Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation

Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists

(2014) Lisa Rooney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality

(2013) Carole Sourbier et al.   CANCER CELL

Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy

(2013) Richard T Williams et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Design and Optimization of Selective Protein Kinase C θ (PKCθ) Inhibitors for the Treatment of Autoimmune Diseases

(2013) Juan-Miguel Jimenez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Target identification of small molecules based on chemical biology approaches

(2013) Yushi Futamura et al.   Molecular BioSystems

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Determining the mode of action of bioactive compounds

(2012) Marisa A. Azad et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Established and Emerging Trends in Computational Drug Discovery in the Structural Genomics Era

(2012) Olivier Taboureau et al.   CHEMISTRY & BIOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Species Difference of Esterase Expression and Hydrolase Activity in Plasma

(2012) Fatma Goksin Bahar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Englerin A Selectively Induces Necrosis in Human Renal Cancer Cells

(2012) Florian J. Sulzmaier et al.   PLoS One

Cell proliferation, calcium influx and calcium channels

(2011) Thierry Capiod   BIOCHIMIE

Chemical Synthesis of the Englerins

(2011) Rebecca H. Pouwer et al.   Chemistry-An Asian Journal

A Brief Synthesis of (−)-Englerin A

(2011) Zhenwu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Cardiac Ion Channel Safety Profiling on the IonWorks Quattro Automated Patch Clamp System

(2010) Xueying Cao et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

(2009) Matthieu Willot et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

QPatch: The Missing Link Between HTS and Ion Channel Drug Discovery

(2009) Yi Liu et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels

(2009) Nathaniel T. Blair et al.   JOURNAL OF GENERAL PHYSIOLOGY

Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, fromPhyllanthus engleri

(2008) Ranjala Ratnayake et al.   ORGANIC LETTERS