RNA Sequencing Exposes Adaptive and Immune Responses to Intrauterine Growth Restriction in Fetal Sheep Islets

Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep

(2016) William W. Hay et al.   ACTA PAEDIATRICA

Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction

(2016) Antoni R. Macko et al.   ENDOCRINOLOGY

Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine

(2016) Xiaochuan Chen et al.   JOURNAL OF ENDOCRINOLOGY

The pancreas anatomy conditions the origin and properties of resident macrophages

(2015) Boris Calderon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex

(2015) Eileen I. Chang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fetal Adrenal Demedullation Lowers Circulating Norepinephrine and Attenuates Growth Restriction but not Reduction of Endocrine Cell Mass in an Ovine Model of Intrauterine Growth Restriction

(2015) Melissa Davis et al.   Nutrients

Neutralizing Th2 Inflammation in Neonatal Islets Prevents β-Cell Failure in Adult IUGR Rats

(2014) Lane J. Jaeckle Santos et al.   DIABETES

Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep

(2014) Paul J. Rozance et al.   DIABETES

SGA Children with Moderate Catch-Up Growth Are Showing the Impaired Insulin Secretion at the Age of 4

(2014) Ivana Milovanovic et al.   PLoS One

UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

(2014) A. Vozza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency

(2013) Sean W. Limesand et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep

(2013) Xiaochuan Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice

(2013) Aaron R Cox et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes

(2013) Taiki Tsutsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syntaxin 16 is a master recruitment factor for cytokinesis

(2013) Hélia Neto et al.   MOLECULAR BIOLOGY OF THE CELL

Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation

(2013) A. R. Macko et al.   Journal of Developmental Origins of Health and Disease

Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity

(2012) Lara Bonomi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Developmental origins of diabetes: The role of oxidative stress

(2012) Rebecca A. Simmons   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Trefoil Factor 2 Promotes Cell Proliferation in Pancreatic β-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation

(2012) Kazuki Orime et al.   ENDOCRINOLOGY

Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas

(2012) Xiaochuan Chen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Intrauterine Growth Restriction and the Innate Immune System in Preterm Infants of =32 Weeks Gestation

(2012) Birte Tröger et al.   Neonatology

Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus

(2011) Alice S. Green et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction

(2010) Rafael A. Leos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation

(2010) S. H. Huang et al.   DIABETOLOGIA

Consequences of a compromised intrauterine environment on islet function

(2010) Alice S Green et al.   JOURNAL OF ENDOCRINOLOGY

Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia

(2010) Miğraci Tosun et al.   Journal of Maternal-Fetal & Neonatal Medicine

Transcriptional Control of Mitochondrial Biogenesis and Function

(2009) M. Benjamin Hock et al.   Annual Review of Physiology

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic β-cells

(2008) Catherine Arden et al.   BIOCHEMICAL JOURNAL

On the origin of the   cell

(2008) J. M. Oliver-Krasinski et al.   GENES & DEVELOPMENT