Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

(2017) Bo Xiao et al.   MOLECULAR THERAPY

Current and emerging therapeutic targets for IBD

(2017) Markus F. Neurath   Nature Reviews Gastroenterology & Hepatology

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

(2016) Mingzhen Zhang et al.   BIOMATERIALS

A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells

(2016) Mingzhen Zhang et al.   CANCER RESEARCH

Self assembled hyaluronic acid nanoparticles as a potential carrier for targeting the inflamed intestinal mucosa

(2016) Seyed Yaser Vafaei et al.   CARBOHYDRATE POLYMERS

Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages

(2016) Mariam Mohammadi et al.   JOURNAL OF CONTROLLED RELEASE

Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles ameliorates intestinal inflammation in vivo

(2016) Annika Frede et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

(2016) Abhijit A. Date et al.   JOURNAL OF CONTROLLED RELEASE

Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling

(2016) Katja Zschiebsch et al.   Journal of Crohns & Colitis

The ginger component 6-shogaol prevents TNF-α-induced barrier loss via inhibition of PI3K/Akt and NF-κB signaling

(2016) Julia Luettig et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy

(2016) Mingzhen Zhang et al.   MOLECULAR THERAPY

Do ginger-derived nanoparticles represent an attractive treatment strategy for inflammatory bowel diseases?

(2016) Mingzhen Zhang et al.   Nanomedicine

6-Shogaol, an active compound of ginger, alleviates allergic dermatitis-like skin lesions via cytokine inhibition by activating the Nrf2 pathway

(2016) Gunhyuk Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation

(2016) Bo Xiao et al.   Theranostics

Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases

(2016) Young-Su Yi   Immune Network

An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease

(2015) Zhen Huang et al.   BIOMATERIALS

Polymeric nanoparticle drug delivery technologies for oral delivery applications

(2015) Eric M Pridgen et al.   Expert Opinion on Drug Delivery

Extraintestinal Manifestations of Inflammatory Bowel Disease

(2015) Stephan R. Vavricka et al.   INFLAMMATORY BOWEL DISEASES

Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue

(2015) Susan Hua et al.   Nanomedicine-Nanotechnology Biology and Medicine

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Budesonide Loaded PLGA Nanoparticles for Targeting the Inflamed Intestinal Mucosa—Pharmaceutical Characterization and Fluorescence Imaging

(2015) Hussain Ali et al.   PHARMACEUTICAL RESEARCH

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

(2015) Sufeng Zhang et al.   Science Translational Medicine

Robust ICG Theranostic Nanoparticles for Folate Targeted Cancer Imaging and Highly Effective Photothermal Therapy

(2014) Mingbin Zheng et al.   ACS Applied Materials & Interfaces

Treatment of IBD: Where We Are and Where We Are Going

(2014) Charles N Bernstein   AMERICAN JOURNAL OF GASTROENTEROLOGY

Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract

(2014) Sushma R. Gundala et al.   CARCINOGENESIS

Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo

(2014) Huadong Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nanoparticles With Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice

(2014) Bo Xiao et al.   GASTROENTEROLOGY

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles

(2014) Jingyao Mu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticles

(2014) Bo Xiao et al.   Journal of Materials Chemistry B

Drug delivery strategies in the therapy of inflammatory bowel disease

(2013) Christian Lautenschläger et al.   ADVANCED DRUG DELIVERY REVIEWS

Multi-compartmental oral delivery systems for nucleic acid therapy in the gastrointestinal tract

(2012) Christina Kriegel et al.   ADVANCED DRUG DELIVERY REVIEWS

Dietary and commensal derived nutrients: shaping mucosal and systemic immunity

(2012) Sean P Spencer et al.   CURRENT OPINION IN IMMUNOLOGY

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin

(2012) Feng Li et al.   FOOD CHEMISTRY

Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa

(2012) Eva-Maria Collnot et al.   JOURNAL OF CONTROLLED RELEASE

Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation

(2012) Benoit Chassaing et al.   PLoS One

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Anti-inflammatory effects of [6]-shogaol: Potential roles of HDAC inhibition and HSP70 induction

(2011) Sehwan Shim et al.   FOOD AND CHEMICAL TOXICOLOGY

PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells

(2011) Jian Feng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Functional TNFα gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon

(2010) Hamed Laroui et al.   BIOMATERIALS

Interfacial Activity Assisted Surface Functionalization: A Novel Approach To Incorporate Maleimide Functional Groups and cRGD Peptide on Polymeric Nanoparticles for Targeted Drug Delivery

(2010) Udaya S. Toti et al.   MOLECULAR PHARMACEUTICS

pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model

(2009) Abdallah Makhlof et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model

(2009) Hamed Laroui et al.   GASTROENTEROLOGY

Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases

(2009) W. Ulbrich et al.   Journal of the Royal Society Interface

(−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells

(2008) Hye-Kyung Na et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis

(2008) Brice Moulari et al.   BIOMATERIALS

Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery

(2008) Yogesh B. Patil et al.   BIOMATERIALS

Pharmacokinetics of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol and Conjugate Metabolites in Healthy Human Subjects

(2008) S. M. Zick et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Antioxidant and tyrosinase inhibition properties of leaves and rhizomes of ginger species

(2008) E.W.C. Chan et al.   FOOD CHEMISTRY

Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer

(2008) Robert S. Chapkin et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages

(2008) Min-Hsiung Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL