A decade of progress in adipose tissue macrophage biology

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Mechanisms That Regulate Macrophage Burden in Atherosclerosis

(2014) Gwendalyn J Randolph   CIRCULATION RESEARCH

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

(2014) Bhama Ramkhelawon et al.   NATURE MEDICINE

Docosahexaenoic Acid Decreases Pro-Inflammatory Mediators in an In Vitro Murine Adipocyte Macrophage Co-Culture Model

(2014) Anna A. De Boer et al.   PLoS One

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

Intraperitoneal Injection of Clodronate Liposomes Eliminates Visceral Adipose Macrophages and Blocks High-fat Diet-induced Weight Gain and Development of Insulin Resistance

(2013) Le Bu et al.   AAPS Journal

Loss of CCR5 results in glucose intolerance in diet-induced obese mice

(2013) Arion Kennedy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

Adipose Tissue Macrophages Are Innate to the Immunological Awareness of Adipose Tissue

(2013) Vishwa Deep Dixit   DIABETES

Weight Cycling Increases T-Cell Accumulation in Adipose Tissue and Impairs Systemic Glucose Tolerance

(2013) Emily K. Anderson et al.   DIABETES

Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution

(2013) J. S. Orr et al.   DIABETES

Adipose Tissue Macrophages Function As Antigen-Presenting Cells and Regulate Adipose Tissue CD4 + T Cells in Mice

(2013) David L. Morris et al.   DIABETES

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

Bone Marrow Leptin Signaling Mediates Obesity-Associated Adipose Tissue Inflammation in Male Mice

(2013) Lea H. Dib et al.   ENDOCRINOLOGY

What Have We Really Learned About Macrophage Recruitment to Adipose Tissue?

(2013) Alyssa H. Hasty et al.   ENDOCRINOLOGY

Adipose Tissue Foam Cells Are Present in Human Obesity

(2013) Hagit Shapiro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes

(2013) Timothy J. Sullivan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fatty Acids Regulate Endothelial Lipase and Inflammatory Markers in Macrophages and in Mouse Aorta

(2012) Un Ju Jung et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stearic Acid Accumulation in Macrophages Induces Toll-Like Receptor 4/2-Independent Inflammation Leading to Endoplasmic Reticulum Stress–Mediated Apoptosis

(2012) Emily K. Anderson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

(2012) H. Kitade et al.   DIABETES

Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages

(2012) J. S. Orr et al.   DIABETES

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

(2012) Shawn Winer et al.   IMMUNOLOGY AND CELL BIOLOGY

Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization in Adipose Tissue and Improves Systemic Glucose Tolerance via Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity

(2012) Yewei Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunological complications of obesity

(2012) Thirumala-Devi Kanneganti et al.   NATURE IMMUNOLOGY

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Multiparity leads to obesity and inflammation in mothers and obesity in male offspring

(2011) Sandra L. Rebholz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activating Transcription Factor 1 Directs Mhem Atheroprotective Macrophages Through Coordinated Iron Handling and Foam Cell Protection

(2011) Joseph J. Boyle et al.   CIRCULATION RESEARCH

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity

(2011) Dario A. Gutierrez et al.   DIABETES

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice

(2011) Jason Hellmann et al.   FASEB JOURNAL

C-C Chemokine Receptor 2 Inhibitor Improves Diet-Induced Development of Insulin Resistance and Hepatic Steatosis in Mice

(2011) Yukinori Tamura et al.   Journal of Atherosclerosis and Thrombosis

Molecular Mechanism for Adiponectin-dependent M2 Macrophage Polarization

(2011) Palash Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity

(2011) Dario A Gutierrez et al.   JOURNAL OF ENDOCRINOLOGY

Hemoglobin Directs Macrophage Differentiation and Prevents Foam Cell Formation in Human Atherosclerotic Plaques

(2011) Aloke V. Finn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice

(2011) Bin Feng et al.   PLoS One

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Incident Diabetes in Relation to Weight Patterns During Middle Age

(2010) M. E. Waring et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Absence of macrophage inflammatory protein-1α does not impact macrophage accumulation in adipose tissue of diet-induced obese mice

(2010) Bonnie K. Surmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages

(2010) Fina Lovren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

Polarization dictates iron handling by inflammatory and alternatively activated macrophages

(2010) G. Corna et al.   HAEMATOLOGICA

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

(2010) Attila Szanto et al.   IMMUNITY

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

(2010) Pingping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype

(2009) Joseph J. Boyle et al.   AMERICAN JOURNAL OF PATHOLOGY

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Long-Chain Acyl Coenzyme A Synthetases During Fatty Acid Loading Induces Lipotoxicity in Macrophages

(2009) Viswanathan Saraswathi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Differential regulation of iron homeostasis during human macrophage polarized activation

(2009) Stefania Recalcati et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

(2009) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Adipose Tissue Macrophages: M1 and M2 Cell Surface Markers in Subcutaneous and Omental Depots and after Weight Loss

(2009) Judith Aron-Wisnewsky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4himonocytes in obesity

(2009) Daniel J. Westcott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary Fish Oil Exerts Hypolipidemic Effects in Lean and Insulin Sensitizing Effects in Obese LDLR−/− Mice

(2009) Viswanathan Saraswathi et al.   JOURNAL OF NUTRITION

T-ing up inflammation in fat

(2009) Carey N. Lumeng et al.   NATURE MEDICINE

Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?

(2008) Paul Trayhurn et al.   BRITISH JOURNAL OF NUTRITION

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

(2008) V. Bourlier et al.   CIRCULATION

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue

(2008) E. A. Kirk et al.   DIABETES

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

Peroxisome Proliferator-activated Receptor γ Activation Promotes Infiltration of Alternatively Activated Macrophages into Adipose Tissue

(2008) Rinke Stienstra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CC Chemokine and CC Chemokine Receptor Profiles in Visceral and Subcutaneous Adipose Tissue Are Altered in Human Obesity

(2008) Joakim Huber et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity

(2008) Sara N. Vallerie et al.   PLoS One

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE