-rays to predict the presence of sarcopenia. The results showed that the model performed well in predicting muscle parameters and sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Seung Won Burm, Hyeon Chang Kim, Chang Oh Kim, Yumie Rhee
Summary: Low countermovement jump power is associated with prevalent fracture, osteoporosis, and sarcopenia in older adults. However, whether jump power predicts incident fracture risk remains uninvestigated. This study found that low jump power is associated with a higher risk of fracture in older adults and can predict fracture risk independently of sarcopenia and osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Sang Wouk Cho, Sungjae Shin, Seunghyun Lee, Seol A. Jang, Seunghyun Roh, Young Han Lee, Yumie Rhee, Steven R. R. Cummings, Hwiyoung Kim, Kyoung Min Kim
Summary: By using deep learning methods on lateral spine radiography, osteoporosis and vertebral fractures can be better diagnosed, leading to improved referral of high-risk individuals to bone-density testing.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
E. -j. Kim, H. -y. Kim, L. Li, Q. Tang, K. -h. Kim, H. Ohshima, H. -s. Jung
Summary: The enamel knot (EK) is a cluster of nondividing epithelial cells that acts as a signaling center in tooth germs. This study analyzed the cellular mechanisms in the EK related to bone morphogenetic protein (Bmp) and compared two species with different cuspal patterning. The findings suggest that the cellular mechanisms in the EK, such as cell proliferation and apoptosis, are associated with Bmp4 and play a crucial role in tooth morphogenesis.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jong-Min Lee, Tae-Yang Lim, Sang-Bin Oh, Seung-Jun Lee, Yun Soo Bae, Han-Sung Jung
Summary: The localization of Ahnak gene is abnormal in the kidney and ureter, which is associated with the imbalance of calcium homeostasis, leading to nonobstructive hydronephrosis. Ahnak plays a crucial role in the development of the kidney and ureter, and in maintaining the function of the urinary system.
CELL AND BIOSCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ahmed Elhakim, Sunil Kim, Su-Jung Shin, Han-Sung Jung, Euiseong Kim
Summary: In this study, the authors investigated the effect of icariin on reducing root resorption and promoting functional healing of denuded roots in a rat model of tooth replantation. The results showed that icariin had a dose-dependent inhibitory effect on the differentiation of osteoclasts and enhanced osteogenic activity in stem cells. Micro-CT imaging and histological analysis confirmed the effectiveness of icariin in reducing root resorption and improving tooth retention and survival.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Jung Ho Kim, Graham Treece, Hyeon Chang Kim, Jun Yong Choi, Yumie Rhee
Summary: Middle-aged men living with human immunodeficiency virus (MLWH) have a significantly higher risk of hip fracture, almost a decade earlier than those without infection. Limited data on cortical and trabecular bone deficit in MLWH were observed. This study found that MLWH had lower hip bone density and deficits in certain bone parameters compared to age and body mass index-matched controls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Sungjae Shin, Seunghyun Lee, Yumie Rhee
Summary: This study found that romosozumab may be more effective in improving trabecular bone score compared to denosumab therapy in postmenopausal women who have previously received antiresorptive agents. Notably, romosozumab treatment resulted in similar improvement in trabecular bone score in patients previously treated with antiresorptive agents compared to drug-naive patients.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Seung-Rok Kim, Ey-In Lee, Yongnyun Kim, Sang Wouk Cho, Namki Hong, Yumie Rhee, Jin-Woo Park
Summary: This study presents a new jumping-power assessment tool in a preclinical rodent model to study sarcopenia. The device utilizes electrical stimulation and load cell to capture the jumping data of mice, and has various potential utilities.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Namki Hong, Kyoung Jin Kim, Min Heui Yu, Seong Ho Jeong, Seunghyun Lee, Jung Soo Lim, Yumie Rhee
Summary: This study examined the risk of dementia in patients with primary aldosteronism (PA) compared to patients with essential hypertension (EH). The findings revealed that treated PA patients were more likely to develop all-cause dementia compared to EH patients. Among PA patients, those using mineralocorticoid receptor antagonists (MRA) had a higher risk, especially for vascular dementia.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Endocrinology & Metabolism
Kyoung Jin Kim, Ji Eun Song, Ji Hyun Kim, Namki Hong, Sin Gon Kim, Juneyoung Lee, Yumie Rhee
Summary: This study investigated the prevalence and long-term health outcomes of chronic idiopathic hypophosphatemia (CIH) patients in South Korea. The results showed that CIH patients had a higher risk of various complications, including cardiovascular outcomes and chronic kidney disease. The study also found higher risks of mortality and hospitalization among CIH patients compared to the control group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Ka-Hwa Kim, Eun-Jung Kim, Hyun-Yi Kim, Shujin Li, Han-Sung Jung
Summary: Tooth development relies on the interactions between dental epithelium and dental mesenchyme. In this study, hiPSC-derived human ameloblast organoids (hAOs) were cultured using a 3D system. hAOs exhibited similar properties to ameloblasts and showed enamel formation in response to calcium and mineralization in interaction with dental mesenchyme. Additionally, hAOs showed osteogenic and odontogenic differentiation potential and demonstrated tooth regenerative potential in interaction with mouse dental mesenchyme. This research provides insights into hiPSC-derived dental source and highlights the potential of hAOs for tooth regeneration and study of dental diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anish Ashok Adpaikar, Jong-Min Lee, Dong-Joon Lee, Hye-Yeon Cho, Hayato Ohshima, Seok Jun Moon, Han-Sung Jung
Summary: Taste receptor cells can dedifferentiate and acquire stem/progenitor cell-like states after nerve injury, leading to enhanced taste bud regeneration. This finding suggests that differentiated taste receptor cells have the potential to enter the cell cycle and contribute to taste bud renewal. These dedifferentiated cells, along with resident stem/progenitor cells, play a crucial role in the regeneration of taste buds following nerve injury.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
