Cerebrospinal Fluid Proteins as Regulators of Beta-amyloid Aggregation and Toxicity

Quantitative Analysis of Transthyretin, Tau and Amyloid-β in Patients with Dementia

(2017) Sara Friederike Gloeckner et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced Levels of Amyloid-β-Binding Proteins in Cerebrospinal Fluid from Alzheimer's Disease Patients

(2017) Sara F. Hansson et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry

(2016) Tarek Mohamed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Transthyretin variants with improved inhibition of β-amyloid aggregation

(2016) Parth Mangrolia et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Chemical Cross-Linking/Mass Spectrometry Maps the Amyloid β Peptide Binding Region on Both Apolipoprotein E Domains

(2015) Stéphanie Deroo et al.   ACS Chemical Biology

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

Structural, morphological, and functional diversity of amyloid oligomers

(2015) Leonid Breydo et al.   FEBS LETTERS

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease

(2015) Ibrahim González-Marrero et al.   Frontiers in Cellular Neuroscience

Transthyretin-Derived Peptides as β-Amyloid Inhibitors

(2014) Patricia Y. Cho et al.   ACS Chemical Neuroscience

The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

(2014) Kanchan Garai et al.   BIOCHEMISTRY

Amyloid-directed monoclonal antibodies for the treatment of Alzheimer’s disease: the point of no return?

(2014) Francesco Panza et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

α 1-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity

(2014) Maike Gold et al.   Journal of Neuroinflammation

Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

(2014) Saeed Sadigh-Eteghad et al.   MEDICAL PRINCIPLES AND PRACTICE

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

(2014) Leon M Tai et al.   Molecular Neurodegeneration

Combating neurodegenerative disease with chemical probes and model systems

(2014) Priyanka Narayan et al.   Nature Chemical Biology

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's disease

(2014) Frank Martin Schmidt et al.   NEUROSCIENCE LETTERS

Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X

(2013) Anja Hafner et al.   AGING CELL

Transthyretin as both a Sensor and a Scavenger of β-Amyloid Oligomers

(2013) Dennis T. Yang et al.   BIOCHEMISTRY

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

(2013) Roberta Cascella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

(2013) Amy R. Wyatt et al.   FEBS LETTERS

Mechanisms of Transthyretin Inhibition of  -Amyloid Aggregation In Vitro

(2013) X. Li et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics

(2012) A. Cocciolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model

(2012) J. Brouillette et al.   JOURNAL OF NEUROSCIENCE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

(2012) B. Mannini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of beta-amyloid-binding sites on transthyretin

(2012) J. Du et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Overlapping profiles of Abeta peptides in the Alzheimer's disease and pathological aging brains

(2012) Brenda D Moore et al.   Alzheimers Research & Therapy

Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques

(2011) J-Y Kim et al.   CELL DEATH AND DIFFERENTIATION

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease

(2011) Emilie Cerf et al.   FASEB JOURNAL

Neuronal Production of Transthyretin in Human and Murine Alzheimer's Disease: Is It Protective?

(2011) X. Li et al.   JOURNAL OF NEUROSCIENCE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Characterization of the Interaction of β-Amyloid with Transthyretin Monomers and Tetramers

(2010) Jiali Du et al.   BIOCHEMISTRY

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

(2010) Vladimir N. Uversky   CHEMICAL SOCIETY REVIEWS

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Possible Involvement of Transthyretin in Hippocampal β-Amyloid Burden and Learning Behaviors in a Mouse Model of Alzheimer’s Disease (TgCRND8)

(2010) Sihem Doggui et al.   Neurodegenerative Diseases

Aβ20–29 peptide blocking apoE/Aβ interaction reduces full-length Aβ42/40 fibril formation and cytotoxicity in vitro

(2010) Jian Hao et al.   NEUROPEPTIDES

A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution

(2010) Jitka Petrlova et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

In Silico Analysis of the Apolipoprotein E and the Amyloid β Peptide Interaction: Misfolding Induced by Frustration of the Salt Bridge Network

(2010) Jinghui Luo et al.   PLoS Computational Biology

Transthyretin as a potential CSF biomarker for Alzheimer’s disease and dementia with Lewy bodies: effects of treatment with cholinesterase inhibitors

(2009) K. Schultz et al.   EUROPEAN JOURNAL OF NEUROLOGY

An update on clinical proteomics in Alzheimer’s research

(2009) Minna A. Korolainen et al.   JOURNAL OF NEUROCHEMISTRY

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Asymmetric expression patterns of brain transthyretin in normal mice and a transgenic mouse model of Alzheimer's disease

(2009) K.-J. Tsai et al.   NEUROSCIENCE

Transthyretin binding to A-Beta peptide - Impact on A-Beta fibrillogenesis and toxicity

(2008) R. Costa et al.   FEBS LETTERS

α2-Macroglobulin and Haptoglobin Suppress Amyloid Formation by Interacting with Prefibrillar Protein Species

(2008) Justin J. Yerbury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Biological markers for axonal degeneration in CSF and blood of patients with the first event indicative for multiple sclerosis

(2008) Katharina Hein (née Maier) et al.   NEUROSCIENCE LETTERS

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

(2008) J. N. Buxbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA