A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation

Cerebrospinal Fluid Proteins as Regulators of Beta-amyloid Aggregation and Toxicity

(2017) Kayla M. Pate et al.   ISRAEL JOURNAL OF CHEMISTRY

Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with β-amyloid

(2017) Tyler J. Perlenfein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma Cystatin C and High-Density Lipoprotein Are Important Biomarkers of Alzheimer’s Disease and Vascular Dementia: A Cross-Sectional Study

(2017) Rui Wang et al.   Frontiers in Aging Neuroscience

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation

(2017) Christine Xue et al.   Royal Society Open Science

Complexes of Amyloid-β and Cystatin C in the Human Central Nervous System

(2017) Weiqian Mi et al.   JOURNAL OF ALZHEIMERS DISEASE

Cystatin C Protects Neuronal Cells from Amyloid-β-induced Toxicity

(2017) Belen Tizon et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

(2017) Johan Sundelöf et al.   JOURNAL OF ALZHEIMERS DISEASE

Cystatin C in aging and in Alzheimer’s disease

(2016) Paul M. Mathews et al.   AGEING RESEARCH REVIEWS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

(2016) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease

(2016) Christine M Embury et al.   Journal of Neuroimmune Pharmacology

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Expression, purification, and characterization of human cystatin C monomers and oligomers

(2016) Tyler J. Perlenfein et al.   PROTEIN EXPRESSION AND PURIFICATION

Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells

(2016) Xia-Fei Wang et al.   PLoS One

Transthyretin as both a Sensor and a Scavenger of β-Amyloid Oligomers

(2013) Dennis T. Yang et al.   BIOCHEMISTRY

miR128 up-regulation correlates with impaired amyloid β(1-42) degradation in monocytes from patients with sporadic Alzheimer's disease

(2013) Roberto Tiribuzi et al.   NEUROBIOLOGY OF AGING

Glutamate treatment and preconditioning differently affect cathepsin B release and intracellular proteases in primary cultures of cerebellar granular cells

(2013) A. A. Yakovlev et al.   Neurochemical Journal

Alterations of CSF Cystatin C Levels and Their Correlations with CSF Αβ40 and Αβ42 Levels in Patients with Alzheimer's Disease, Dementia with Lewy Bodies and the Atrophic Form of General Paresis

(2013) Xiao-Mei Zhong et al.   PLoS One

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment

(2012) Valérie Laurent-Matha et al.   FASEB JOURNAL

Cathepsin B Degrades Amyloid-β in Mice Expressing Wild-type Human Amyloid Precursor Protein

(2012) Chao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Interaction of Thioflavin T with Amyloid Fibrils: Stoichiometry and Affinity of Dye Binding, Absorption Spectra of Bound Dye

(2011) Anna I. Sulatskaya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis

(2011) Rebecca Craig-Schapiro et al.   PLoS One

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Development of an immunoassay for the detection of cystatin C dimers

(2010) Heidi Hyytiä et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Model Discrimination and Mechanistic Interpretation of Kinetic Data in Protein Aggregation Studies

(2009) Joseph P. Bernacki et al.   BIOPHYSICAL JOURNAL

Binding Epitopes and Interaction Structure of the Neuroprotective Protease Inhibitor Cystatin C with β-Amyloid Revealed by Proteolytic Excision Mass Spectrometry and Molecular Docking Simulation

(2009) Paulina Juszczyk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein aggregation kinetics, mechanism, and curve-fitting: A review of the literature

(2008) Aimee M. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

(2008) Binggui Sun et al.   NEURON