Humanized mice: A brief overview on their diverse applications in biomedical research

A humanized mouse model of anaphylactic peanut allergy

(2017) Oliver T. Burton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice

(2017) Rashida Ginwala et al.   Journal of Neuroimmune Pharmacology

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

(2017) Ira Espuny-Camacho et al.   NEURON

Humanized mice in infectious diseases

(2016) W. Ernst   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

In vivo platforms for analysis of HIV persistence and eradication

(2016) J. Victor Garcia   JOURNAL OF CLINICAL INVESTIGATION

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation

(2016) Lena Allweiss et al.   JOURNAL OF HEPATOLOGY

A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

(2016) Andreas Reinisch et al.   NATURE MEDICINE

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

(2016) C.-L. Lu et al.   SCIENCE

Arginase-1–dependent promotion of T H 17 differentiation and disease progression by MDSCs in systemic lupus erythematosus

(2016) Hao Wu et al.   Science Translational Medicine

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3

(2015) Jeremy A. Goettel et al.   BLOOD

Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm

(2015) Gregory L. Szot et al.   Cell Stem Cell

A chimeric human–mouse model of Sjögren's syndrome

(2015) Nicholas A. Young et al.   CLINICAL IMMUNOLOGY

Humanized hemato-lymphoid system mice

(2015) A. P. A. Theocharides et al.   HAEMATOLOGICA

Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases

(2015) Iurii Koboziev et al.   INFLAMMATORY BOWEL DISEASES

Activated glycoprotein A repetitions predominant (GARP)–expressing regulatory T cells inhibit allergen-induced intestinal inflammation in humanized mice

(2015) Melanie Eschborn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection

(2015) Katja Giersch et al.   JOURNAL OF HEPATOLOGY

Humanized Mouse Model of Ebola Virus Disease Mimics the Immune Responses in Human Disease

(2015) Brian H. Bird et al.   JOURNAL OF INFECTIOUS DISEASES

Humanized Mice in Dermatology Research

(2015) Russell L. Griffin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice

(2015) Valérie Soulard et al.   Nature Communications

Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model

(2015) Beatrice Bissig-Choisat et al.   Nature Communications

Humanized mouse models of human cytomegalovirus infection

(2015) Lindsey B Crawford et al.   Current Opinion in Virology

Humanized hemato-lymphoid system mice

(2015) A. P. A. Theocharides et al.   HAEMATOLOGICA

HCV infection-associated hepatocellular carcinoma in humanized mice

(2015) Zhao Wang et al.   Infectious Agents and Cancer

Nonirradiated NOD,B6.SCID Il2rγ−/− KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

(2015) Brian E. McIntosh et al.   Stem Cell Reports

Role for early-differentiated natural killer cells in infectious mononucleosis

(2014) T. Azzi et al.   BLOOD

A Humanized Mouse Model of Autoimmune Insulitis

(2014) Ashley A. Viehmann Milam et al.   DIABETES

Human glial chimeric mice reveal astrocytic dependence of JC virus infection

(2014) Yoichi Kondo et al.   JOURNAL OF CLINICAL INVESTIGATION

Engrafted human stem cell–derived hepatocytes establish an infectious HCV murine model

(2014) Arnaud Carpentier et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34+ Stem Cells-Reconstituted NOD-scid IL2rγnull Mice

(2014) Fang Xiao et al.   PLoS One

Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection

(2014) L.-X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly neutralizing antibodies abrogate established hepatitis C virus infection

(2014) Y. P. de Jong et al.   Science Translational Medicine

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

(2014) Moses T. Bility et al.   PLoS Pathogens

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells

(2014) Panagiotis Douvaras et al.   Stem Cell Reports

An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity

(2013) K. Tezuka et al.   BLOOD

Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination

(2013) Su Wang et al.   Cell Stem Cell

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

Enabling Autologous Human Liver Regeneration with Differentiated Adipocyte Stem Cells

(2013) Dan Xu et al.   CELL TRANSPLANTATION

Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rγnullmice engrafted with human peripheral blood mononuclear cells

(2013) T. Nolte et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Humanized Mice, a New Model To Study the Influence of Drug Treatment on Neonatal Sepsis

(2013) Wolfgang Ernst et al.   INFECTION AND IMMUNITY

Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice

(2013) R. Ito et al.   JOURNAL OF IMMUNOLOGY

Subclinical CNS Inflammation as Response to a Myelin Antigen in Humanized Mice

(2013) Morad Zayoud et al.   Journal of Neuroimmune Pharmacology

Detection of JC Virus-Specific Immune Responses in a Novel Humanized Mouse Model

(2013) Chen Sabrina Tan et al.   PLoS One

CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria

(2013) F. Heuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants

(2013) Roberto Gramignoli et al.   Stem Cell Research

Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection

(2013) Obinna Chijioke et al.   Cell Reports

Adhesion of Neisseria meningitidis to Dermal Vessels Leads to Local Vascular Damage and Purpura in a Humanized Mouse Model

(2013) Keira Melican et al.   PLoS Pathogens

Human Cytomegalovirus Infection Leads to Elevated Levels of Transplant Arteriosclerosis in a Humanized Mouse Aortic Xenograft Model

(2012) S. Abele-Ohl et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/ cnull mouse

(2012) M. Suzuki et al.   INTERNATIONAL IMMUNOLOGY

Allergen-induced IgE-dependent gut inflammation in a human PBMC–engrafted murine model of allergy

(2012) Benno Weigmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human pharmacogenetic analysis in chimeric mice with ‘humanized livers’

(2012) Yajing Hu et al.   Pharmacogenetics and Genomics

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

(2012) Wendy W. J. Unger et al.   PLoS One

New generation humanized mice for virus research: Comparative aspects and future prospects

(2012) Ramesh Akkina   VIROLOGY

Animal Models of Dengue Virus Infection

(2012) Simona Zompi et al.   Viruses-Basel

Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

(2012) Anja Kathrin Wege et al.   PLoS Neglected Tropical Diseases

Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2−/−IL-2Rγ−/− mice: A promising model for studying human disease

(2011) Danieli Andrade et al.   ARTHRITIS AND RHEUMATISM

The reconstituted ‘humanized liver’ in TK-NOG mice is mature and functional

(2011) Masami Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease

(2011) Michael L. Washburn et al.   GASTROENTEROLOGY

CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease

(2011) Helen Martin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice

(2011) Wenwei Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epstein-Barr Virus Induces Erosive Arthritis in Humanized Mice

(2011) Yoshikazu Kuwana et al.   PLoS One

Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever

(2011) R. Vuyyuru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2r null Ins2Akita Mice

(2010) M. A. Brehm et al.   DIABETES

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

(2010) Karl-Dimiter Bissig et al.   JOURNAL OF CLINICAL INVESTIGATION

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Humanized nonobese diabetic-scid IL2r null mice are susceptible to lethal Salmonella Typhi infection

(2010) S. J. Libby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD-scid IL2rγnull Mouse Model of Human Skin Transplantation and Allograft Rejection

(2010) Waldemar J. Racki et al.   TRANSPLANTATION

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

(2009) Till Strowig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell–Mediated Control of Epstein‐Barr Virus Infection in Humanized Mice

(2009) Misako Yajima et al.   JOURNAL OF INFECTIOUS DISEASES

Mucosal Innate and Adaptive Immune Responses against Herpes Simplex Virus Type 2 in a Humanized Mouse Model

(2009) A. Kwant-Mitchell et al.   JOURNAL OF VIROLOGY

Neonatal Chimerization with Human Glial Progenitor Cells Can Both Remyelinate and Rescue the Otherwise Lethally Hypomyelinated Shiverer Mouse

(2008) Martha S. Windrem et al.   Cell Stem Cell

A New Humanized Mouse Model of Epstein‐Barr Virus Infection That Reproduces Persistent Infection, Lymphoproliferative Disorder, and Cell‐Mediated and Humoral Immune Responses

(2008) Misako Yajima et al.   JOURNAL OF INFECTIOUS DISEASES