A review of gradient stiffness hydrogels used in tissue engineering and regenerative medicine

Liquid Crystal Droplet-Embedded Biopolymer Hydrogel Sheets for Biosensor Applications

(2016) Jinan Deng et al.   ACS Applied Materials & Interfaces

Fabrication of Aligned Nanofiber Polymer Yarn Networks for Anisotropic Soft Tissue Scaffolds

(2016) Shaohua Wu et al.   ACS Applied Materials & Interfaces

Nondestructive evaluation of a new hydrolytically degradable and photo-clickable PEG hydrogel for cartilage tissue engineering

(2016) Alexander J. Neumann et al.   Acta Biomaterialia

Wide-range stiffness gradient PVA/HA hydrogel to investigate stem cell differentiation behavior

(2016) Se Heang Oh et al.   Acta Biomaterialia

Bio-Inspired Mechanotactic Hybrids for Orchestrating Traction-Mediated Epithelial Migration

(2016) Pingqiang Cai et al.   ADVANCED MATERIALS

Glycosaminoglycan-Mimetic Signals Direct the Osteo/Chondrogenic Differentiation of Mesenchymal Stem Cells in a Three-Dimensional Peptide Nanofiber Extracellular Matrix Mimetic Environment

(2016) Elif Arslan et al.   BIOMACROMOLECULES

Enantiomorphous Periodic Mesoporous Organosilica-Based Nanocomposite Hydrogel Scaffolds for Cell Adhesion and Cell Enrichment

(2016) Nermin Seda Kehr   BIOMACROMOLECULES

Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation

(2016) Angelo S. Mao et al.   BIOMATERIALS

Microscale characterization of the viscoelastic properties of hydrogel biomaterials using dual-mode ultrasound elastography

(2016) Xiaowei Hong et al.   BIOMATERIALS

CD44 alternative splicing in gastric cancer cells is regulated by culture dimensionality and matrix stiffness

(2016) Cristiana Branco da Cunha et al.   BIOMATERIALS

A versatile fluorescent biosensor based on target-responsive graphene oxide hydrogel for antibiotic detection

(2016) Bing Tan et al.   BIOSENSORS & BIOELECTRONICS

Treatment of critically sized femoral defects with recombinant BMP-2 delivered by a modified mPEG-PLGA biodegradable thermosensitive hydrogel

(2016) Kuo-Ti Peng et al.   BMC MUSCULOSKELETAL DISORDERS

The self-crosslinking smart hyaluronic acid hydrogels as injectable three-dimensional scaffolds for cells culture

(2016) Shaoquan Bian et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification

(2016) Jeffrey J Hsu et al.   HEART

Physically crosslinked-sacran hydrogel films for wound dressing application

(2016) Nasrul Wathoni et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing

(2016) Qiong Jiang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Endothelial directed collective migration depends on substrate stiffness via localized myosin contractility and cell-matrix interactions

(2016) Adam Charles Canver et al.   JOURNAL OF BIOMECHANICS

Substrate stiffness modulates lung cancer cell migration but not epithelial to mesenchymal transition

(2016) V. C. Shukla et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology

(2016) Daniel B. Deegan et al.   Journal of the Mechanical Behavior of Biomedical Materials

Corrigendum to “Porous hydrogel of wool keratin prepared by a novel method: An extraction with guanidine/2-mercaptoethanol solution followed by a dialysis” [Mater. Sci. Eng. C (2014), Volume 42, pp. 146–154]

(2016) Yuki Ozaki et al.   Materials Science & Engineering C-Materials for Biological Applications

Portal Hypertension in Patients with Liver Cirrhosis: Diagnostic Accuracy of Spleen Stiffness

(2016) Yoshitaka Takuma et al.   RADIOLOGY

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

A highly sensitive and stable glucose biosensor using thymine-based polycations into laponite hydrogel films

(2016) Veronica I. Paz Zanini et al.   TALANTA

Ultrasound Imaging Techniques for Spatiotemporal Characterization of Composition, Microstructure, and Mechanical Properties in Tissue Engineering

(2016) Cheri X. Deng et al.   TISSUE ENGINEERING PART B-REVIEWS

Ultrasound stimulated release of mimosa medicine from cellulose hydrogel matrix

(2016) Huixin Jiang et al.   ULTRASONICS SONOCHEMISTRY

Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

(2016) Masao Kamimura et al.   Biomaterials Science

Measuring the Elastic Modulus of Thin Polymer Sheets by Elastocapillary Bending

(2015) Jinhye Bae et al.   ACS Applied Materials & Interfaces

Mechanical loading regulates human MSC differentiation in a multi-layer hydrogel for osteochondral tissue engineering

(2015) Neven J. Steinmetz et al.   Acta Biomaterialia

Two-Dimensional Photonic Crystal Chemical and Biomolecular Sensors

(2015) Zhongyu Cai et al.   ANALYTICAL CHEMISTRY

Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing–thawing method to investigate stem cell differentiation behaviors

(2015) Tae Ho Kim et al.   BIOMATERIALS

Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis

(2015) Laura J. Bray et al.   BIOMATERIALS

3D printed microfluidic devices with integrated valves

(2015) Chad I. Rogers et al.   Biomicrofluidics

Endothelial cell sensing, restructuring, and invasion in collagen hydrogel structures

(2015) Y. Hosseini et al.   Integrative Biology

Hyperbranched poly(glycidol)/poly(ethylene oxide) crosslinked hydrogel for tissue engineering scaffold using e-beams

(2015) Haryanto et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype

(2015) Luke Cassereau et al.   JOURNAL OF BIOTECHNOLOGY

Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis

(2015) Nduka O. Enemchukwu et al.   JOURNAL OF CELL BIOLOGY

Dewetting based fabrication of fibrous micro-scaffolds as potential injectable cell carriers

(2015) Hokyung Song et al.   Materials Science & Engineering C-Materials for Biological Applications

A Highly Tunable and Fully Biocompatible Silk Nanoplasmonic Optical Sensor

(2015) Myungjae Lee et al.   NANO LETTERS

Prospective Comparison of Spleen and Liver Stiffness by Using Shear-Wave and Transient Elastography for Detection of Portal Hypertension in Cirrhosis

(2015) Laure Elkrief et al.   RADIOLOGY

A synthetic hydrogel for the high-throughput study of cell–ECM interactions

(2015) Andrew D. Rape et al.   Nature Communications

Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery

(2015) Yeshun Zhang et al.   Scientific Reports

Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells

(2015) Catia S. Verbeke et al.   Advanced Healthcare Materials

Engineering alginate as bioink for bioprinting

(2014) Jia Jia et al.   Acta Biomaterialia

3D Tissue Engineered Supramolecular Hydrogels for Controlled Chondrogenesis of Human Mesenchymal Stem Cells

(2014) Hyuntae Jung et al.   BIOMACROMOLECULES

Micro-composite substrates for the study of cell-matrix mechanical interactions

(2014) Pen-hsiu Grace Chao et al.   Journal of the Mechanical Behavior of Biomedical Materials

A new 3D concentration gradient maker and its application in building hydrogels with a 3D stiffness gradient

(2014) Gianni Orsi et al.   Journal of Tissue Engineering and Regenerative Medicine

A review of hydrogel use in fracture healing and bone regeneration

(2014) David M. R. Gibbs et al.   Journal of Tissue Engineering and Regenerative Medicine

Time-Dependent Migratory Behaviors in the Long-Term Studies of Fibroblast Durotaxis on a Hydrogel Substrate Fabricated with a Soft Band

(2014) Thasaneeya Kuboki et al.   LANGMUIR

A Mild Strategy To Encapsulate Enzyme into Hydrogel Layer Grafted on Polymeric Substrate

(2014) Xing Zhu et al.   LANGMUIR

Porous hydrogel of wool keratin prepared by a novel method: An extraction with guanidine/2-mercaptoethanol solution followed by a dialysis

(2014) Yuki Ozaki et al.   Materials Science & Engineering C-Materials for Biological Applications

Micro/nano replication and 3D assembling techniques for scaffold fabrication

(2014) M.J. Lima et al.   Materials Science & Engineering C-Materials for Biological Applications

Biomimetic porous scaffolds for bone tissue engineering

(2014) Shuilin Wu et al.   MATERIALS SCIENCE & ENGINEERING R-REPORTS

Substrate Stiffness Regulates Filopodial Activities in Lung Cancer Cells

(2014) Yu-Ren Liou et al.   PLoS One

Diminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffness

(2014) M. Moazzem Hossain et al.   FEBS Open Bio

Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers

(2013) Ruogang Zhao et al.   ADVANCED MATERIALS

Liver stiffness increases acutely during sickle cell vaso-occlusive crisis

(2013) Christopher Koh et al.   AMERICAN JOURNAL OF HEMATOLOGY

Engineering interpenetrating network hydrogels as biomimetic cell niche with independently tunable biochemical and mechanical properties

(2013) Xinming Tong et al.   BIOMATERIALS

Bioimprinting strategies: From soft lithography to biomimetic sensors and beyond

(2013) Adnan Mujahid et al.   BIOTECHNOLOGY ADVANCES

Mechanical factors in embryonic tendon development: potential cues for stem cell tenogenesis

(2013) Nathan R Schiele et al.   CURRENT OPINION IN BIOTECHNOLOGY

Influence of crosslinking on the stiffness and degradation of dermis-derived hydrogels

(2013) Sophia P. Pilipchuk et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Prediction of mechanical properties of multilayer gradient hydroxyapatite reinforced poly(vinyl alcohol) gel biomaterial

(2013) Pan Yusong et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Mapping in vitro local material properties of intact and disrupted virions at high resolution using multi-harmonic atomic force microscopy

(2013) Alexander Cartagena et al.   Nanoscale

MMP-Sensitive PEG Diacrylate Hydrogels with Spatial Variations in Matrix Properties Stimulate Directional Vascular Sprout Formation

(2013) Michael V. Turturro et al.   PLoS One

Measurement of the Mechanical Failure of Polyvinyl Alcohol Sponge Using Biaxial Puncture Test

(2013) Alireza Karimi et al.   Journal of Biomaterials and Tissue Engineering

Formation and Antifouling Properties of Amphiphilic Coatings on Polypropylene Fibers

(2012) Kiran K. Goli et al.   BIOMACROMOLECULES

Gelatin-Based Emulsion Gels for Diffusion-Controlled Release Applications

(2012) Goutam Thakur et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Design, synthesis, imaging, and biomechanics of a softness-gradient hydrogel nucleus pulposus prosthesis in a canine lumbar spine model

(2012) Hendrik-Jan C. Kranenburg et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Fabrication of Hydrogels with Steep Stiffness Gradients for Studying Cell Mechanical Response

(2012) Raimon Sunyer et al.   PLoS One

Designing Cell-Compatible Hydrogels for Biomedical Applications

(2012) D. Seliktar   SCIENCE

Substrate Stiffness Modulates Gene Expression and Phenotype in Neonatal Cardiomyocytes In Vitro

(2012) Giancarlo Forte et al.   TISSUE ENGINEERING PART A

Fibroblast Morphology on Dynamic Softening of Hydrogels

(2011) Michelle L. Previtera et al.   ANNALS OF BIOMEDICAL ENGINEERING

Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound

(2011) Jason M. Walker et al.   ANNALS OF BIOMEDICAL ENGINEERING

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

Intervertebral disc properties: challenges for biodevices

(2011) John J Costi et al.   Expert Review of Medical Devices

Mimicking the functional hematopoietic stem cell niche in vitro: recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of mesenchymal stromal cells

(2011) M. B. Sharma et al.   HAEMATOLOGICA

Experimental validation of atomic force microscopy-based cell elasticity measurements

(2011) Andrew R Harris et al.   NANOTECHNOLOGY

Mapping nanomechanical properties of live cells using multi-harmonic atomic force microscopy

(2011) A. Raman et al.   Nature Nanotechnology

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

(2011) Justin R. Tse et al.   PLoS One

Analyzing the Anatomy of Integrin Adhesions

(2011) A. Byron   Science Signaling

Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination

(2010) April M. Kloxin et al.   ADVANCED MATERIALS

Two-photon lithography in the future of cell-based therapeutics and regenerative medicine: a review of techniques for hydrogel patterning and controlled release

(2010) Andrea M Kasko et al.   Future Medicinal Chemistry

Synthesis and Electrospinning of ε-Polycaprolactone-Bioactive Glass Hybrid Biomaterials via a Sol−Gel Process

(2010) Bedilu A. Allo et al.   LANGMUIR

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

Rapid Generation of Biologically Relevant Hydrogels Containing Long-Range Chemical Gradients

(2009) Jiankang He et al.   ADVANCED FUNCTIONAL MATERIALS

Synthetic Materials in the Study of Cell Response to Substrate Rigidity

(2009) Stephanie Nemir et al.   ANNALS OF BIOMEDICAL ENGINEERING

PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity

(2009) Stephanie Nemir et al.   BIOTECHNOLOGY AND BIOENGINEERING

Nanoindentation Methods to Measure Viscoelastic Properties of Single Cells Using Sharp, Flat, and Buckling Tips Inside ESEM

(2009) M.R. Ahmad et al.   IEEE TRANSACTIONS ON NANOBIOSCIENCE

Effect of Elongation of Alternating Sequences on Swelling Behavior and Large Deformation Properties of Natural Alginate Gels

(2009) Ivan Donati et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ultrasound monitoring of cartilaginous matrix evolution in degradable PEG hydrogels☆

(2008) M RICE et al.   Acta Biomaterialia

AFM indentation study of breast cancer cells

(2008) Q.S. Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gradient Hydrogel Matrix for Microarray and Biosensor Applications: An Imaging SPR Study

(2008) Olof Andersson et al.   BIOMACROMOLECULES

Sensor materials for the detection of proteases

(2008) Jacqueline L. Stair et al.   BIOSENSORS & BIOELECTRONICS

Elasticity measurement of living cells with an atomic force microscope: data acquisition and processing

(2008) Philippe Carl et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Characterization of the structure-function relationship at the ligament-to-bone interface

(2008) K. L. Moffat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA