Signal transducer and activator of transcription 3 inhibitors: a patent review

A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes

(2010) Xiaolei Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3

(2010) Zu-Yin Yu et al.   INTERNATIONAL JOURNAL OF CANCER

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

(2010) F. Okumura et al.   JOURNAL OF CELL SCIENCE

Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis

(2010) Nagathihalli S. Nagaraj et al.   MOLECULAR CANCER THERAPEUTICS

Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway

(2010) J. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors

(2010) Jianyong Chen et al.   ACS Medicinal Chemistry Letters

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein

(2009) Steven Fletcher et al.   Biochemistry and Cell Biology

Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities

(2009) Steven Fletcher et al.   CHEMBIOCHEM

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein–protein interactions

(2009) Joel A. Drewry et al.   CHEMICAL COMMUNICATIONS

Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

(2009) Xuejun Xu et al.   PLoS One

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS

Lack of toxicity of a STAT3 decoy oligonucleotide

(2008) Malabika Sen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting Protein-Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small-Molecule, Nonpeptidic SH2 Domain Binders

(2008) Patrick T. Gunning et al.   CHEMBIOCHEM

Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein

(2008) Steven Fletcher et al.   ChemMedChem

Inhibition of transcription factors with small organic molecules

(2008) Thorsten Berg   CURRENT OPINION IN CHEMICAL BIOLOGY

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Design, synthesis, and studies of small molecule STAT3 inhibitors

(2007) Deepak Bhasin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS