Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 91, Issue -, Pages 85-91Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2016.05.077
Keywords
Chitosan; Hydrogel; Wound dressing
Funding
- Chinese Program for New Century Excellent Talents in Universities [NCET-11-0661]
- National Natural Science Foundation of China [21174054, 21004030]
- Scientific Research Foundation for Returned Scholars from Ministry of Education of China
- Natural Science Foundation of Anhui Province of China [1408085MB26]
- Academic and Technology Introduction Project of Anhui University of China [AU02303203]
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The objective of this study was to develop novel hydrogel films based on carboxyl-modified hypromellose-crosslinked chitosan for potential wound dressing. Hypromellose (HPMC) was grafted with succinic acid to yield hypromellose succinate (HPMCS), and then the reinforced hydrogel films of HPMCS-crosslinked chitosan (HPMCS-CS) were prepared through amide bond formation using 1-ethyl-3(3-dimethylaminopropyl)carbodiimide (EDC) and N- hydroxysuccinimide (NHS) as a catalyst. Compared to that of blend film, mechanical properties of HPMCS-CS hydrogel films were significantly enhanced both in dry and swollen state. To assess the applicability of HPMCS-CS hydrogel films as wound dressing, the swelling behavior, water vapor transmission rate (WVTR), oxygen permeability, biocompatibility (cytotoxicity and hemolysis), in vitro drug release and bactericidal properties were analyzed. The results indicated that HPMCS-CS hydrogel films with good biocompatibility possess high swelling ratio, proper WVTR, and oxygen permeability, which might accelerate tissue regeneration. Meanwhile, gentamycin sulfate release from drug-loaded HPMCS-CS hydrogel films were sustained, which would help to protect wound from infection. (C) 2016 Elsevier B.V. All rights reserved.
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