Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis
Authors
Keywords
-
Journal
PLoS One
Volume 11, Issue 5, Pages e0152869
Publisher
Public Library of Science (PLoS)
Online
2016-05-04
DOI
10.1371/journal.pone.0152869
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Modeling of Glucose-Induced cAMP Oscillations in Pancreatic β Cells: cAMP Rocks when Metabolism Rolls
- (2015) Bradford E. Peercy et al. BIOPHYSICAL JOURNAL
- Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A
- (2015) Sindhu Rajan et al. Molecular Metabolism
- Recent developments in the discovery of FFA1 receptor agonists as novel oral treatment for type 2 diabetes mellitus
- (2014) Elisabeth Defossa et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40
- (2014) Jing Qian et al. CELLULAR SIGNALLING
- Gαq signalling: The new and the old
- (2014) Guzmán Sánchez-Fernández et al. CELLULAR SIGNALLING
- Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet
- (2014) J. Molina et al. DIABETES
- Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists
- (2014) Ryutaro Nakashima et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A Naturally Occurring GIP Receptor Variant Undergoes Enhanced Agonist-Induced Desensitization, Which Impairs GIP Control of Adipose Insulin Sensitivity
- (2014) S. Mohammad et al. MOLECULAR AND CELLULAR BIOLOGY
- Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics
- (2014) Richard K.P. Benninger et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients
- (2014) Venkategowda Sunil et al. BMC Pharmacology & Toxicology
- Extracellular calcium influx activates adenylate cyclase 1 and potentiates insulin secretion in MIN6 cells
- (2013) Tetsuya Kitaguchi et al. BIOCHEMICAL JOURNAL
- Metabolic Signaling in Fuel-Induced Insulin Secretion
- (2013) Marc Prentki et al. Cell Metabolism
- The Anx7(+/-) Knockout Mutation Alters Electrical and Secretory Responses to Ca2+-Mobilizing Agents in Pancreatic �-cells
- (2013) David Mears et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls
- (2013) D. J. Drucker DIABETES
- Secretion of Glucose-Dependent Insulinotropic Polypeptide in Patients With Type 2 Diabetes: Systematic review and meta-analysis of clinical studies
- (2013) S. Calanna et al. DIABETES CARE
- Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics
- (2013) Andreja Jovic et al. Integrative Biology
- Chronic activation of a designer Gq-coupled receptor improves β cell function
- (2013) Shalini Jain et al. JOURNAL OF CLINICAL INVESTIGATION
- Quantitative properties and receptor reserve of the DAG and PKC branch of Gq-coupled receptor signaling
- (2013) Björn H. Falkenburger et al. JOURNAL OF GENERAL PHYSIOLOGY
- Minireview: Novel Aspects of M3Muscarinic Receptor Signaling in Pancreatic β-Cells
- (2013) Kenichiro Nakajima et al. MOLECULAR ENDOCRINOLOGY
- KATP channels and islet hormone secretion: new insights and controversies
- (2013) Frances M. Ashcroft et al. Nature Reviews Endocrinology
- An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans
- (2013) Stefan Amisten et al. PHARMACOLOGY & THERAPEUTICS
- Molecular properties of muscarinic acetylcholine receptors
- (2013) Tatsuya HAGA PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?
- (2013) Arturo D. Mancini et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Ion channels and regulation of insulin secretion in human β-cells
- (2013) Leonid E. Fridlyand et al. Islets
- Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins
- (2012) Susanne G. Straub et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion
- (2012) Sindhu Rajan et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Role of phospholipase Cε in physiological phosphoinositide signaling networks
- (2012) Alan V. Smrcka et al. CELLULAR SIGNALLING
- GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence
- (2012) A. R. Meloni et al. DIABETES OBESITY & METABOLISM
- Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes
- (2012) Z. F. Kang et al. DIABETOLOGIA
- The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice
- (2012) S. Vollert et al. DIABETOLOGIA
- G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
- (2012) M. Ferdaoussi et al. DIABETOLOGIA
- The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function
- (2012) X. Q. Dai et al. DIABETOLOGIA
- Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor
- (2012) Francis S. Willard et al. Experimental Diabetes Research
- Regulation of voltage-gated potassium channels by PI(4,5)P2
- (2012) Martin Kruse et al. JOURNAL OF GENERAL PHYSIOLOGY
- TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial
- (2012) Charles F Burant et al. LANCET
- Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling
- (2012) Domitille Heitzler et al. Molecular Systems Biology
- Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization
- (2012) Gina M. Whitaker et al. PLoS One
- Evidence That Ca2+ within the Microdomain of the L-Type Voltage Gated Ca2+ Channel Activates ERK in MIN6 Cells in Response to Glucagon-Like Peptide-1
- (2012) Joanne Selway et al. PLoS One
- Allosteric Modulation of the Activity of the Glucagon-like Peptide-1 (GLP-1) Metabolite GLP-1 9–36 Amide at the GLP-1 Receptor
- (2012) Naichang Li et al. PLoS One
- Cyclic AMP dynamics in the pancreatic β-cell
- (2012) Anders Tengholm UPSALA JOURNAL OF MEDICAL SCIENCES
- The virtual liver: a multidisciplinary, multilevel challenge for systems biology
- (2012) Hermann-Georg Holzhütter et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats
- (2012) Mohammed Seed Ahmed et al. Islets
- Molecular mechanisms of muscarinic acetylcholine receptor–stimulated increase in cytosolic free Ca2+ concentration and ERK1/2 activation in the MIN6 pancreatic β-cell line
- (2011) Joanne L. Selway et al. ACTA DIABETOLOGICA
- Systems analysis of GLP-1 receptor signaling in pancreatic β-cells
- (2011) Yukari Takeda et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics
- (2011) Nicolai M. Doliba et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- α2-Adrenoceptor Regulation of Blood Glucose Homeostasis
- (2011) Veronica Fagerholm et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Regulation of calcium in pancreatic α- and β-cells in health and disease
- (2011) Patrik Rorsman et al. CELL CALCIUM
- Mechanism of Activation and Inactivation of Gq/Phospholipase C-β Signaling Nodes
- (2011) T. Kendall Harden et al. CHEMICAL REVIEWS
- From PDE3B to the regulation of energy homeostasis
- (2011) Eva Degerman et al. CURRENT OPINION IN PHARMACOLOGY
- Mechanisms of Control of the Free Ca2+ Concentration in the Endoplasmic Reticulum of Mouse Pancreatic -Cells: Interplay With Cell Metabolism and [Ca2+]c and Role of SERCA2b and SERCA3
- (2011) M. A. Ravier et al. DIABETES
- Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells
- (2011) Roberta Fiume et al. FASEB JOURNAL
- Dynamics of insulin secretion and the clinical implications for obesity and diabetes
- (2011) Susumu Seino et al. JOURNAL OF CLINICAL INVESTIGATION
- Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice
- (2011) Benjamin J. Lamont et al. JOURNAL OF CLINICAL INVESTIGATION
- Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?
- (2011) N M Whalley et al. JOURNAL OF ENDOCRINOLOGY
- Subtype Differences in Pre-Coupling of Muscarinic Acetylcholine Receptors
- (2011) Jan Jakubík et al. PLoS One
- Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: A computational analysis
- (2011) Leonid E. Fridlyand et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Mathematical modeling and statistical analysis of calcium-regulated insulin granule exocytosis in β-cells from mice and humans
- (2011) Morten Gram Pedersen et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Two incretin hormones GLP-1 and GIP: Comparison of their actions in insulin secretion and β cell preservation
- (2011) Daisuke Yabe et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans
- (2011) Patrik Rorsman et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Bursting and calcium oscillations in pancreatic β-cells: specific pacemakers for specific mechanisms
- (2010) L. E. Fridlyand et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets
- (2010) Nicolai M. Doliba et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors
- (2010) Nicole Ziegler et al. BIOORGANIC & MEDICINAL CHEMISTRY
- How Pancreatic β-Cells Discriminate Long and Short Timescale cAMP Signals
- (2010) Bradford E. Peercy et al. BIOPHYSICAL JOURNAL
- Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells
- (2010) B. Roger et al. DIABETOLOGIA
- Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?
- (2010) M. A. Nauck et al. DIABETOLOGIA
- Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated -cells
- (2010) A. Wuttke et al. JOURNAL OF CELL SCIENCE
- The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice
- (2010) Antonia Sassmann et al. JOURNAL OF CLINICAL INVESTIGATION
- Kinetics of M1muscarinic receptor and G protein signaling to phospholipase C in living cells
- (2010) Björn H. Falkenburger et al. JOURNAL OF GENERAL PHYSIOLOGY
- Kinetics of PIP2metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells
- (2010) Björn H. Falkenburger et al. JOURNAL OF GENERAL PHYSIOLOGY
- Physiologic Implications of Phosphoinositides and Phospholipase C in the Regulation of Insulin Secretion
- (2010) Hanae YAMAZAKI et al. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
- Theme and variations on kinetics of GPCR activation/deactivation
- (2010) Jean-Pierre Vilardaga JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Dissociated effects of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide–1 on β-cell secretion and insulin clearance in mice
- (2010) Giovanni Pacini et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Channelopathies linked to plasma membrane phosphoinositides
- (2010) Diomedes E. Logothetis et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Expression and Regulation of Cyclic Nucleotide Phosphodiesterases in Human and Rat Pancreatic Islets
- (2010) Emilia Heimann et al. PLoS One
- M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1
- (2010) K. C. Kong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glucose sensing in the pancreatic beta cell: a computational systems analysis
- (2010) Leonid E Fridlyand et al. Theoretical Biology and Medical Modelling
- Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications
- (2010) Inigo Ruiz de Azua et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Postsynaptic Signal Transduction Models for Long-Term Potentiation and Depression
- (2010) Tiina Manninen et al. Frontiers in Computational Neuroscience
- Temporal Sensitivity of Protein Kinase A Activation in Late-Phase Long Term Potentiation
- (2010) MyungSook Kim et al. PLoS Computational Biology
- A Model of Action Potentials and Fast Ca2+ Dynamics in Pancreatic β-Cells
- (2009) L.E. Fridlyand et al. BIOPHYSICAL JOURNAL
- Overexpression of GPR40 in Pancreatic -Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice
- (2009) K. Nagasumi et al. DIABETES
- Roles of cAMP signalling in insulin granule exocytosis
- (2009) S. Seino et al. DIABETES OBESITY & METABOLISM
- Cell-cell interactions in the endocrine pancreas
- (2009) R. Jain et al. DIABETES OBESITY & METABOLISM
- Regulation of insulin secretion: a matter of phase control and amplitude modulation
- (2009) J. C. Henquin DIABETOLOGIA
- The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β-cell line
- (2009) Leigh Anne Swayne et al. EMBO REPORTS
- NALCN: a regulated leak channel
- (2009) Patrick Gilon et al. EMBO REPORTS
- Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
- (2009) Luan Shu et al. HUMAN MOLECULAR GENETICS
- Capacitative calcium entry: from concept to molecules
- (2009) James W. Putney IMMUNOLOGICAL REVIEWS
- Mechanism of Epac Activation
- (2009) Tamara Tsalkova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity
- (2009) P. J. Woodroffe et al. JOURNAL OF MATHEMATICAL BIOLOGY
- Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
- (2009) Bo Ahrén NATURE REVIEWS DRUG DISCOVERY
- A chemical-genetic approach to study G protein regulation of β cell function in vivo
- (2009) Jean-Marc Guettier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes
- (2009) A. H. Rosengren et al. SCIENCE
- Cephalic phase insulin release in healthy humans after taste stimulation?
- (2008) Tino Just et al. APPETITE
- Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation
- (2008) Veerle Vanderheyden et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Inositol trisphosphate and calcium signalling mechanisms
- (2008) Michael J. Berridge BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting β-cells
- (2008) Natalia A. Tamarina et al. CELL CALCIUM
- Modelling the dynamics of signalling pathways
- (2008) Sree N. Sreenath et al. Essays in Biochemistry
- Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas
- (2008) Ditte Tornehave et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: Can a single model explain disparate results?
- (2008) Christopher J. Brinkerhoff et al. JOURNAL OF THEORETICAL BIOLOGY
- Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
- (2008) Riina M. Luik et al. NATURE
- Coupling mode of receptors and G proteins
- (2008) Peter Hein et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Diminished Phosphodiesterase-8B Potentiates Biphasic Insulin Response to Glucose
- (2007) Avital Dov et al. ENDOCRINOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started