Pharmacochaperoning in aDrosophilamodel system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism

Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism

(2017) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates

(2017) Shreyas Bhat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence determinants of the Caenhorhabditis elegans dopamine transporter dictating in vivo axonal export and synaptic localization

(2017) Sarah B. Robinson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CRISPR-Cas-Induced Mutants Identify a Requirement for dSTIM in Larval Dopaminergic Cells of Drosophila melanogaster

(2017) Trayambak Pathak et al.   G3-Genes Genomes Genetics

ACaenorhabditis elegansmodel to study dopamine transporter deficiency syndrome

(2016) Placido Illiano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The D1 family dopamine receptor,DopR, potentiates hind leg grooming behavior inDrosophila

(2016) E. Pitmon et al.   GENES BRAIN AND BEHAVIOR

Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells

(2016) Pieter Beerepoot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Rescue of a MisfoldedDrosophila melanogasterDopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones

(2016) Ameya Kasture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Operation of a homeostatic sleep switch

(2016) Diogo Pimentel et al.   NATURE

Treatment of Fabry’s Disease with the Pharmacologic Chaperone Migalastat

(2016) Dominique P. Germain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurofibromin Loss of Function Drives Excessive Grooming in Drosophila

(2016) Lanikea B. King et al.   G3-Genes Genomes Genetics

Dual Action of Zn2+on the Transport Cycle of the Dopamine Transporter

(2015) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Salt Bridge Linking the First Intracellular Loop with the C Terminus Facilitates the Folding of the Serotonin Transporter

(2015) Florian Koban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amphetamines, new psychoactive drugs and the monoamine transporter cycle

(2015) Harald H. Sitte et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tracking Single Serotonin Transporter Molecules at the Endoplasmic Reticulum and Plasma Membrane

(2014) Andreas Anderluh et al.   BIOPHYSICAL JOURNAL

Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood

(2014) Joanne Ng et al.   BRAIN

Molecular Basis of the Dominant Negative Effect of a Glycine Transporter 2 Mutation Associated with Hyperekplexia

(2014) Esther Arribas-González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin Transporter

(2014) Ali El-Kasaby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascending-dose study of noribogaine in healthy volunteers: Pharmacokinetics, pharmacodynamics, safety, and tolerability

(2014) Paul Glue et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effects of the Chemical Chaperone 4-Phenylbutylate on the Function of the Serotonin Transporter (SERT) Expressed in COS-7 Cells

(2013) Masayuki Fujiwara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction

(2013) Gary Rudnick et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Defining the blanks – Pharmacochaperoning of SLC6 transporters and ABC transporters

(2013) Peter Chiba et al.   PHARMACOLOGICAL RESEARCH

The solute carrier 6 family of transporters

(2012) Stefan Bröer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mutations in the GlyT2 Gene (SLC6A5) Are a Second Major Cause of Startle Disease

(2012) Eloisa Carta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

(2012) Simon Bulling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine in Drosophila: setting arousal thresholds in a miniature brain

(2011) B. Van Swinderen et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mutations in the Carboxyl-terminal SEC24 Binding Motif of the Serotonin Transporter Impair Folding of the Transporter

(2010) Ali El-Kasaby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study

(2010) Manju A Kurian et al.   LANCET NEUROLOGY

Behavioral consequences of dopamine deficiency in the Drosophila central nervous system

(2010) T. Riemensperger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pySolo: a complete suite for sleep analysis in Drosophila

(2009) G. F. Gilestro et al.   BIOINFORMATICS

Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia

(2009) Manju A. Kurian et al.   JOURNAL OF CLINICAL INVESTIGATION

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

(2009) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA