In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?

Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line

(2014) H.-T. Ma et al.   JOURNAL OF IMMUNOLOGY

Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease

(2013) David J. Beech   CIRCULATION JOURNAL

Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels

(2012) Hongni Jiang et al.   BIOCHEMICAL PHARMACOLOGY

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca2+entry pathways

(2012) H Schleifer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of endothelial cell Ca2+entry and transient receptor potential channels by Sigma-1 receptor ligands

(2012) Mohamed S Amer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction

(2012) Nicole Urban et al.   CELL CALCIUM

Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin

(2012) Piruthivi Sukumar et al.   CIRCULATION RESEARCH

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo

(2012) Jennifer Davis et al.   DEVELOPMENTAL CELL

Involvement of Phosphoinositide 3-Kinase and PTEN Protein in Mechanism of Activation of TRPC6 Protein in Vascular Smooth Muscle Cells

(2012) Michaël Monet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

(2012) Senthil Selvaraj et al.   JOURNAL OF CLINICAL INVESTIGATION

Orai1 calcium channels in the vasculature

(2012) David J Beech   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of Diacylglycerol–Sensitive TRPC Channels by Synthetic and Natural Steroids

(2012) Susanne Miehe et al.   PLoS One

Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells

(2012) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

Mechanism of Stretch-Induced Activation of the Mechanotransducer Zyxin in Vascular Cells

(2012) S. Suresh Babu et al.   Science Signaling

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

(2012) Norbert Weissmann et al.   Nature Communications

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

(2012) K. Quick et al.   Open Biology

The Role of TRP Proteins in Mast Cells

(2012) Marc Freichel et al.   Frontiers in Immunology

Cilostazol Suppresses Angiotensin II–Induced Vasoconstriction via Protein Kinase A–Mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel

(2011) Kinue Nishioka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages

(2011) Jean-Yves Tano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NSAIDs acutely inhibit TRPC channels in freshly isolated rat glomeruli

(2011) Daria V. Ilatovskaya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of murine cardiac contractility by activation of α1A-adrenergic receptor-operated Ca2+ entry

(2011) Marion C. Mohl et al.   CARDIOVASCULAR RESEARCH

A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction

(2011) Carole Jung et al.   CARDIOVASCULAR RESEARCH

GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels

(2011) Eman AL-Shawaf et al.   CELL CALCIUM

Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington's Disease Treatment

(2011) Jun Wu et al.   CHEMISTRY & BIOLOGY

TRPC Channels As Effectors of Cardiac Hypertrophy

(2011) Petra Eder et al.   CIRCULATION RESEARCH

Genetic and Pharmacologic Inhibition of the Ca2+ Influx Channel TRPC3 Protects Secretory Epithelia From Ca2+-Dependent Toxicity

(2011) Min Seuk Kim et al.   GASTROENTEROLOGY

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective diacylglycerol-induced Ca2+entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets

(2011) G. RAMANATHAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels

(2011) Y. Majeed et al.   MOLECULAR PHARMACOLOGY

Depletion of Intracellular Ca 2+ Stores Stimulates the Translocation of Vanilloid Transient Receptor Potential 4-C1 Heteromeric Channels to the Plasma Membrane

(2010) Xin Ma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases

(2010) Ching-On Wong et al.   BRITISH JOURNAL OF PHARMACOLOGY

The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels

(2010) A Singh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids

(2010) Y Majeed et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPC1 Is Essential for In Vivo Angiogenesis in Zebrafish

(2010) Peng-chun Yu et al.   CIRCULATION RESEARCH

The Constitutive Function of Native TRPC3 Channels Modulates Vascular Cell Adhesion Molecule-1 Expression in Coronary Endothelial Cells Through Nuclear Factor κB Signaling

(2010) Kathryn Smedlund et al.   CIRCULATION RESEARCH

Pharmacological Modulation of Diacylglycerol-Sensitive TRPC3/6/7 Channels

(2010) Christian Harteneck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Canonical Transient Receptor Potential 6 (TRPC6), a Redox-regulated Cation Channel

(2010) Sarabeth Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC5 Channel Sensitivities to Antioxidants and Hydroxylated Stilbenes

(2010) Jacqueline Naylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Canonical 3 (TRPC3) Mediates Thrombin-Induced Astrocyte Activation and Upregulates Its Own Expression in Cortical Astrocytes

(2010) H. Shirakawa et al.   JOURNAL OF NEUROSCIENCE

TRPC6 channels stimulated by angiotensin II are inhibited by TRPC1/C5 channel activity through a Ca2+- and PKC-dependent mechanism in native vascular myocytes

(2010) J. Shi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of TRPC1 channel in skeletal muscle function

(2009) Nadège Zanou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells

(2009) Rebecca R. Foster et al.   CELL CALCIUM

Small-Molecule Inhibitors of Store-Operated Calcium Entry

(2009) Zachary K. Sweeney et al.   ChemMedChem

A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension

(2009) Ying Yu et al.   CIRCULATION

Physiology and pathophysiology of canonical transient receptor potential channels

(2009) Joel Abramowitz et al.   FASEB JOURNAL

Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo

(2009) Volodymyr V. Tsvilovskyy et al.   GASTROENTEROLOGY

Chemico-genetic identification of drebrin as a regulator of calcium responses

(2009) Jason C. Mercer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Expression of transient receptor potential (TRP) channels in human and murine osteoblast-like cells

(2009) Elie Abed et al.   MOLECULAR MEMBRANE BIOLOGY

Simple 2,4-Diacylphloroglucinols as Classic Transient Receptor Potential-6 Activators--Identification of a Novel Pharmacophore

(2009) K. Leuner et al.   MOLECULAR PHARMACOLOGY

The puzzling role of TRPC3 channels in motor coordination

(2009) Mohamed Trebak   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

(2009) S. Kiyonaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of TRPC5 cation channels by halothane, chloroform and propofol

(2008) Y M Bahnasi et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPs in Our Senses

(2008) Nils Damann et al.   CURRENT BIOLOGY

TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne muscular dystrophy

(2008) O. L. Gervasio et al.   JOURNAL OF CELL SCIENCE

TRPC channel activation by extracellular thioredoxin

(2008) Shang-Zhong Xu et al.   NATURE

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect

(2005) Shang-Zhong Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY