Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation

(2016) Khadija M Alawi et al.   ANNALS OF THE RHEUMATIC DISEASES

Natural and synthetic flavonoid modulation of TRPC5 channels

(2016) Jacqueline Naylor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics

(2016) Hannah J. Gaunt et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(−)-Englerin A-evoked Cytotoxicity Is Mediated by Na+Influx and Counteracted by Na+/K+-ATPase

(2016) Melanie J. Ludlow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC5 channels participate in pressure-sensing in aortic baroreceptors

(2016) On-Chai Lau et al.   Nature Communications

(−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

(2015) Yasemin Akbulut et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of orally-bioavailable antagonists of the TRPV4 ion-channel

(2015) Zhi-Liang Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

(2015) Yingmin Zhu et al.   BRITISH JOURNAL OF PHARMACOLOGY

A background Ca2+entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling

(2015) Juan E. Camacho Londoño et al.   EUROPEAN HEART JOURNAL

Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels

(2015) Hong Wei et al.   NEUROSCIENCE LETTERS

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation

(2015) Cheryl Carson et al.   PLoS One

Decreased Anxiety-Like Behavior and G q/11-Dependent Responses in the Amygdala of Mice Lacking TRPC4 Channels

(2014) A. Riccio et al.   JOURNAL OF NEUROSCIENCE

A rat knockout model implicates TRPC4 in visceral pain sensation

(2014) K.N. Westlund et al.   NEUROSCIENCE

The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

(2014) Fang Zheng et al.   Cells

In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?

(2013) Robin S Bon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Riluzole activates TRPC5 channels independently of PLC activity

(2013) Julia M Richter et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular pharmacology of store-operated CRAC channels

(2013) Amit Jairaman et al.   Channels

Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease

(2013) David J. Beech   CIRCULATION JOURNAL

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin

(2012) Piruthivi Sukumar et al.   CIRCULATION RESEARCH

GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels

(2011) Eman AL-Shawaf et al.   CELL CALCIUM

Transient Receptor Potential Channel 1 (TRPC1) Reduces Calcium Permeability in Heteromeric Channel Complexes

(2011) Ursula Storch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels

(2011) Y. Majeed et al.   MOLECULAR PHARMACOLOGY

Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions

(2011) Kwong Tai Cheng et al.   PLOS BIOLOGY

Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+)

(2010) Piruthivi Sukumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

Physiology and pathophysiology of canonical transient receptor potential channels

(2009) Joel Abramowitz et al.   FASEB JOURNAL

TRPC channel activation by extracellular thioredoxin

(2008) Shang-Zhong Xu et al.   NATURE