Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine

Intrauterine growth-restricted sheep fetuses exhibit smaller hindlimb muscle fibers and lower proportions of insulin-sensitive Type I fibers near term

(2016) Dustin T. Yates et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction

(2016) Antoni R. Macko et al.   ENDOCRINOLOGY

Re-Evaluating “Transitional Neonatal Hypoglycemia”: Mechanism and Implications for Management

(2015) Charles A. Stanley et al.   JOURNAL OF PEDIATRICS

Fetal Adrenal Demedullation Lowers Circulating Norepinephrine and Attenuates Growth Restriction but not Reduction of Endocrine Cell Mass in an Ovine Model of Intrauterine Growth Restriction

(2015) Melissa Davis et al.   Nutrients

Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep

(2014) Paul J. Rozance et al.   DIABETES

Ischemic placental disease and risks of perinatal mortality and morbidity and neurodevelopmental outcomes

(2014) Cande V. Ananth et al.   SEMINARS IN PERINATOLOGY

Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency

(2013) Sean W. Limesand et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep

(2013) Xiaochuan Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation

(2013) A. R. Macko et al.   Journal of Developmental Origins of Health and Disease

Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins

(2012) Susanne G. Straub et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

Leucine Stimulates Insulin Secretion via Down-regulation of Surface Expression of Adrenergic α2A Receptor through the mTOR (Mammalian Target of Rapamycin) Pathway

(2012) Jun Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep

(2012) Dustin T. Yates et al.   JOURNAL OF PHYSIOLOGY-LONDON

Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus

(2011) Alice S. Green et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

UCP2 mRNA expression is dependent on glucose metabolism in pancreatic islets

(2011) Louise T. Dalgaard   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

(2011) Christine A. Robson-Doucette et al.   DIABETES

Chronic pulsatile hyperglycemia reduces insulin secretion and increases accumulation of reactive oxygen species in fetal sheep islets

(2011) Alice S Green et al.   JOURNAL OF ENDOCRINOLOGY

Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction

(2010) Rafael A. Leos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Describing hypoglycemia — Definition or operational threshold?

(2010) Paul J. Rozance et al.   EARLY HUMAN DEVELOPMENT

β2-Adrenergic receptor desensitization in perirenal adipose tissue in fetuses and lambs with placental insufficiency-induced intrauterine growth restriction

(2010) Xiaochuan Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

One process for pancreatic β-cell coalescence into islets involves an epithelial–mesenchymal transition

(2009) Lori Cole et al.   JOURNAL OF ENDOCRINOLOGY

Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

(2009) A. H. Rosengren et al.   SCIENCE

Clearance of store-released Ca2+ by the Na+-Ca2+ exchanger is diminished in aortic smooth muscle from Na+-K+-ATPase α2-isoform gene-ablated mice

(2008) Ronald M. Lynch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

(2007) Charles Affourtit et al.   BIOCHEMICAL JOURNAL

Reduced blood glucose levels, increased insulin levels and improved glucose tolerance in α2A-adrenoceptor knockout mice

(2007) Eriika Savontaus et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

α2-Adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice

(2006) E Moura et al.   BRITISH JOURNAL OF PHARMACOLOGY