Macrophage Polarization: Anti-Cancer Strategies to Target Tumor-Associated Macrophage in Breast Cancer

Tumor-associated macrophages and anti-tumor therapies: complex links

(2016) Cristina Belgiovine et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

(2016) Ryan Kolb et al.   Nature Communications

microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer

(2015) Jen N. Goh et al.   BIOLOGICAL REVIEWS

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

(2015) Satu Tiainen et al.   HISTOPATHOLOGY

Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines

(2015) Sonia Ávila-Arroyo et al.   Journal of Breast Cancer

Essential Role of Lysophosphatidylcholine Acyltransferase 3 in the Induction of Macrophage Polarization in PMA-Treated U937 Cells

(2015) Kosuke Taniguchi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Role of Cytokines in Breast Cancer Development and Progression

(2015) Marcela Esquivel-Velázquez et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

(2015) Pijus K. Mandal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic potential of chemokine signal inhibition for metastatic breast cancer

(2015) Takanori Kitamura et al.   PHARMACOLOGICAL RESEARCH

Targeting breast cancer through its microenvironment: Current status of preclinical and clinical research in finding relevant targets

(2015) H.H. Nienhuis et al.   PHARMACOLOGY & THERAPEUTICS

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells

(2015) Hsueh-Te Lee et al.   Oncotarget

Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages

(2015) Samira Khabbazi et al.   Scientific Reports

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Induced PD-L1 Expression Mediates Acquired Resistance to Agonistic Anti-CD40 Treatment

(2015) A. Zippelius et al.   Cancer Immunology Research

Hyaluronan, Inflammation, and Breast Cancer Progression

(2015) Kathryn L. Schwertfeger et al.   Frontiers in Immunology

Chemokines in tumor progression and metastasis

(2015) Purvaba J. Sarvaiya et al.   Oncotarget

Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs

(2014) Xuemei Jia et al.   BREAST CANCER RESEARCH AND TREATMENT

Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells

(2014) Yifang Wei et al.   BREAST CANCER RESEARCH AND TREATMENT

Trabectedin, a drug acting on both cancer cells and the tumour microenvironment

(2014) M D’Incalci et al.   BRITISH JOURNAL OF CANCER

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

(2014) Nesrine I. Affara et al.   CANCER CELL

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

A decade of progress in adipose tissue macrophage biology

(2014) Andrea A. Hill et al.   IMMUNOLOGICAL REVIEWS

Macrophage Polarization in Inflammatory Diseases

(2014) Yan-Cun Liu et al.   International Journal of Biological Sciences

Dimethyl Sulfoxide Suppresses Mouse 4T1 Breast Cancer Growth by Modulating Tumor-Associated Macrophage Differentiation

(2014) Rui Deng et al.   Journal of Breast Cancer

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

(2014) S. Matsumura et al.   JOURNAL OF IMMUNOLOGY

Fusions of Dendritic Cells with Breast Carcinoma Stimulate the Expansion of Regulatory T Cells while Concomitant Exposure to IL-12, CpG Oligodeoxynucleotides, and Anti-CD3/CD28 Promotes the Expansion of Activated Tumor Reactive Cells

(2014) B. Vasir et al.   JOURNAL OF IMMUNOLOGY

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

(2014) E. Sierra-Filardi et al.   JOURNAL OF IMMUNOLOGY

Harnessing the immune system for the treatment of breast cancer

(2014) Xinguo Jiang   Journal of Zhejiang University-SCIENCE B

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer

(2014) Parvin Forghani et al.   Cancer Medicine

The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets

(2014) M. Isabel Palacios-Arreola et al.   Journal of Immunology Research

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

CTLA-4Ig immunotherapy of obesity-induced insulin resistance by manipulation of macrophage polarization in adipose tissues

(2013) Masakazu Fujii et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

(2013) Ji-Young Jang et al.   BMC CANCER

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors

(2013) Shahneen K. Sandhu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

(2013) Xiaoqiang Tang   CANCER LETTERS

CCL5 as a potential immunotherapeutic target in triple-negative breast cancer

(2013) Dandan Lv et al.   Cellular & Molecular Immunology

Tumor microenvironment profoundly modifies functional status of macrophages: Peritoneal and tumor-associated macrophages are two very different subpopulations

(2013) Dayron Rodríguez et al.   CELLULAR IMMUNOLOGY

Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer

(2013) L. R. Howe et al.   CLINICAL CANCER RESEARCH

Tumour-associated macrophages and cancer

(2013) Jenny Cook et al.   CURRENT OPINION IN PHARMACOLOGY

Role of adipokines and cytokines in obesity-associated breast cancer: Therapeutic targets

(2013) Sajid Khan et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tumor associated macrophages and neutrophils in cancer

(2013) Maria Rosaria Galdiero et al.   IMMUNOBIOLOGY

Targeting tumor-infiltrating macrophages to combat cancer

(2013) Roheena Z Panni et al.   Immunotherapy

The role of tumor-associated macrophages in breast cancer progression

(2013) ELIAS OBEID et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

STAT signaling in different breast cancer sub-types

(2013) Priscilla A. Furth   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Immunotherapeutic approaches in triple-negative breast cancer: latest research and clinical prospects

(2013) John Stagg et al.   Therapeutic Advances in Medical Oncology

The development of denosumab for the treatment of diseases of bone loss and cancer-induced bone destruction

(2012) Carsten Goessl et al.   Annals of the New York Academy of Sciences

Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine

(2012) Bryan N. Brown et al.   BIOMATERIALS

A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling

(2012) Lucy Liu et al.   CANCER BIOLOGY & THERAPY

Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

(2012) Elizabeth S. Nakasone et al.   CANCER CELL

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

(2012) M. A. Swartz et al.   CANCER RESEARCH

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

(2012) A. Tsuyada et al.   CANCER RESEARCH

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models

(2012) Massimo Zollo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Breast cancer immunobiology driving immunotherapy: vaccines and immune checkpoint blockade

(2012) Leisha A Emens   Expert Review of Anticancer Therapy

Curcumin molecular targets in obesity and obesity-related cancers

(2012) Adeeb Shehzad et al.   Future Oncology

Anti-tumour strategies aiming to target tumour-associated macrophages

(2012) Xiaoqiang Tang et al.   IMMUNOLOGY

Optimized dosing of a CCR2 antagonist for amplification of vaccine immunity

(2012) Leah A. Mitchell et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections

(2012) Juan de Dios Rosado et al.   International Journal of Biological Sciences

Furanodiene enhances tamoxifen-induced growth inhibitory activity of ERa-positive breast cancer cells in a PPARγ independent manner

(2012) Zhang-Feng Zhong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt5a Induces a Tolerogenic Phenotype of Macrophages in Sepsis and Breast Cancer Patients

(2012) C. Bergenfelz et al.   JOURNAL OF IMMUNOLOGY

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

(2011) O. M. Pello et al.   BLOOD

Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

(2011) Laszlo Otvos et al.   BMC BIOTECHNOLOGY

Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression

(2011) Xuezheng Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

The association between vascular endothelial growth factor expression in invasive breast cancer and survival varies with intrinsic subtypes and use of adjuvant systemic therapy: results from the Nurses’ Health Study

(2011) Ying Liu et al.   BREAST CANCER RESEARCH AND TREATMENT

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

(2011) M. Chmielewski et al.   CANCER RESEARCH

Tumor-Associated Macrophages Mediate Immunosuppression in the Renal Cancer Microenvironment by Activating the 15-Lipoxygenase-2 Pathway

(2011) I. Daurkin et al.   CANCER RESEARCH

S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways

(2011) M. W. Nasser et al.   CANCER RESEARCH

Cancer-promoting tumor-associated macrophages: New vistas and open questions

(2011) Alberto Mantovani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage regulation of tumor angiogenesis: Implications for cancer therapy

(2011) Mario Leonardo Squadrito et al.   MOLECULAR ASPECTS OF MEDICINE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications

(2011) Antonio Macciò et al.   TheScientificWorldJOURNAL

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

(2010) Michael J. Campbell et al.   BREAST CANCER RESEARCH AND TREATMENT

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Signal transducer and activator of transcription 3 inhibitors: a patent review

(2010) Brent DG Page et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Clinical overview of sorafenib in breast cancer

(2010) Alvaro Moreno-Aspitia   Future Oncology

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages

(2010) Justin P. Edwards et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer

(2010) Karen M. Bussard et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

NF-κB as a central regulator of macrophage function in tumors

(2010) Subhra K. Biswas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking via the Chemokine Receptor CCR2, a Model for Tumorigenesis

(2010) Ge Jin et al.   PLoS One

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors

(2010) Jianyong Chen et al.   ACS Medicinal Chemistry Letters

Clinical Use of Anti-CD25 Antibody Daclizumab to Enhance Immune Responses to Tumor Antigen Vaccination by Targeting Regulatory T cells

(2009) Andrew J. Rech et al.   Annals of the New York Academy of Sciences

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

(2009) S. J. Priceman et al.   BLOOD

Granulocyte Macrophage Colony-Stimulating Factor Inhibits Breast Cancer Growth and Metastasis by Invoking an Anti-Angiogenic Program in Tumor-Educated Macrophages

(2009) T. D. Eubank et al.   CANCER RESEARCH

Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance

(2009) Mitsuhisa Tabata et al.   Cell Metabolism

Cellular and molecular pathways linking inflammation and cancer

(2009) Chiara Porta et al.   IMMUNOBIOLOGY

Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression

(2009) Hiroshi Fujimoto et al.   INTERNATIONAL JOURNAL OF CANCER

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

(2009) C. L. Manthey et al.   MOLECULAR CANCER THERAPEUTICS

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS

The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages

(2008) Paola Allavena et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Cisplatin primes murine peritoneal macrophages for enhanced expression of nitric oxide, proinflammatory cytokines, TLRs, transcription factors and activation of MAP kinases upon co-incubation with L929 cells

(2008) Puja Chauhan et al.   IMMUNOBIOLOGY

High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma

(2008) Xiao-Dong Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor-Associated Macrophage-Induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction

(2008) Jeng-Wei Tjiu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor

(2008) N Brownlow et al.   LEUKEMIA

Inflammation in obesity-related diseases

(2008) Robert W. O'Rourke   SURGERY