Curcumin molecular targets in obesity and obesity-related cancers

The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids

(2011) Mohamed A. El-Moselhy et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis

(2011) Sayaka Mito et al.   FREE RADICAL RESEARCH

Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin

(2011) Jiong Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/β-catenin signaling

(2010) Jiyun Ahn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK

(2010) Pomila Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives

(2010) Darren L. Roberts et al.   Annual Review of Medicine

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

(2010) Bharat B. Aggarwal   Annual Review of Nutrition

Curcumin in Cancer Chemoprevention: Molecular Targets, Pharmacokinetics, Bioavailability, and Clinical Trials

(2010) Adeeb Shehzad et al.   ARCHIV DER PHARMAZIE

Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase

(2010) Youcai Tang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin Protects Hepatic Stellate Cells against Leptin-Induced Activationin Vitroby Accumulating Intracellular Lipids

(2010) Youcai Tang et al.   ENDOCRINOLOGY

Redox modulation and human bile duct cancer inhibition by curcumin

(2010) Bunliang Suphim et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibitory effect of curcumin on uterine leiomyoma cell proliferation

(2010) Kenji Tsuiji et al.   GYNECOLOGICAL ENDOCRINOLOGY

Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPα during oral cancer suppression

(2010) Kuo-Wei Chang et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis

(2010) Suksanti Prakobwong et al.   INTERNATIONAL JOURNAL OF CANCER

Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis

(2010) Judith Ertle et al.   INTERNATIONAL JOURNAL OF CANCER

A new way of targeting to treat coronary artery disease

(2010) David Siu   Journal of Cardiovascular Medicine

Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin

(2010) Jung-Mi Yun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies

(2010)   LANCET ONCOLOGY

Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells

(2010) Mayank Singh et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2

(2010) Jianguo Lin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet

(2010) Minji Kim et al.   Nutrition Research and Practice

Leptin and gastro-intestinal malignancies

(2010) J. M. Howard et al.   Obesity Reviews

Curcumin adds spice to the debate: lipid metabolism in liver disease

(2009) Annette Graham   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin Eliminates Leptin’s Effects on Hepatic Stellate Cell Activation via Interrupting Leptin Signaling

(2009) Youcai Tang et al.   ENDOCRINOLOGY

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

(2009) Asma Ejaz et al.   JOURNAL OF NUTRITION

Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities

(2009) Janice B. B. Lam et al.   PLoS One

Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2

(2008) Koremu K. Meja et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Curcumin Supplementation Lowers TNF-α, IL-6, IL-8, and MCP-1 Secretion in High Glucose-Treated Cultured Monocytes and Blood Levels of TNF-α, IL-6, MCP-1, Glucose, and Glycosylated Hemoglobin in Diabetic Rats

(2008) Sushil K. Jain et al.   ANTIOXIDANTS & REDOX SIGNALING

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

(2008) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells

(2008) O Treeck et al.   BRITISH JOURNAL OF CANCER

Reduced Susceptibility to Two-Stage Skin Carcinogenesis in Mice with Low Circulating Insulin-Like Growth Factor I Levels

(2008) T. Moore et al.   CANCER RESEARCH

Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor

(2008) L. P. Volak et al.   DRUG METABOLISM AND DISPOSITION

Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity

(2008) Stuart P. Weisberg et al.   ENDOCRINOLOGY

Curcumin Blocks the Activation of Androgen and Interlukin-6 on Prostate-Specific Antigen Expression in Human Prostatic Carcinoma Cells

(2008) K.-H. Tsui et al.   JOURNAL OF ANDROLOGY

Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat–fed hamsters

(2008) Eun-Mi Jang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes

(2008) Amanda M Gonzales et al.   Nutrition & Metabolism

Induction of adiponectin by natural and synthetic phenolamides in mouse and human preadipocytes and its enhancement by docosahexaenoic acid

(2007) Yoshimitsu Yamazaki et al.   LIFE SCIENCES