The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1

Choosing the right chondrocyte cell line: Focus on nitric oxide

(2015) Anna Santoro et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice

(2015) Yun-peng Zhao et al.   Scientific Reports

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling

(2014) Yun-peng Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Novel immunological targets in rheumatic diseases: clues from current therapies

(2014) Fulvio D’Acquisto et al.   DRUG DISCOVERY TODAY

Circulating PGRN Is Significantly Associated With Systemic Insulin Sensitivity and Autophagic Activity in Metabolic Syndrome

(2014) Huixia Li et al.   ENDOCRINOLOGY

Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity

(2014) Qingyun Tian   Frontiers in Bioscience-Landmark

Increased Serum GP88 (Progranulin) Concentrations in Rheumatoid Arthritis

(2014) Yasuko Yamamoto et al.   INFLAMMATION

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling

(2013) Yun-peng Zhao et al.   BIOMATERIALS

Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice

(2013) Yun-Peng Zhao et al.   FEBS LETTERS

Progranulin Protects Vascular Endothelium against Atherosclerotic Inflammatory Reaction via Akt/eNOS and Nuclear Factor-κB Pathways

(2013) Hwan-Jin Hwang et al.   PLoS One

PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue

(2012) Toshiya Matsubara et al.   Cell Metabolism

Insights into the role of progranulin in immunity, infection, and inflammation

(2012) J. Jian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Adiponectin and Leptin Induce VCAM-1 Expression in Human and Murine Chondrocytes

(2012) Javier Conde et al.   PLoS One

Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes

(2011) J. Conde et al.   ANNALS OF THE RHEUMATIC DISEASES

Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity

(2011) Javier Conde et al.   BIOFACTORS

Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1

(2011) Pu Wang et al.   FASEB JOURNAL

Hyaluronan in part mediates IL-1beta-induced inflammation in mouse chondrocytes by up-regulating CD44 receptors

(2011) Giuseppe M. Campo et al.   GENE

What's new in our understanding of the role of adipokines in rheumatic diseases?

(2011) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Progranulin Resolves Inflammation

(2011) H. Wu et al.   SCIENCE

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Expression and modulation of ghrelinO-acyltransferase in cultured chondrocytes

(2009) Rodolfo Gómez et al.   ARTHRITIS AND RHEUMATISM

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-1β Augments TNF-α–Mediated Inflammatory Responses from Lung Epithelial Cells

(2009) Sara Saperstein et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor

(2009) X.-H. Bai et al.   MOLECULAR AND CELLULAR BIOLOGY

Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue

(2008) B.-S. Youn et al.   DIABETES

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes

(2008) R. Lago et al.   OSTEOARTHRITIS AND CARTILAGE